Eicosanoids in human heart failure: pilot study of plasma epoxyeicosatrienoic and dihydroxyeicosatrienoic acid levels Article Swipe
Petr Kala
,
Tomáš Hnát
,
Karolína Pádrová
,
Karel Kotaška
,
Josef Veselka
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.5114/aoms/159313
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.5114/aoms/159313
Introduction The role of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, remains unclear in human heart failure (HF). Material and methods We enrolled 50 patients with HF to measure plasma 14,15-EET and 14,15-DHET levels using commercial ELISA kits and compared them with 25 age- and sex-matched controls. Results Both of the measured eicosanoids were significantly higher in the HF group: 14,15-EET (91.3 ±25.7 ng/ml vs. 64.95 ±35.4 ng/ml) and 14,15-DHET (10.58 ±2.06 ng/ml vs. 9.07 ±1.60 ng/ml), p for both < 0.001. Conclusions We found that peripheral plasma eicosanoid (14,15-EET, 14,15-DHET) levels are raised in patients with HF compared to age- and sex-matched controls.
Related Topics
Concepts
Medicine
Eicosanoid
Arachidonic acid
Epoxyeicosatrienoic acid
Internal medicine
Heart failure
Endocrinology
Human plasma
Plasma levels
Metabolism
Enzyme
Cytochrome P450
Biochemistry
Chromatography
Chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5114/aoms/159313
- https://www.archivesofmedicalscience.com/pdf-159313-88417?filename=Eicosanoids in human.pdf
- OA Status
- gold
- Cited By
- 5
- References
- 14
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4327587075
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4327587075Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5114/aoms/159313Digital Object Identifier
- Title
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Eicosanoids in human heart failure: pilot study of plasma epoxyeicosatrienoic and dihydroxyeicosatrienoic acid levelsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-06Full publication date if available
- Authors
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Petr Kala, Tomáš Hnát, Karolína Pádrová, Karel Kotaška, Josef VeselkaList of authors in order
- Landing page
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https://doi.org/10.5114/aoms/159313Publisher landing page
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https://www.archivesofmedicalscience.com/pdf-159313-88417?filename=Eicosanoids in human.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.archivesofmedicalscience.com/pdf-159313-88417?filename=Eicosanoids in human.pdfDirect OA link when available
- Concepts
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Medicine, Eicosanoid, Arachidonic acid, Epoxyeicosatrienoic acid, Internal medicine, Heart failure, Endocrinology, Human plasma, Plasma levels, Metabolism, Enzyme, Cytochrome P450, Biochemistry, Chromatography, ChemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
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2025: 3, 2024: 2Per-year citation counts (last 5 years)
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14Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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