Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study Article Swipe
Brigitte Dréno
,
Jean‐Michel Nguyen
,
E. Hainaut
,
L. Machet
,
M.‐T. Leccia
,
N. Bénéton
,
Jean-Paul Claudel
,
P. Célérier
,
M. Le Moigne
,
S. Le Naour
,
Florence Vrignaud
,
Alexandra Poinas
,
Cécile Dert
,
Aurélie Boisrobert
,
Laurent Flet
,
Simon Korner
,
Amir Khammari
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2340/actadv.v104.26002
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2340/actadv.v104.26002
Acne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel study assessed the efficacy of spironolactone compared with doxycycline in adult female acne. A total of 133 women with moderate acne were randomized to receive treatment with: (i) doxycycline and benzoyl peroxide for 3 months followed by a 3-month treatment with its placebo and benzoyl peroxide, or (ii) spironolactone and benzoyl peroxide for 6 months. Successfully treated patients continued with benzoyl peroxide or spironolactone alone for a further 6 months. Primary endpoints were treatment success at month 4 and month 6 with the AFAST score. At all visits, the ECLA score, lesion counts, local and systemic safety and quality of life were assessed. Spironolactone performed better at month 4 and showed a statistically significant better treatment success after 6 months than doxycycline (p = 0.007). Spironolactone was 1.37-times and 2.87-times more successful compared with doxycycline at respective time-points. AFAST and ECLA scores, as well as lesion counts always improved more with spironolactone. Patients’ quality of life was better with spironolactone at month 4 and month 6. Spironolactone was very well tolerated. This is the first study to show that, in female adults with moderate acne, treatment with spironolactone is significantly more successful than doxycycline and very well tolerated.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2340/actadv.v104.26002
- https://medicaljournalssweden.se/actadv/article/download/26002/45401
- OA Status
- gold
- Cited By
- 18
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391995723
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391995723Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2340/actadv.v104.26002Digital Object Identifier
- Title
-
Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-21Full publication date if available
- Authors
-
Brigitte Dréno, Jean‐Michel Nguyen, E. Hainaut, L. Machet, M.‐T. Leccia, N. Bénéton, Jean-Paul Claudel, P. Célérier, M. Le Moigne, S. Le Naour, Florence Vrignaud, Alexandra Poinas, Cécile Dert, Aurélie Boisrobert, Laurent Flet, Simon Korner, Amir KhammariList of authors in order
- Landing page
-
https://doi.org/10.2340/actadv.v104.26002Publisher landing page
- PDF URL
-
https://medicaljournalssweden.se/actadv/article/download/26002/45401Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://medicaljournalssweden.se/actadv/article/download/26002/45401Direct OA link when available
- Concepts
-
Spironolactone, Acne, Doxycycline, Medicine, Benzoyl peroxide, Antiandrogen, Internal medicine, Randomized controlled trial, Placebo, Gastroenterology, Urology, Dermatology, Antibiotics, Androgen, Hormone, Aldosterone, Pathology, Chemistry, Alternative medicine, Organic chemistry, Polymer, Biochemistry, PolymerizationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 16, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Doxycycline | 9 |
| abstract_inverted_index.Patients’ | 192 |
| abstract_inverted_index.controlled, | 34 |
| abstract_inverted_index.doxycycline | 48, 68, 161, 174, 233 |
| abstract_inverted_index.prospective | 37 |
| abstract_inverted_index.randomized, | 35 |
| abstract_inverted_index.significant | 153 |
| abstract_inverted_index.Successfully | 95 |
| abstract_inverted_index.double-blind | 36 |
| abstract_inverted_index.multicentre, | 33 |
| abstract_inverted_index.time-points. | 177 |
| abstract_inverted_index.significantly | 229 |
| abstract_inverted_index.statistically | 152 |
| abstract_inverted_index.Spironolactone | 16, 143, 165, 206 |
| abstract_inverted_index.spironolactone | 45, 88, 103, 199, 227 |
| abstract_inverted_index.spironolactone. | 191 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 17 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.699999988079071 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.99028218 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |