Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial Article Swipe
Somayyeh Khalilzadeh
,
Tahereh Eftkhar
,
Laila Shirbeigi
,
Malihe Tabarrai
,
Tayebeh Toliyat
,
Shamim Fayazmanesh
,
Zeinab Ghasemi
,
Safar Shamohammadi
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1080/13880209.2020.1784236
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1080/13880209.2020.1784236
Context: In Persian medicine, topical ingredients such as Rosa damascena Mill. (Rosaceae), are usually recommended for the treatment of uterine diseases. Scientific evaluation of these historical documents can be valuable for finding new potential use in conventional medicine.Objective: This clinical trial was performed to determine whether the use of the 'ward' vaginal tablet, which contains Rosa damascena, Punica granatum L. (Punicaceae), Querqus infectoria Oliv. (Fagaceae), Myrtus communis L. (Myrtaceae) and Nardostachys jatamansi (D.Don) DC. (Caprifoliaceae) could alleviate the symptoms of vulvovaginal candidiasis.Materials and methods: A parallel double-blinded placebo-controlled study was done. Eighteen to fifty-year-old women with vulvovaginal candidiasis were divided into the 'ward' and placebo groups, 46 individuals in each group. The 'ward' group received the 'ward' vaginal tablet containing 200 mg of dried extract. Placebo group received a placebo (composed of corn starch and lactose). One tablet was applied through the vagina for 7 consecutive nights.Results: Two weeks after medication administration, the vaginal discharge sample of patients was re-cultured; 29 patients (63.045%) in the 'ward' group and 6 (13.04%) patients in the placebo group had negative culture (p < 0.001). All clinical symptoms including itching, irritation, and vaginal discharge were significantly reduced in the 'ward' group compared with the placebo group following the intervention and the follow up (p < 0.05).Discussion and conclusions: The findings suggest the 'ward' vaginal tablet could ameliorate vulvovaginal candidiasis. Future larger studies are recommended due to compare the therapeutic effect of the 'ward' vaginal tablet with common treatments.
Related Topics
Concepts
Placebo
Medicine
Rosa × damascena
Context (archaeology)
Myrtus communis
Randomized controlled trial
Intravaginal administration
Traditional medicine
Clinical trial
Vulvovaginal Candidiasis
Vagina
Internal medicine
Surgery
Dermatology
Alternative medicine
Chemistry
Pathology
Chromatography
Biology
Paleontology
Antifungal
Essential oil
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/13880209.2020.1784236
- https://www.tandfonline.com/doi/pdf/10.1080/13880209.2020.1784236?needAccess=true
- OA Status
- gold
- Cited By
- 7
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3040480149
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3040480149Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/13880209.2020.1784236Digital Object Identifier
- Title
-
Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-01Full publication date if available
- Authors
-
Somayyeh Khalilzadeh, Tahereh Eftkhar, Laila Shirbeigi, Malihe Tabarrai, Tayebeh Toliyat, Shamim Fayazmanesh, Zeinab Ghasemi, Safar ShamohammadiList of authors in order
- Landing page
-
https://doi.org/10.1080/13880209.2020.1784236Publisher landing page
- PDF URL
-
https://www.tandfonline.com/doi/pdf/10.1080/13880209.2020.1784236?needAccess=trueDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.tandfonline.com/doi/pdf/10.1080/13880209.2020.1784236?needAccess=trueDirect OA link when available
- Concepts
-
Placebo, Medicine, Rosa × damascena, Context (archaeology), Myrtus communis, Randomized controlled trial, Intravaginal administration, Traditional medicine, Clinical trial, Vulvovaginal Candidiasis, Vagina, Internal medicine, Surgery, Dermatology, Alternative medicine, Chemistry, Pathology, Chromatography, Biology, Paleontology, Antifungal, Essential oilTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2023: 1, 2022: 2Per-year citation counts (last 5 years)
- References (count)
-
39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2124826696, https://openalex.org/W2298437203, https://openalex.org/W2538028846, https://openalex.org/W1965626289, https://openalex.org/W2086849330, https://openalex.org/W1985013686, https://openalex.org/W2035051129, https://openalex.org/W2513925126, https://openalex.org/W2066897427, https://openalex.org/W2130064611, https://openalex.org/W2211921708, https://openalex.org/W2065005310, https://openalex.org/W2051829043, https://openalex.org/W1988617323, https://openalex.org/W2944189475, https://openalex.org/W1672254856, https://openalex.org/W2786174090, https://openalex.org/W2007818273, https://openalex.org/W2899038225, https://openalex.org/W2135769723, https://openalex.org/W1977781758, https://openalex.org/W2136950447, https://openalex.org/W2028991834, https://openalex.org/W2767472982, https://openalex.org/W2150428940, https://openalex.org/W1517994472, https://openalex.org/W2155772392, https://openalex.org/W2172046963, https://openalex.org/W4237188424, https://openalex.org/W2072237424, https://openalex.org/W1445196619, https://openalex.org/W1879555632, https://openalex.org/W2018380620, https://openalex.org/W2104292810, https://openalex.org/W107056468, https://openalex.org/W2301673943, https://openalex.org/W2048270565, https://openalex.org/W4210949879, https://openalex.org/W2600013358 |
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