Efficacy, safety, and patient satisfaction with oral semaglutide: first single-centre clinical experience Article Swipe
Miodrag Janić
,
Marija Jovanović
,
Andrej Janež
,
Mojca Lunder
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/03000605231211402
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/03000605231211402
Objective To explore the effects of oral semaglutide on glycaemic parameters, body weight, and satisfaction in the first recipient patients with type 2 diabetes mellitus in Slovenia, in a real-world clinical practice setting. Methods The first consecutive adult patients with type 2 diabetes who were eligible for oral semaglutide treatment were included in this prospective, open-label interventional study. Patients received increasing doses of oral semaglutide and were evaluated at inclusion, at 1 month, then 3–5 months after starting treatment. Fasting blood glucose, glycosylated haemoglobin (HbA1c), body weight, patient satisfaction with oral semaglutide treatment (using the validated Treatment Satisfaction Questionnaire for Medication), and adverse effects, were analysed. Statistical analyses were performed using one-way analysis of variance, and, when significant interactions were found, Bonferroni post-hoc test. A P-value <0.05 was considered statistically significant. Results Twenty patients (11 male: 9 female; mean age, 59.9 ± 1.5 years; mean diabetes duration, 8.5 ± 1.4 years) were included. Oral semaglutide (7 and 14 mg) significantly decreased HbA1c (from 9.4 ± 0.3% to 8.2 ± 0.2% and 7.8 ± 0.2%, respectively) and fasting plasma glucose (from 11.2 ± 0.5 mmol/L to 9.2 ± 0.7 mmol/L and 8.9 ± 0.4 mmol/L, respectively). Oral semaglutide (14 mg) significantly decreased body weight (from 100.9 ± 2.7 kg to 92.7 ± 2.4 kg). Patients reported that treatment was easy to use and expressed high global satisfaction. Mild and transient, mostly gastrointestinal, adverse effects were reported in 10 patients. Conclusions Oral semaglutide, the first oral glucagon-like peptide 1 receptor agonist, was effective and safe, and associated with high patient satisfaction, in its first recipients in Slovenia. The results are important for daily clinical practice involving patients with type 2 diabetes, however, due to the small study population, lack of placebo control, and short exposure to oral semaglutide, the effectiveness of oral semaglutide in clinical practice requires further investigation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/03000605231211402
- OA Status
- gold
- Cited By
- 4
- References
- 25
- Related Works
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- OpenAlex ID
- https://openalex.org/W4388870006
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388870006Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/03000605231211402Digital Object Identifier
- Title
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Efficacy, safety, and patient satisfaction with oral semaglutide: first single-centre clinical experienceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-11-01Full publication date if available
- Authors
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Miodrag Janić, Marija Jovanović, Andrej Janež, Mojca LunderList of authors in order
- Landing page
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https://doi.org/10.1177/03000605231211402Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1177/03000605231211402Direct OA link when available
- Concepts
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Semaglutide, Medicine, Adverse effect, Patient satisfaction, Internal medicine, Type 2 diabetes, Body weight, Diabetes mellitus, Analysis of variance, Prospective cohort study, Clinical trial, Statistical significance, Gastroenterology, Surgery, Endocrinology, LiraglutideTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 1, 2024: 3Per-year citation counts (last 5 years)
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25Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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