Efficacy of Jatropha Sap (Jatropha curcas L.) Cream on Epithelialization Phase of Cutaneous Wound Healing in Mice Using Masson Trichome Staining Article Swipe
M. Nur Salim
,
Ummu Balqis
,
Rahma Erlis
,
Dian Masyitha
,
Erdiansyah Rahmi
,
Abdul Harris
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.2991/absr.k.210420.014
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.2991/absr.k.210420.014
This study aims to determine the efficacy of 10% Jatropha curcas Linn.cream on the epithelialization phase of cutaneous wound healing in mice (Mus musculus) using Masson Trichrome staining.This study used nine male mice, aged 2-3 months old with 2 cm incision was made on the back.The mice were divided into three treatment groups with three replications.Treatment I was applied with cream base (P1), treatment II was applied with 10% Jatropha's sap cream (P2), and treatment III was applied with sulfadiazine (P3).The wound was treated twice a day for seven days.The observed parameters were collagen density, fibroblast formation and angiogenesis in each treatment group.The data were analyzed by ANOVA followed by Duncan test if there were differences between the treatment groups.The results showed that collagen density in P1, P2, and P3 were 1.58 ± 0.00, 2.04 ± 0.14, and 1.95 ± 0.14, respectively, indicating a very significant difference (p <0.01).Fibroblasts formation did not differ (p> 0.05) among treatments with the values in P1, P2, and P3 were 2.04 ± 0.14, 1.56 ± 0.32, 1.95 ± 0.14, respectively.Angiogenesis in P1, P2, and P3 were 1.46 ± 0.21, 1.87 ± 0.00, 1.46 ± 0.21, respectively, which had a significant effect (p <0.05).It is concluded that application of 10% Jatropha cream for seven days is effective in increasing collagen density and angiogenesis that accelerate the cutaneous wound healing in mice.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2991/absr.k.210420.014
- https://www.atlantis-press.com/article/125955632.pdf
- OA Status
- hybrid
- References
- 7
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3157954242
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3157954242Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2991/absr.k.210420.014Digital Object Identifier
- Title
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Efficacy of Jatropha Sap (Jatropha curcas L.) Cream on Epithelialization Phase of Cutaneous Wound Healing in Mice Using Masson Trichome StainingWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-01-01Full publication date if available
- Authors
-
M. Nur Salim, Ummu Balqis, Rahma Erlis, Dian Masyitha, Erdiansyah Rahmi, Abdul HarrisList of authors in order
- Landing page
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https://doi.org/10.2991/absr.k.210420.014Publisher landing page
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https://www.atlantis-press.com/article/125955632.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.atlantis-press.com/article/125955632.pdfDirect OA link when available
- Concepts
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Jatropha curcas, Trichome, Wound healing, Jatropha, Staining, Botany, Chemistry, Traditional medicine, Horticulture, Biology, Medicine, Pathology, Surgery, Biochemistry, Biodiesel, CatalysisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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7Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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