Efficacy of Whole-Brain Radiotherapy Plus Simultaneous Integrated Boost (SIB-WBRT) for Lung Cancer Brain Metastases Article Swipe
Qian Bi
,
Jing Shen
,
Pengyu Li
,
Yuhao Zeng
,
Xin Lian
,
Fuquan Zhang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7150/jca.95804
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7150/jca.95804
Objective: To investigate the outcomes of SIB-WBRT in patients with brain metastases and analyze the impact of some factors on prognosis. Materials and Methods: This single-arm retrospective study analyzed patients with brain metastases who were treated with SIB-WBRT at Peking Union Medical College Hospital from September 2015 to December 2021. The primary endpoint was intracranial progression free survival (iPFS). Secondary endpoints included overall survival (OS), intracranial new foci, and tumor control. The Kaplan-Meier method was then used to depict and estimate iPFS, OS, intracranial neoplasia, and tumor control. Finally, the Cox model was used to analyze the association between some relevant factors and outcomes. Results: A total of 107 patients were included and the median iPFS in these patients treated with SIB-WBRT was 13.4 (95% CI: 4.2-22.6) months, with 68.0% (95% CI: 57.4%-78.6%) and 50.8% (95% CI: 38.3%-63.3%) iPFS at 6- and 12-months. The median local control was 37.6 (95% CI: 28.3-46.8) months, with local control rates of 84.3% (95% CI: 80.6%-88.0%) and 73.3% (95% CI: 68.2%-78.4%) at 6- and 12-months. The median time to appearance of new intracranial foci was 17.4 (95% CI: 14.1-20.8) months, and the 6- and 12-month control rates were 74.5% (95% CI: 64.5%-84.5%) and 61.5% (95% CI: 49.0%-74.0%). The number of brain metastases in patients before treatment was significantly associated with iPFS (HR=0.4, 95% CI: 0.2-0.973, P=0.043). Conclusions: The iPFS, local control, and intracranial new foci of patients with brain metastases after treatment with SIB-WBRT were acceptable. In addition, the number of brain metastases in patients before treatment may be associated with iPFS.
Related Topics
Concepts
Medicine
Clinical endpoint
Lung cancer
Internal medicine
Whole brain radiotherapy
Radiation therapy
Overall survival
Surgery
Brain metastasis
Proportional hazards model
Cancer
Oncology
Randomized controlled trial
Metastasis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7150/jca.95804
- https://www.jcancer.org/v15p4636.pdf
- OA Status
- gold
- Cited By
- 8
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400254736
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400254736Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7150/jca.95804Digital Object Identifier
- Title
-
Efficacy of Whole-Brain Radiotherapy Plus Simultaneous Integrated Boost (SIB-WBRT) for Lung Cancer Brain MetastasesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-01Full publication date if available
- Authors
-
Qian Bi, Jing Shen, Pengyu Li, Yuhao Zeng, Xin Lian, Fuquan ZhangList of authors in order
- Landing page
-
https://doi.org/10.7150/jca.95804Publisher landing page
- PDF URL
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https://www.jcancer.org/v15p4636.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.jcancer.org/v15p4636.pdfDirect OA link when available
- Concepts
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Medicine, Clinical endpoint, Lung cancer, Internal medicine, Whole brain radiotherapy, Radiation therapy, Overall survival, Surgery, Brain metastasis, Proportional hazards model, Cancer, Oncology, Randomized controlled trial, MetastasisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 2Per-year citation counts (last 5 years)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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