Effects of the supplementation of single and multi-strain probiotics, alone or in combination with other treatments, on asthma in children: A systematic review of the randomized, placebo-controlled clinical studies Article Swipe
Maria Daglia
,
Lorenzo Drago
,
Hammad Ullah
,
Alessandro Di Minno
,
Giulia Brindisi
,
Francesco Paolo Brunese
,
Giulio Dinardo
,
Alessandra Gori
,
Cristiana Indolfi
,
Matteo Naso
,
Enrico Tondina
,
Chiara Trincianti
,
Attilio Varricchio
,
Anna Maria Zicari
,
Giorgio Ciprandi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jff.2024.106599
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jff.2024.106599
Gut microbiota plays an important role in maintaining respiratory health while providing protection against respiratory illnesses. However, the clinical role of probiotic strains in prevention and treatment of early-onset asthma is still debated. The present study aims to systematically review the available literature on the efficacy of probiotic supplementation, either alone or in combination with other treatments, in managing children with asthma. An electronic search was conducted across multiple databases including PubMed, Web of Science, and EMBASE. The articles reported in English, regardless of year of publication, were reviewed by independent authors for inclusion assessment. Randomized controlled studies evaluating the efficacy of probiotics in children with asthma were included in the study. Of the 203 articles reviewed, 16 were selected and summarized to provide a consistent review, and of these, eight studies reported the anti-asthmatic effects of the treatment with single and multi-strain probiotics alone, seven reported the use of probiotic strains in combination with other treatments, and one was a follow-up study. While some of the studies reported are well conducted and with promising results, no cumulative significant impact was seen for probiotic supplementation on disease parameters of asthma in children. However, the available literature is not sufficient to draw any solid conclusion about the possible use of probiotics in children with asthma, and it is necessary to expand this literature by conducting more well-designed randomized clinical trials to assess the effects of probiotic strains in children with asthma or carrying a high-risk of asthma.
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Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jff.2024.106599
- OA Status
- gold
- Cited By
- 6
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405036898
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405036898Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jff.2024.106599Digital Object Identifier
- Title
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Effects of the supplementation of single and multi-strain probiotics, alone or in combination with other treatments, on asthma in children: A systematic review of the randomized, placebo-controlled clinical studiesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-01Full publication date if available
- Authors
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Maria Daglia, Lorenzo Drago, Hammad Ullah, Alessandro Di Minno, Giulia Brindisi, Francesco Paolo Brunese, Giulio Dinardo, Alessandra Gori, Cristiana Indolfi, Matteo Naso, Enrico Tondina, Chiara Trincianti, Attilio Varricchio, Anna Maria Zicari, Giorgio CiprandiList of authors in order
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https://doi.org/10.1016/j.jff.2024.106599Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.jff.2024.106599Direct OA link when available
- Concepts
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Randomized controlled trial, Asthma, Placebo, Medicine, Probiotic, Systematic review, Meta-analysis, Internal medicine, MEDLINE, Biology, Alternative medicine, Pathology, Biochemistry, Bacteria, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
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2025: 6Per-year citation counts (last 5 years)
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61Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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