Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems Article Swipe
Agnes‐Valencia Weiss
,
Marc Schneider
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3762/bjnano.14.95
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3762/bjnano.14.95
Nanoparticles have shown an enormous potential as drug delivery systems in the lab. However, translation to the clinics or even market approval often fails. So far, the reason for this discrepancy is manifold. Physicochemical properties such as size, surface potential, and surface chemistry are in focus of research for many years. Other equally important parameters, influencing whether a successful drug delivery can be achieved, are mechanical properties of nanoparticles. Even though this is often not even considered during formulation development, and it is not requested for approval, an increasing number of studies show that it is important to have knowledge about these characteristics. In this article, we discuss examples highlighting the influence of elasticity in nanoscale biological interactions focusing on mucosal delivery and on tumor targeting. Besides this, we discuss the influence of different measurement settings using atomic force microscopy for the determination of mechanical properties of drug carriers.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3762/bjnano.14.95
- https://www.beilstein-journals.org/bjnano/content/pdf/2190-4286-14-95.pdf
- OA Status
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- Cited By
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- OpenAlex ID
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Raw OpenAlex JSON
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- DOI
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https://doi.org/10.3762/bjnano.14.95Digital Object Identifier
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Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systemsWork title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-11-23Full publication date if available
- Authors
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Agnes‐Valencia Weiss, Marc SchneiderList of authors in order
- Landing page
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https://doi.org/10.3762/bjnano.14.95Publisher landing page
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https://www.beilstein-journals.org/bjnano/content/pdf/2190-4286-14-95.pdfDirect link to full text PDF
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diamondOpen access status per OpenAlex
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https://www.beilstein-journals.org/bjnano/content/pdf/2190-4286-14-95.pdfDirect OA link when available
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Drug delivery, Elasticity (physics), Nanotechnology, Nanoscopic scale, Nanoparticle, Atomic force microscopy, Targeted drug delivery, Materials science, Biochemical engineering, Composite material, EngineeringTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 2, 2024: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W4282002836, https://openalex.org/W4317905177, https://openalex.org/W3109746568, https://openalex.org/W2127410754, https://openalex.org/W3207886513, https://openalex.org/W3133511640, https://openalex.org/W4283033674, https://openalex.org/W2991091521, https://openalex.org/W2941157893, https://openalex.org/W2909064040, https://openalex.org/W2039432298, https://openalex.org/W2805390049, https://openalex.org/W2331510077, https://openalex.org/W19822677, https://openalex.org/W3106774842, https://openalex.org/W2284054021, https://openalex.org/W4307906577, https://openalex.org/W4281555369, https://openalex.org/W2048576850, https://openalex.org/W2089642314, https://openalex.org/W3022830848, https://openalex.org/W4292198312, https://openalex.org/W2079508597, https://openalex.org/W1968982832, https://openalex.org/W2146202010, https://openalex.org/W2043418691, https://openalex.org/W3042439904, https://openalex.org/W2030574023, https://openalex.org/W3089723463, https://openalex.org/W4312030578, https://openalex.org/W4293791114, https://openalex.org/W2782175732, https://openalex.org/W3105191425, https://openalex.org/W2946512789, https://openalex.org/W2923478127, https://openalex.org/W4313647187, https://openalex.org/W3005898111, https://openalex.org/W2811460842, https://openalex.org/W4283641322, https://openalex.org/W3082792203, https://openalex.org/W2957441737, https://openalex.org/W2889274053, https://openalex.org/W4327740406 |
| referenced_works_count | 43 |
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