Efficacy and safety of pregabalin in the management of low back pain: a comprehensive meta-analysis Article Swipe
Carlos Cordero‐García
,
Judith Sánchez‐Raya
,
Tamara L. Rodríguez‐Araya
,
María Dolores López‐Alarcón
,
Eva Trillo‐Calvo
,
Jerónimo Balsalobre‐Aznar
,
María Pérez‐Páramo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2025.1659531
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2025.1659531
Introduction Low back pain (LBP) is one of the most prevalent chronic pain conditions that affects nearly 50% of the population. Its complex pathophysiology may involve both nociceptive and neuropathic mechanisms and is often resistant to standard treatment. Pregabalin has emerged as a potential alternative owing to its mechanism of action, the inhibition of excitatory neurotransmitter release. This meta-analysis aimed to evaluate the efficacy and safety of pregabalin in managing LBP. Methods A systematic review of three major databases was conducted following the PRISMA guidelines. Studies were included if they were comparative studies of pregabalin with placebo or other pain medications, focusing on adult patients with LBP. Data were extracted on efficacy outcomes including pain reduction, anxiety, depression, quality of life, quality of sleep, disability, and adverse events. Statistical analysis was performed using Review Manager 5.4.1. Results A total of 18 studies ( n = 5,000) were included. Pregabalin demonstrated significant pain reduction at 4 weeks (Standardized Mean Difference (SMD) = −0.64, 95% Confidence Interval (CI) = −1.09 to −0.20), 6 weeks (SMD = −0.72, 95% CI = −1.15 to −0.29), and 8 weeks (SMD = −0.50, 95% CI = −0.71 to −0.29) compared to control group. Pregabalin also showed a significant greater improvement in anxiety (Mean Difference (MD) = −1.38, 95% CI = −1.74 to −1.02, p < 0.00001), depression (MD = −1.40, 95% CI = −1.71 to −1.08, p < 0.00001), quality of life (SMD = 0.22, 95% CI = 0.07 to 0.37, p = 0.003) and sleep quality (SMD = −0.61, 95% CI = −0.87 to −0.36, p < 0.00001). There were no significant differences regarding disability and adverse events. Conclusion Pregabalin in the treatment of neuropathic LBP demonstrated significant improvements in pain relief, associated symptoms of anxiety and depression, and enhancements in quality of life and sleep quality. In addition, it exhibits a favorable safety profile. Nevertheless, these findings should be interpreted with caution due to the limited quality of the evidence and the inadequate reporting of pain etiology in several included studies.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2025.1659531
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1659531/pdf
- OA Status
- gold
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4414067506
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4414067506Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fphar.2025.1659531Digital Object Identifier
- Title
-
Efficacy and safety of pregabalin in the management of low back pain: a comprehensive meta-analysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-08Full publication date if available
- Authors
-
Carlos Cordero‐García, Judith Sánchez‐Raya, Tamara L. Rodríguez‐Araya, María Dolores López‐Alarcón, Eva Trillo‐Calvo, Jerónimo Balsalobre‐Aznar, María Pérez‐PáramoList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2025.1659531Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1659531/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1659531/pdfDirect OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
62Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4414067506 |
|---|---|
| doi | https://doi.org/10.3389/fphar.2025.1659531 |
| ids.doi | https://doi.org/10.3389/fphar.2025.1659531 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40989845 |
| ids.openalex | https://openalex.org/W4414067506 |
| fwci | 0.0 |
| type | review |
| title | Efficacy and safety of pregabalin in the management of low back pain: a comprehensive meta-analysis |
| biblio.issue | |
| biblio.volume | 16 |
| biblio.last_page | 1659531 |
| biblio.first_page | 1659531 |
| topics[0].id | https://openalex.org/T10084 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2736 |
| topics[0].subfield.display_name | Pharmacology |
| topics[0].display_name | Musculoskeletal pain and rehabilitation |
| topics[1].id | https://openalex.org/T10238 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9970999956130981 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2734 |
| topics[1].subfield.display_name | Pathology and Forensic Medicine |
| topics[1].display_name | Spine and Intervertebral Disc Pathology |
| topics[2].id | https://openalex.org/T10189 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9958999752998352 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2746 |
| topics[2].subfield.display_name | Surgery |
| topics[2].display_name | Anesthesia and Pain Management |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| language | en |
| locations[0].id | doi:10.3389/fphar.2025.1659531 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S132108250 |
| locations[0].source.issn | 1663-9812 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1663-9812 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Pharmacology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1659531/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Pharmacology |
| locations[0].landing_page_url | https://doi.org/10.3389/fphar.2025.1659531 |
| locations[1].id | pmid:40989845 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in pharmacology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40989845 |
| locations[2].id | pmh:oai:doaj.org/article:7b39efe233c1418c8fb4b28d87185669 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Pharmacology, Vol 16 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/7b39efe233c1418c8fb4b28d87185669 |
| locations[3].id | pmh:oai:europepmc.org:11260765 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12451326 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5020374905 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-7359-3404 |
| authorships[0].author.display_name | Carlos Cordero‐García |
| authorships[0].countries | ES |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210129320 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Physical Medicine and Rehabilitation, Hospital Universitario Juan Ramón Jiménez, Huelva, Spain |
| authorships[0].institutions[0].id | https://openalex.org/I4210129320 |
| authorships[0].institutions[0].ror | https://ror.org/03fpqn433 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I158283456, https://openalex.org/I4210129320 |
| authorships[0].institutions[0].country_code | ES |
| authorships[0].institutions[0].display_name | Hospital Juan Ramón Jiménez |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Carlos Cordero‐García |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Physical Medicine and Rehabilitation, Hospital Universitario Juan Ramón Jiménez, Huelva, Spain |
| authorships[1].author.id | https://openalex.org/A5019900999 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-9356-7211 |
| authorships[1].author.display_name | Judith Sánchez‐Raya |
| authorships[1].countries | ES |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210127641 |
| authorships[1].affiliations[0].raw_affiliation_string | Physical Medicine and Rehabilitation Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain |
| authorships[1].institutions[0].id | https://openalex.org/I4210127641 |
| authorships[1].institutions[0].ror | https://ror.org/03ba28x55 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210127641 |
| authorships[1].institutions[0].country_code | ES |
| authorships[1].institutions[0].display_name | Vall d'Hebron Hospital Universitari |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Judith Sánchez‐Raya |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Physical Medicine and Rehabilitation Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain |
| authorships[2].author.id | https://openalex.org/A5119570903 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Tamara L. Rodríguez‐Araya |
| authorships[2].countries | ES |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210115097 |
| authorships[2].affiliations[0].raw_affiliation_string | Rheumatology Service, Hospital Clinic, Barcelona, Spain |
| authorships[2].institutions[0].id | https://openalex.org/I4210115097 |
| authorships[2].institutions[0].ror | https://ror.org/02a2kzf50 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210115097 |
| authorships[2].institutions[0].country_code | ES |
| authorships[2].institutions[0].display_name | Hospital Clínic de Barcelona |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Tamara L. Rodríguez‐Araya |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Rheumatology Service, Hospital Clinic, Barcelona, Spain |
| authorships[3].author.id | https://openalex.org/A5024276037 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | María Dolores López‐Alarcón |
| authorships[3].countries | ES |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210127649 |
| authorships[3].affiliations[0].raw_affiliation_string | Pain Unit, General University Hospital of Valencia, Valencia, Spain |
| authorships[3].institutions[0].id | https://openalex.org/I4210127649 |
| authorships[3].institutions[0].ror | https://ror.org/03sz8rb35 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210127649 |
| authorships[3].institutions[0].country_code | ES |
| authorships[3].institutions[0].display_name | Hospital General Universitario De Valencia |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | María Dolores López‐Alarcón |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Pain Unit, General University Hospital of Valencia, Valencia, Spain |
| authorships[4].author.id | https://openalex.org/A5030125387 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0816-3579 |
| authorships[4].author.display_name | Eva Trillo‐Calvo |
| authorships[4].countries | ES |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210136512 |
| authorships[4].affiliations[0].raw_affiliation_string | Primary Care, Aragon Institute for Health Research (IIS Aragón), Primary Care Center Campo de Belchite, Zaragoza, Spain |
| authorships[4].institutions[0].id | https://openalex.org/I4210136512 |
| authorships[4].institutions[0].ror | https://ror.org/03njn4610 |
| authorships[4].institutions[0].type | other |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210136512 |
| authorships[4].institutions[0].country_code | ES |
| authorships[4].institutions[0].display_name | Instituto de Investigación Sanitaria Aragón |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Eva Trillo‐Calvo |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Primary Care, Aragon Institute for Health Research (IIS Aragón), Primary Care Center Campo de Belchite, Zaragoza, Spain |
| authorships[5].author.id | https://openalex.org/A5119570904 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Jerónimo Balsalobre‐Aznar |
| authorships[5].countries | ES |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210106981 |
| authorships[5].affiliations[0].raw_affiliation_string | Rheumatology Service, Hospiten, Santa Cruz de Tenerife, Spain |
| authorships[5].institutions[0].id | https://openalex.org/I4210106981 |
| authorships[5].institutions[0].ror | https://ror.org/01csrpp22 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210106981 |
| authorships[5].institutions[0].country_code | ES |
| authorships[5].institutions[0].display_name | Hospiten Group |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jerónimo Balsalobre‐Aznar |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Rheumatology Service, Hospiten, Santa Cruz de Tenerife, Spain |
| authorships[6].author.id | https://openalex.org/A5053490407 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | María Pérez‐Páramo |
| authorships[6].affiliations[0].raw_affiliation_string | Medical Department, Viatris, Madrid, Spain |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Maria Pérez‐Páramo |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Medical Department, Viatris, Madrid, Spain |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1659531/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Efficacy and safety of pregabalin in the management of low back pain: a comprehensive meta-analysis |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10084 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2736 |
| primary_topic.subfield.display_name | Pharmacology |
| primary_topic.display_name | Musculoskeletal pain and rehabilitation |
| related_works | https://openalex.org/W2899084033, https://openalex.org/W2530540509, https://openalex.org/W2123191401, https://openalex.org/W4310040224, https://openalex.org/W2048488699, https://openalex.org/W2033371164, https://openalex.org/W1720984727, https://openalex.org/W4291291209, https://openalex.org/W3146803430, https://openalex.org/W2290108839 |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fphar.2025.1659531 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S132108250 |
| best_oa_location.source.issn | 1663-9812 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1663-9812 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Pharmacology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1659531/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Pharmacology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fphar.2025.1659531 |
| primary_location.id | doi:10.3389/fphar.2025.1659531 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S132108250 |
| primary_location.source.issn | 1663-9812 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1663-9812 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Pharmacology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1659531/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Pharmacology |
| primary_location.landing_page_url | https://doi.org/10.3389/fphar.2025.1659531 |
| publication_date | 2025-09-08 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4386727352, https://openalex.org/W4311756037, https://openalex.org/W2119752070, https://openalex.org/W1995468922, https://openalex.org/W2291450076, https://openalex.org/W4362548923, https://openalex.org/W2003437677, https://openalex.org/W4380085235, https://openalex.org/W4320480665, https://openalex.org/W3088760610, https://openalex.org/W2125208830, https://openalex.org/W37707754, https://openalex.org/W3118989194, https://openalex.org/W4308169934, https://openalex.org/W2271873799, https://openalex.org/W2903484394, https://openalex.org/W2337713014, https://openalex.org/W3128340089, https://openalex.org/W4377289287, https://openalex.org/W4317567454, https://openalex.org/W3207458175, https://openalex.org/W2064347247, https://openalex.org/W4304614205, https://openalex.org/W2567362164, https://openalex.org/W4225388781, https://openalex.org/W2031943790, https://openalex.org/W3131316834, https://openalex.org/W2313405450, https://openalex.org/W4391971416, https://openalex.org/W3134470325, https://openalex.org/W2122401423, https://openalex.org/W2805457007, https://openalex.org/W4384663703, https://openalex.org/W2600085695, https://openalex.org/W4285492376, https://openalex.org/W1982534727, https://openalex.org/W4408954647, https://openalex.org/W1985864941, https://openalex.org/W4361190107, https://openalex.org/W3118615836, https://openalex.org/W4394675900, https://openalex.org/W2888839272, https://openalex.org/W3130391353, https://openalex.org/W2995864680, https://openalex.org/W2147067563, https://openalex.org/W2896026881, https://openalex.org/W2053149411, https://openalex.org/W1974403730, https://openalex.org/W2117568115, https://openalex.org/W2150253727, https://openalex.org/W2746285343, https://openalex.org/W4280638456, https://openalex.org/W4290792214, https://openalex.org/W2017044005, https://openalex.org/W1852545608, https://openalex.org/W2080477042, https://openalex.org/W4221012474, https://openalex.org/W4403223091, https://openalex.org/W4353031842, https://openalex.org/W4304808243, https://openalex.org/W2118999229, https://openalex.org/W1665446506 |
| referenced_works_count | 62 |
| abstract_inverted_index.( | 142 |
| abstract_inverted_index.4 | 154 |
| abstract_inverted_index.6 | 170 |
| abstract_inverted_index.8 | 182 |
| abstract_inverted_index.= | 144, 160, 166, 173, 177, 185, 189, 209, 213, 222, 226, 237, 241, 246, 252, 256 |
| abstract_inverted_index.A | 72, 137 |
| abstract_inverted_index.a | 42, 200, 306 |
| abstract_inverted_index.n | 143 |
| abstract_inverted_index.p | 217, 230, 245, 260 |
| abstract_inverted_index.18 | 140 |
| abstract_inverted_index.CI | 176, 188, 212, 225, 240, 255 |
| abstract_inverted_index.In | 302 |
| abstract_inverted_index.as | 41 |
| abstract_inverted_index.at | 153 |
| abstract_inverted_index.be | 314 |
| abstract_inverted_index.if | 88 |
| abstract_inverted_index.in | 68, 204, 275, 284, 295, 333 |
| abstract_inverted_index.is | 5, 32 |
| abstract_inverted_index.it | 304 |
| abstract_inverted_index.no | 265 |
| abstract_inverted_index.of | 7, 18, 49, 53, 66, 75, 93, 119, 122, 139, 234, 278, 289, 297, 323, 330 |
| abstract_inverted_index.on | 102, 110 |
| abstract_inverted_index.or | 97 |
| abstract_inverted_index.to | 35, 46, 60, 168, 179, 191, 194, 215, 228, 243, 258, 319 |
| abstract_inverted_index.(MD | 221 |
| abstract_inverted_index.50% | 17 |
| abstract_inverted_index.95% | 162, 175, 187, 211, 224, 239, 254 |
| abstract_inverted_index.Its | 21 |
| abstract_inverted_index.LBP | 280 |
| abstract_inverted_index.Low | 1 |
| abstract_inverted_index.and | 28, 31, 64, 125, 181, 248, 270, 291, 293, 299, 326 |
| abstract_inverted_index.due | 318 |
| abstract_inverted_index.has | 39 |
| abstract_inverted_index.its | 47 |
| abstract_inverted_index.may | 24 |
| abstract_inverted_index.one | 6 |
| abstract_inverted_index.the | 8, 19, 51, 62, 82, 276, 320, 324, 327 |
| abstract_inverted_index.was | 79, 130 |
| abstract_inverted_index.(CI) | 165 |
| abstract_inverted_index.(MD) | 208 |
| abstract_inverted_index.(SMD | 172, 184, 236, 251 |
| abstract_inverted_index.0.07 | 242 |
| abstract_inverted_index.Data | 107 |
| abstract_inverted_index.LBP. | 70, 106 |
| abstract_inverted_index.Mean | 157 |
| abstract_inverted_index.This | 57 |
| abstract_inverted_index.also | 198 |
| abstract_inverted_index.back | 2 |
| abstract_inverted_index.both | 26 |
| abstract_inverted_index.life | 235, 298 |
| abstract_inverted_index.most | 9 |
| abstract_inverted_index.pain | 3, 12, 99, 114, 151, 285, 331 |
| abstract_inverted_index.that | 14 |
| abstract_inverted_index.they | 89 |
| abstract_inverted_index.were | 86, 90, 108, 146, 264 |
| abstract_inverted_index.with | 95, 105, 316 |
| abstract_inverted_index.(LBP) | 4 |
| abstract_inverted_index.(Mean | 206 |
| abstract_inverted_index.(SMD) | 159 |
| abstract_inverted_index.0.22, | 238 |
| abstract_inverted_index.0.37, | 244 |
| abstract_inverted_index.There | 263 |
| abstract_inverted_index.adult | 103 |
| abstract_inverted_index.aimed | 59 |
| abstract_inverted_index.life, | 120 |
| abstract_inverted_index.major | 77 |
| abstract_inverted_index.often | 33 |
| abstract_inverted_index.other | 98 |
| abstract_inverted_index.owing | 45 |
| abstract_inverted_index.sleep | 249, 300 |
| abstract_inverted_index.these | 311 |
| abstract_inverted_index.three | 76 |
| abstract_inverted_index.total | 138 |
| abstract_inverted_index.using | 132 |
| abstract_inverted_index.weeks | 155, 171, 183 |
| abstract_inverted_index.0.003) | 247 |
| abstract_inverted_index.5,000) | 145 |
| abstract_inverted_index.5.4.1. | 135 |
| abstract_inverted_index.PRISMA | 83 |
| abstract_inverted_index.Review | 133 |
| abstract_inverted_index.group. | 196 |
| abstract_inverted_index.nearly | 16 |
| abstract_inverted_index.review | 74 |
| abstract_inverted_index.safety | 65, 308 |
| abstract_inverted_index.should | 313 |
| abstract_inverted_index.showed | 199 |
| abstract_inverted_index.sleep, | 123 |
| abstract_inverted_index.Manager | 134 |
| abstract_inverted_index.Methods | 71 |
| abstract_inverted_index.Results | 136 |
| abstract_inverted_index.Studies | 85 |
| abstract_inverted_index.action, | 50 |
| abstract_inverted_index.adverse | 126, 271 |
| abstract_inverted_index.affects | 15 |
| abstract_inverted_index.anxiety | 205, 290 |
| abstract_inverted_index.caution | 317 |
| abstract_inverted_index.chronic | 11 |
| abstract_inverted_index.complex | 22 |
| abstract_inverted_index.control | 195 |
| abstract_inverted_index.emerged | 40 |
| abstract_inverted_index.events. | 127, 272 |
| abstract_inverted_index.greater | 202 |
| abstract_inverted_index.involve | 25 |
| abstract_inverted_index.limited | 321 |
| abstract_inverted_index.placebo | 96 |
| abstract_inverted_index.quality | 118, 121, 233, 250, 296, 322 |
| abstract_inverted_index.relief, | 286 |
| abstract_inverted_index.several | 334 |
| abstract_inverted_index.studies | 92, 141 |
| abstract_inverted_index.−0.71 | 190 |
| abstract_inverted_index.−0.87 | 257 |
| abstract_inverted_index.−1.09 | 167 |
| abstract_inverted_index.−1.15 | 178 |
| abstract_inverted_index.−1.71 | 227 |
| abstract_inverted_index.−1.74 | 214 |
| abstract_inverted_index.&lt; | 218, 231, 261 |
| abstract_inverted_index.Interval | 164 |
| abstract_inverted_index.analysis | 129 |
| abstract_inverted_index.anxiety, | 116 |
| abstract_inverted_index.compared | 193 |
| abstract_inverted_index.efficacy | 63, 111 |
| abstract_inverted_index.etiology | 332 |
| abstract_inverted_index.evaluate | 61 |
| abstract_inverted_index.evidence | 325 |
| abstract_inverted_index.exhibits | 305 |
| abstract_inverted_index.findings | 312 |
| abstract_inverted_index.focusing | 101 |
| abstract_inverted_index.included | 87, 335 |
| abstract_inverted_index.managing | 69 |
| abstract_inverted_index.outcomes | 112 |
| abstract_inverted_index.patients | 104 |
| abstract_inverted_index.profile. | 309 |
| abstract_inverted_index.quality. | 301 |
| abstract_inverted_index.release. | 56 |
| abstract_inverted_index.standard | 36 |
| abstract_inverted_index.studies. | 336 |
| abstract_inverted_index.symptoms | 288 |
| abstract_inverted_index.−0.29) | 192 |
| abstract_inverted_index.−0.36, | 259 |
| abstract_inverted_index.−0.50, | 186 |
| abstract_inverted_index.−0.61, | 253 |
| abstract_inverted_index.−0.64, | 161 |
| abstract_inverted_index.−0.72, | 174 |
| abstract_inverted_index.−1.02, | 216 |
| abstract_inverted_index.−1.08, | 229 |
| abstract_inverted_index.−1.38, | 210 |
| abstract_inverted_index.−1.40, | 223 |
| abstract_inverted_index.0.00001), | 219, 232 |
| abstract_inverted_index.0.00001). | 262 |
| abstract_inverted_index.addition, | 303 |
| abstract_inverted_index.conducted | 80 |
| abstract_inverted_index.databases | 78 |
| abstract_inverted_index.extracted | 109 |
| abstract_inverted_index.favorable | 307 |
| abstract_inverted_index.following | 81 |
| abstract_inverted_index.included. | 147 |
| abstract_inverted_index.including | 113 |
| abstract_inverted_index.mechanism | 48 |
| abstract_inverted_index.performed | 131 |
| abstract_inverted_index.potential | 43 |
| abstract_inverted_index.prevalent | 10 |
| abstract_inverted_index.reduction | 152 |
| abstract_inverted_index.regarding | 268 |
| abstract_inverted_index.reporting | 329 |
| abstract_inverted_index.resistant | 34 |
| abstract_inverted_index.treatment | 277 |
| abstract_inverted_index.−0.20), | 169 |
| abstract_inverted_index.−0.29), | 180 |
| abstract_inverted_index.Conclusion | 273 |
| abstract_inverted_index.Confidence | 163 |
| abstract_inverted_index.Difference | 158, 207 |
| abstract_inverted_index.Pregabalin | 38, 148, 197, 274 |
| abstract_inverted_index.associated | 287 |
| abstract_inverted_index.conditions | 13 |
| abstract_inverted_index.depression | 220 |
| abstract_inverted_index.disability | 269 |
| abstract_inverted_index.excitatory | 54 |
| abstract_inverted_index.inadequate | 328 |
| abstract_inverted_index.inhibition | 52 |
| abstract_inverted_index.mechanisms | 30 |
| abstract_inverted_index.pregabalin | 67, 94 |
| abstract_inverted_index.reduction, | 115 |
| abstract_inverted_index.systematic | 73 |
| abstract_inverted_index.treatment. | 37 |
| abstract_inverted_index.Statistical | 128 |
| abstract_inverted_index.alternative | 44 |
| abstract_inverted_index.comparative | 91 |
| abstract_inverted_index.depression, | 117, 292 |
| abstract_inverted_index.differences | 267 |
| abstract_inverted_index.disability, | 124 |
| abstract_inverted_index.guidelines. | 84 |
| abstract_inverted_index.improvement | 203 |
| abstract_inverted_index.interpreted | 315 |
| abstract_inverted_index.neuropathic | 29, 279 |
| abstract_inverted_index.nociceptive | 27 |
| abstract_inverted_index.population. | 20 |
| abstract_inverted_index.significant | 150, 201, 266, 282 |
| abstract_inverted_index.Introduction | 0 |
| abstract_inverted_index.demonstrated | 149, 281 |
| abstract_inverted_index.enhancements | 294 |
| abstract_inverted_index.improvements | 283 |
| abstract_inverted_index.medications, | 100 |
| abstract_inverted_index.(Standardized | 156 |
| abstract_inverted_index.Nevertheless, | 310 |
| abstract_inverted_index.meta-analysis | 58 |
| abstract_inverted_index.pathophysiology | 23 |
| abstract_inverted_index.neurotransmitter | 55 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5020374905 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I4210129320 |
| citation_normalized_percentile.value | 0.43600574 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |