Electrochemical Amination of Aryl Halides with NH₃ Article Swipe

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Amination Primary (astronomy) Aryl Halide Chemistry Nucleophile Halogen Reagent Electrochemistry Combinatorial chemistry Ammonia Atom economy Organic chemistry Organic synthesis Catalysis Electrode Physics Astronomy Alkyl Physical chemistry

Yaowen Liu , Yanfei Sun , Yuan Deng , Youai Qiu ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1002/anie.202504459 · OA: W4409296749

Primary arylamines are the most pivotal class of organic motifs in pharmaceuticals, agrochemicals, ligands and natural products. Ammonia (NH 3 ) is an ideal nitrogen source in terms of reactivity, atom economy, and environmental compatibility. Despite significant progress in the synthesis of primary arylamines, the development of a general method for rapid access to diversely functionalized primary arylamines is still urgent and necessary. Herein, we developed a method for the direct synthesis of primary arylamines through electrochemical amination of aryl halides with NH 3 . Notably, the weak nucleophilic reagent NH 3 was directly used as an ammonia surrogate, allowing for efficient conversion of carbon‐halogen bonds to diverse primary arylamines with good functional group tolerance. A broad scope of functionalized primary arylamines has been achieved in moderate to excellent yields.