Efficacy of intravitreal conbercept combined with panretinal photocoagulation for severe nonproliferative diabetic retinopathy without macular edema Article Swipe
Ning Zhao
,
Jian‐Long Guan
,
Na Cai
,
Ningning Liu
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.18240/ijo.2022.04.15
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.18240/ijo.2022.04.15
AIM: To assess efficacy of intravitreal conbercept (IVC) injection in combination with panretinal photocoagulation (PRP) vs PRP alone in patients with severe nonproliferative diabetic retinopathy (SNPDR) without macular edema (ME). METHODS: Forty-eight patients with SNPDR without ME (56 eyes) were divided into the PRP group and IVC+PRP group (the pulse group) in this retrospective clinical study. Conbercept was intravitreally administered to patients in the pulse group 1wk before treatment with PRP and followed up for 1, 3, and 6mo. The best-corrected visual acuity (BCVA, logMAR), center foveal thickness (CFT), visual acuity (VA) improvement, and adverse reactions were compared between groups. RESULTS: In the PRP group, the BCVA reduced at 1 and 3mo before improving at 6mo. In the pulse group, baseline BCVA decreased continuously at 1mo, increased at 3 and 6mo. BCVA in the pulse group was better than that in the PRP group at 1, 3, and 6mo. There was an increase in CFT in the PRP group during follow-up compared with baseline. In the pulse group, CFT was increased at 1mo relative to baseline, steadily decreased to the baseline level at 3 and 6mo. There was a more significant reduction in CFT in the pulse group during follow-up compared with the PRP group. The effective rates of VA in the PRP and the pulse groups were 81.48% and 100%, respectively. CONCLUSION: As PRP pretreatment, a single dose of IVC administration has beneficial effects for preventing PRP-induced foveal thickening and increasing VA in patients with SNPDR without ME.
Related Topics
Concepts
Medicine
Panretinal photocoagulation
Visual acuity
Diabetic retinopathy
Ophthalmology
Macular edema
Diabetes mellitus
Endocrinology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18240/ijo.2022.04.15
- OA Status
- gold
- Cited By
- 2
- References
- 31
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4220824035Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18240/ijo.2022.04.15Digital Object Identifier
- Title
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Efficacy of intravitreal conbercept combined with panretinal photocoagulation for severe nonproliferative diabetic retinopathy without macular edemaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-30Full publication date if available
- Authors
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Ning Zhao, Jian‐Long Guan, Na Cai, Ningning LiuList of authors in order
- Landing page
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https://doi.org/10.18240/ijo.2022.04.15Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.18240/ijo.2022.04.15Direct OA link when available
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Medicine, Panretinal photocoagulation, Visual acuity, Diabetic retinopathy, Ophthalmology, Macular edema, Diabetes mellitus, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 1, 2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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