Efficacy and safety of the metformin-mazindol anorectic combination in rat Article Swipe
FEDERICO A. ARGÜELLES-TELLO
,
José Eduardo Roa‐Coria
,
Ángel Zúñiga‐Romero
,
Juan Carlos Huerta-Cruz
,
Geovanna Nalley Quiñonez-Bastidas
,
Francisco Javier Flores‐Murrieta
,
Héctor Isaac Rocha‐González
,
Gerardo Reyes‐García
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.2478/acph-2021-0019
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.2478/acph-2021-0019
The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered per os , individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 ( ED 40t ) did not differ from the experimental effective dose 40 ( ED 40e ) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s t -test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED 40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2478/acph-2021-0019
- OA Status
- gold
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3097420907
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3097420907Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2478/acph-2021-0019Digital Object Identifier
- Title
-
Efficacy and safety of the metformin-mazindol anorectic combination in ratWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-11-04Full publication date if available
- Authors
-
FEDERICO A. ARGÜELLES-TELLO, José Eduardo Roa‐Coria, Ángel Zúñiga‐Romero, Juan Carlos Huerta-Cruz, Geovanna Nalley Quiñonez-Bastidas, Francisco Javier Flores‐Murrieta, Héctor Isaac Rocha‐González, Gerardo Reyes‐GarcíaList of authors in order
- Landing page
-
https://doi.org/10.2478/acph-2021-0019Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.2478/acph-2021-0019Direct OA link when available
- Concepts
-
Mazindol, Anorectic, Metformin, Medicine, Pharmacology, Endocrinology, Internal medicine, Diabetes mellitus, Body weight, DopamineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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