Efficacy of Intravenous Immunoglobulin Replacement Therapy in Patients with Predominantly Antibody Deficiency Article Swipe
Shereen M. Reda
,
Mourad Alfy Ramzy
,
Hebat Allah MM Waheed El-din
,
Nesrine Radwan
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/qjmed/hcab113.028
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/qjmed/hcab113.028
Background Intravenous immunoglobulin G (IVIG) has been used as an antibody replacement therapy in primary immunodeficiency (PID) for more than 50 years. Most routinely, IVIG is used in patients with predominantly antibody deficiency such as: X-linked Agammaglobulinemia, common variable immunodeficiency and combined immunodeficiency such as: severe combined immunodeficiency. Aim To evaluate the efficacy and safety of regular IVIG therapy among patients with predominantly antibody deficiency in terms of frequency of infection and adverse effects. Methods Thirty patients diagnosed with predominantly antibody deficiency were recruited from the Pediatric Allergy and Immunology Unit, Children’s Hospital, Ain Shams University. These patients were followed up for one year in order to evaluate the frequency of infection and and adverse reactions of regular monthly IVIG therapy. The adequacy of IVIG dose was evaluated by the trough level of serum immunoglobulin G (IgG). Results Of the 30 patients, 21 (70%) were males and 9 (30%) were females. They had a median age of 87 months (range:15-294). Their median age at presentation and at diagnosis were 36 months (range :3-168) and 87 months (range:15-204) respectively. The mean ± SD of serum IgG before commencement of IVIG and after were 265.10 ± 108.39mg/dl and 572.04 ± 186.72 respectively. The rate of major infection dropped after starting replacement therapy with a median of 2 (1-2) before and 0 (0-1) after treatment. In spite of the reduction in the rate of pneumonia occurrence in patients with IgG trough level >500 mg/dl, it had no statistical significance. This could be attributable to small sample size. One patient developed anaphylaxis and was shifted to another brand. Conclusion IVIG is a safe and effective drug for patients with predominantly antibody deficiency. Compliance, adherence to therapy and appropriate dosage is needed to achieve better infection control.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/qjmed/hcab113.028
- https://academic.oup.com/qjmed/article-pdf/114/Supplement_1/hcab113.028/40497141/hcab113.028.pdf
- OA Status
- bronze
- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3201786392
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3201786392Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/qjmed/hcab113.028Digital Object Identifier
- Title
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Efficacy of Intravenous Immunoglobulin Replacement Therapy in Patients with Predominantly Antibody DeficiencyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-10-01Full publication date if available
- Authors
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Shereen M. Reda, Mourad Alfy Ramzy, Hebat Allah MM Waheed El-din, Nesrine RadwanList of authors in order
- Landing page
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https://doi.org/10.1093/qjmed/hcab113.028Publisher landing page
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https://academic.oup.com/qjmed/article-pdf/114/Supplement_1/hcab113.028/40497141/hcab113.028.pdfDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/qjmed/article-pdf/114/Supplement_1/hcab113.028/40497141/hcab113.028.pdfDirect OA link when available
- Concepts
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Medicine, Primary immunodeficiency, Common variable immunodeficiency, Adverse effect, Antibody, Trough level, Internal medicine, Intravenous Immunoglobulin Therapy, Pediatrics, Immunodeficiency, Gastroenterology, Immunology, Disease, Immune system, Transplantation, TacrolimusTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2021: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| primary_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
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