Egyptian cobra (Naja haje haje) venom phospholipase A2: a promising antiviral agent with potent virucidal activity against simian rotavirus and bovine coronavirus Article Swipe
Walaa H. Salama
,
Mohamed N. F. Shaheen
,
Yasser E. Shahein
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1007/s00203-022-03139-7
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1007/s00203-022-03139-7
Viral infections are linked to a variety of human diseases. Despite the achievements made in drug and vaccine development, several viruses still lack preventive vaccines and efficient antiviral compounds. Thus, developing novel antiviral agents is of great concern, particularly the natural products that are promising candidates for such discoveries. In this study, we have purified an approximately 15 kDa basic phospholipase A2 (PLA2) enzyme from the Egyptian cobra Naja haje haje venom. The purified N. haje PLA2 showed a specific activity of 22 units/mg protein against 6 units/mg protein for the whole crude venom with 3.67-fold purification. The antiviral activity of purified N. haje PLA2 has been investigated in vitro against bovine coronavirus (BCoV) and simian rotavirus (RV SA-11). Our results showed that the CC 50 of PLA2 were 33.6 and 29 µg/ml against MDBK and MA104 cell lines, respectively. Antiviral analysis of N . haje PLA2 showed an inhibition of BCoV and RV SA-11 infections with a therapeutic index equal to 33.6 and 16, respectively. Moreover, N. haje PLA2 decreased the BCoV and RV SA-11 titers by 4.25 log 10 TCID 50 and 2.5 log 10 TCID 50 , respectively. Thus, this research suggests the potential antiviral activity of purified N. haje PLA2 against BCoV and RV SA-11 infections in vitro .
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00203-022-03139-7
- https://link.springer.com/content/pdf/10.1007/s00203-022-03139-7.pdf
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All OpenAlex metadata
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https://openalex.org/W4288175822Canonical identifier for this work in OpenAlex
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https://doi.org/10.1007/s00203-022-03139-7Digital Object Identifier
- Title
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Egyptian cobra (Naja haje haje) venom phospholipase A2: a promising antiviral agent with potent virucidal activity against simian rotavirus and bovine coronavirusWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
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2022-07-27Full publication date if available
- Authors
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Walaa H. Salama, Mohamed N. F. Shaheen, Yasser E. ShaheinList of authors in order
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https://doi.org/10.1007/s00203-022-03139-7Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s00203-022-03139-7.pdfDirect link to full text PDF
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s00203-022-03139-7.pdfDirect OA link when available
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Virology, Rotavirus, Microbiology, Biology, VirusTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2024: 3, 2023: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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