Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration Article Swipe
Lei Miao
,
Haitao Liao
,
Shijia Wang
,
Hang Zhou
,
Jianwei Zhu
,
Haoran Wan
,
Gregory F. Payne
,
Changsheng Liu
,
Xue Qu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202307606
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202307606
Biology remains the envy of flexible soft matter fabrication because it can satisfy multiple functional needs by organizing a small set of proteins and polysaccharides into hierarchical systems with controlled heterogeneity in composition and microstructure. Here, it is reported that controlled, mild electronic inputs (<10 V; <20 min) induce a homogeneous gelatin‐chitosan mixture to undergo sorting and bottom‐up self‐assembly into a Janus film with compositional gradient (i.e., from chitosan‐enriched layer to chitosan/gelatin‐contained layer) and tunable dense‐porous gradient microstructures (e.g., porosity, pore size, and ratio of dense to porous layers). This Janus film performs is shown multiple functions for guided bone regeneration: the integration of compositional and microstructural features confers flexible mechanics, asymmetric properties for interfacial wettability, molecular transport (directional growth factor release), and cellular responses (prevents fibroblast infiltration but promotes osteoblast growth and differentiation). Overall, this work demonstrates the versatility of electrofabrication for the customized manufacturing of functional gradient soft matter.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/advs.202307606
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202307606
- OA Status
- gold
- Cited By
- 56
- References
- 76
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390917513
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390917513Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/advs.202307606Digital Object Identifier
- Title
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Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone RegenerationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-15Full publication date if available
- Authors
-
Lei Miao, Haitao Liao, Shijia Wang, Hang Zhou, Jianwei Zhu, Haoran Wan, Gregory F. Payne, Changsheng Liu, Xue QuList of authors in order
- Landing page
-
https://doi.org/10.1002/advs.202307606Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202307606Direct link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202307606Direct OA link when available
- Concepts
-
Materials science, Microstructure, Soft matter, Janus, Gelatin, Porosity, Nanotechnology, Chitosan, Wetting, Fabrication, Chemical engineering, Composite material, Chemistry, Pathology, Colloid, Alternative medicine, Engineering, Medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
56Total citation count in OpenAlex
- Citations by year (recent)
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2025: 14, 2024: 42Per-year citation counts (last 5 years)
- References (count)
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76Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.compositional | 65, 105 |
| abstract_inverted_index.heterogeneity | 31 |
| abstract_inverted_index.manufacturing | 146 |
| abstract_inverted_index.regeneration: | 101 |
| abstract_inverted_index.dense‐porous | 76 |
| abstract_inverted_index.microstructural | 107 |
| abstract_inverted_index.microstructure. | 35 |
| abstract_inverted_index.microstructures | 78 |
| abstract_inverted_index.polysaccharides | 25 |
| abstract_inverted_index.self‐assembly | 59 |
| abstract_inverted_index.differentiation). | 134 |
| abstract_inverted_index.electrofabrication | 142 |
| abstract_inverted_index.gelatin‐chitosan | 52 |
| abstract_inverted_index.chitosan‐enriched | 69 |
| abstract_inverted_index.chitosan/gelatin‐contained | 72 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 99 |
| corresponding_author_ids | https://openalex.org/A5011944721, https://openalex.org/A5110102697 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I143593769 |
| citation_normalized_percentile.value | 0.99481825 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |