Effects of Tea (Camellia sinensis) or its Bioactive Compounds l -Theanine or l -Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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· 2025
· Open Access
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· DOI: https://doi.org/10.1093/nutrit/nuaf054
Context The bioactive compounds found in tea from Camellia sinensis, namely theanine, caffeine, and polyphenols, can potentially improve short-term and long-term health outcomes. Objective The aim of this study was to assess the effects of tea, theanine alone, or theanine plus caffeine on cognition, mood, and sleep outcomes, using data from randomized controlled trials (RCTs) in healthy participants. Data sources The Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Embase, and Ovid Medline were searched up to and including August 2023. Data extraction Data relevant to the participants, interventions, comparisons, outcomes (ie, cognition, mood, and sleep), and study design were extracted. Data analysis Fifty RCTs were included in the review, of which 15 were eligible for at least 1 meta-analysis, most commonly performed by use of standardized mean differences (SMD), in random effects models. After intake of theanine plus caffeine, and of placebo, small-to-moderate differences were found between these interventions in the first hour (h1) and second hour (h2), that favoured theanine plus caffeine, with regard to cognition and mood outcomes such as choice reaction time (h1: SMD, −0.48; 95% CI, −1.01, 0.05), digit vigilance task accuracy (h2: SMD, 0.20; 95% CI, 0.02, 0.38), attention switching task accuracy (h2: SMD, 0.33; 95% CI, 0.13, 0.54), and overall mood (h2: SMD, 0.26; 95% CI,−0.10, 0.63). There was a small-to-moderate difference between the effects of theanine and placebo that favored theanine on choice reaction time (h1: SMD, −0.35; 95% CI,−0.61, −0.10). The CIs frequently highlighted the uncertainty surrounding the direction and magnitude of these differences. Conclusions This meta-analysis provides evidence that theanine plus caffeine, and theanine alone, could be beneficial for cognitive and mood outcomes. More research using tea beverages or tea-equivalent bioactive doses and research in free-living participants is needed. PROSPERO registration no CRD42022351601.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1093/nutrit/nuaf054
- OA Status
- green
- Cited By
- 2
- References
- 86
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410029930
Raw OpenAlex JSON
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https://openalex.org/W4410029930Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/nutrit/nuaf054Digital Object Identifier
- Title
-
Effects of Tea (Camellia sinensis) or its Bioactive Compounds
l -Theanine orl -Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsWork title - Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-05-02Full publication date if available
- Authors
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Edward R. Payne, Magaly Aceves‐Martins, Joy Dubost, Arno Greyling, Baukje de RoosList of authors in order
- Landing page
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https://doi.org/10.1093/nutrit/nuaf054Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/12422004Direct OA link when available
- Concepts
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Caffeine, Mood, Theanine, Placebo, Camellia sinensis, Medicine, Randomized controlled trial, Meta-analysis, Systematic review, Cognition, Internal medicine, Psychiatry, MEDLINE, Green tea, Food science, Biology, Alternative medicine, Botany, Biochemistry, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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86Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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