eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction Article Swipe
YongTian Liang
,
Chengji Piao
,
Christine B. Beuschel
,
David Toppe
,
Laxmikanth Kollipara
,
Boris Bogdanow
,
Marta Maglione
,
Janine Lützkendorf
,
Jason Chun Kit See
,
Sheng Huang
,
Tim Conrad
,
Ulrich Kintscher
,
Frank Madeo
,
Fan Liu
,
Albert Sickmann
,
Stephan J. Sigrist
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2021.108941
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2021.108941
Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mitochondrial respiration and delay aspects of brain aging. Spermidine serves as the amino-butyl group donor for the synthesis of hypusine (Nε-[4-amino-2-hydroxybutyl]-lysine) at a specific lysine residue of the eukaryotic translation initiation factor 5A (eIF5A). Here, we show that in the Drosophila brain, hypusinated eIF5A levels decline with age but can be boosted by dietary spermidine. Several genetic regimes of attenuating eIF5A hypusination all similarly affect brain mitochondrial respiration resembling age-typical mitochondrial decay and also provoke a premature aging of locomotion and memory formation in adult Drosophilae. eIF5A hypusination, conserved through all eukaryotes as an obviously critical effector of spermidine, might thus be an important diagnostic and therapeutic avenue in aspects of brain aging provoked by mitochondrial decline.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2021.108941
- http://www.cell.com/article/S2211124721002552/pdf
- OA Status
- gold
- Cited By
- 112
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3154641364
All OpenAlex metadata
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- OpenAlex ID
-
https://openalex.org/W3154641364Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.celrep.2021.108941Digital Object Identifier
- Title
-
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunctionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-04-01Full publication date if available
- Authors
-
YongTian Liang, Chengji Piao, Christine B. Beuschel, David Toppe, Laxmikanth Kollipara, Boris Bogdanow, Marta Maglione, Janine Lützkendorf, Jason Chun Kit See, Sheng Huang, Tim Conrad, Ulrich Kintscher, Frank Madeo, Fan Liu, Albert Sickmann, Stephan J. SigristList of authors in order
- Landing page
-
https://doi.org/10.1016/j.celrep.2021.108941Publisher landing page
- PDF URL
-
https://www.cell.com/article/S2211124721002552/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.cell.com/article/S2211124721002552/pdfDirect OA link when available
- Concepts
-
Spermidine, Biology, Brain aging, Mitochondrion, Cognitive decline, Endogeny, Neurodegeneration, Cell biology, Biochemistry, Internal medicine, Neuroscience, Medicine, Cognition, Enzyme, Dementia, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
112Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 33, 2024: 19, 2023: 29, 2022: 24, 2021: 7Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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