Elevated binding and functional antibody responses to SARS-CoV-2 in infants versus mothers Article Swipe
Caitlin I. Stoddard
,
Kevin Sung
,
Zak A. Yaffe
,
Haidyn Weight
,
Guillaume Beaudoin-Bussières
,
Jared Galloway
,
Soren Gantt
,
Judith Adhiambo
,
Emily R. Begnel
,
Ednah Ojee
,
Jennifer A. Slyker
,
Dalton Wamalwa
,
John Kinuthia
,
Andrés Finzi
,
F. A. Matsen
,
Dara A. Lehman
,
Julie Overbaugh
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.02.06.527330
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.02.06.527330
Summary Infant antibody responses to viral infection can differ from those in adults. However, data on the specificity and function of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in infants, and direct comparisons between infants and adults are limited. We characterized antibody binding and functionality in convalescent plasma from postpartum women and their infants infected with SARS-CoV-2 from a vaccine-naïve prospective cohort in Nairobi, Kenya. Antibody titers against SARS-CoV-2 Spike, receptor binding domain and N-terminal domain, and Spike-expressing cell-surface staining levels were significantly higher in infants than in mothers. Plasma antibodies from mothers and infants bound to similar regions of the Spike S2 subunit, including the fusion peptide (FP) and stem helix-heptad repeat 2. However, infants displayed higher antibody levels and more consistent antibody escape pathways in the FP region compared to mothers. Finally, infants had significantly higher levels of antibody-dependent cellular cytotoxicity (ADCC), though, surprisingly, neutralization titers between infants and mothers were similar. These results suggest infants develop distinct SARS-CoV-2 binding and functional antibody repertoires and reveal age-related differences in humoral immunity to SARS-CoV-2 infection that could be relevant to protection and COVID-19 disease outcomes.
Related Topics
Concepts
Antibody
Antibody-dependent cell-mediated cytotoxicity
Immunology
Antibody titer
Medicine
Titer
Vaccine trial
Neutralization
Virology
Biology
Monoclonal antibody
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.02.06.527330
- https://www.biorxiv.org/content/biorxiv/early/2023/02/07/2023.02.06.527330.full.pdf
- OA Status
- green
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319337123
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4319337123Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.02.06.527330Digital Object Identifier
- Title
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Elevated binding and functional antibody responses to SARS-CoV-2 in infants versus mothersWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-02-07Full publication date if available
- Authors
-
Caitlin I. Stoddard, Kevin Sung, Zak A. Yaffe, Haidyn Weight, Guillaume Beaudoin-Bussières, Jared Galloway, Soren Gantt, Judith Adhiambo, Emily R. Begnel, Ednah Ojee, Jennifer A. Slyker, Dalton Wamalwa, John Kinuthia, Andrés Finzi, F. A. Matsen, Dara A. Lehman, Julie OverbaughList of authors in order
- Landing page
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https://doi.org/10.1101/2023.02.06.527330Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2023/02/07/2023.02.06.527330.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2023/02/07/2023.02.06.527330.full.pdfDirect OA link when available
- Concepts
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Antibody, Antibody-dependent cell-mediated cytotoxicity, Immunology, Antibody titer, Medicine, Titer, Vaccine trial, Neutralization, Virology, Biology, Monoclonal antibodyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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64Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W3159965848, https://openalex.org/W4205170082, https://openalex.org/W2090477263, https://openalex.org/W4206905345, https://openalex.org/W3201465512, https://openalex.org/W4316928395, https://openalex.org/W3044321933, https://openalex.org/W4210430000, https://openalex.org/W3091039991, https://openalex.org/W3020828664, https://openalex.org/W4308443024, https://openalex.org/W3131055609, https://openalex.org/W4304203302, https://openalex.org/W2605897695, https://openalex.org/W4283723170, https://openalex.org/W4200549897, https://openalex.org/W3121906900, https://openalex.org/W3024514613, https://openalex.org/W3157704466, https://openalex.org/W4206917016, https://openalex.org/W3090784217, https://openalex.org/W3166838531, https://openalex.org/W4281843570, https://openalex.org/W2047426399, https://openalex.org/W3127852352, https://openalex.org/W4281559006, https://openalex.org/W2604239613, https://openalex.org/W3205703631, https://openalex.org/W3013891156, https://openalex.org/W4220662974, https://openalex.org/W2170551349, https://openalex.org/W3084156220, https://openalex.org/W2262193295, https://openalex.org/W2159401087, https://openalex.org/W2582689618, https://openalex.org/W1990426998, https://openalex.org/W3086125063, https://openalex.org/W3087440122, https://openalex.org/W3192545069, https://openalex.org/W3031830637, https://openalex.org/W4226000943, https://openalex.org/W4281653412, https://openalex.org/W2767776597, https://openalex.org/W3125433020, https://openalex.org/W4285993171, https://openalex.org/W3091214020, https://openalex.org/W3157689722, https://openalex.org/W4285093040, https://openalex.org/W3172271359, https://openalex.org/W3207509824, https://openalex.org/W3195868522, https://openalex.org/W2134206097, https://openalex.org/W3096205573, https://openalex.org/W4223415813, https://openalex.org/W3156400748, https://openalex.org/W3136275452, https://openalex.org/W3202903389, https://openalex.org/W3014656992, https://openalex.org/W4226149440, https://openalex.org/W4221132542, https://openalex.org/W4380853125, https://openalex.org/W4211175809, https://openalex.org/W2952045272, https://openalex.org/W3029682964 |
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| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5061366174, https://openalex.org/A5075328638 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 17 |
| corresponding_institution_ids | https://openalex.org/I1326427960, https://openalex.org/I201448701, https://openalex.org/I4210089486 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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