Elevated Blood Pressure Occurs without Endothelial Dysfunction in a Rat Model of Pulmonary Emphysema Article Swipe
Elodie Desplanche
,
Pierre-Edouard Grillet
,
Quentin Wynands
,
Patrice Bideaux
,
Laurie Alburquerque
,
Azzouz Charrabi
,
Arnaud Bourdin
,
Olivier Cazorla
,
Farès Gouzi
,
Anne Virsolvy
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241612609
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241612609
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease involving airway closure and parenchyma destruction (emphysema). Cardiovascular diseases are the main causes of morbi-mortality in COPD and, in particular, hypertension and heart failure with preserved ejection fraction (HFpEF). However, no mechanistic link has currently been established between the onset of COPD, elevated blood pressure (BP) and systemic vascular impairment (endothelial dysfunction). Thus, we aimed to characterize BP and vascular function and remodeling in a rat model of exacerbated emphysema focusing on the role of sympathetic hyperactivity. Emphysema was induced in male Wistar rats by four weekly pulmonary instillations of elastase (4UI) and exacerbation by a single dose of lipopolysaccharides (LPS). Five weeks following the last instillation, in vivo and ex vivo cardiac and vascular functions were investigated. Exacerbated emphysema induced cardiac dysfunction (HFpEF) and a BP increase in this COPD model. We observed vasomotor changes and hypotrophic remodeling of the aorta without endothelial dysfunction. Indeed, changes in contractile and vasorelaxant properties, though endothelium-dependent, were pro-relaxant and NO-independent. A β1-receptor antagonist (bisoprolol) prevented HFpEF and vascular adaptations, while the effect on BP increase was partial. Endothelial dysfunction would not trigger hypertension and HFpEF in COPD. Vascular changes appeared as an adaptation to the increased BP. The preventing effect of bisoprolol revealed a pivotal role of sympathetic hyperactivation in BP elevation. The mechanistic link between HFpEF, cardiac sympathetic activation and BP deserves further studies in this exacerbated-emphysema model, as well as in COPD patients.
Related Topics
Concepts
Medicine
COPD
Cardiology
Endothelial dysfunction
Internal medicine
Heart failure with preserved ejection fraction
Heart failure
Blood pressure
Pulmonary hypertension
Endothelium
Bisoprolol
Ejection fraction
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms241612609
- https://www.mdpi.com/1422-0067/24/16/12609/pdf?version=1691579706
- OA Status
- gold
- Cited By
- 3
- References
- 65
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385704461
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385704461Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms241612609Digital Object Identifier
- Title
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Elevated Blood Pressure Occurs without Endothelial Dysfunction in a Rat Model of Pulmonary EmphysemaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-08-09Full publication date if available
- Authors
-
Elodie Desplanche, Pierre-Edouard Grillet, Quentin Wynands, Patrice Bideaux, Laurie Alburquerque, Azzouz Charrabi, Arnaud Bourdin, Olivier Cazorla, Farès Gouzi, Anne VirsolvyList of authors in order
- Landing page
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https://doi.org/10.3390/ijms241612609Publisher landing page
- PDF URL
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https://www.mdpi.com/1422-0067/24/16/12609/pdf?version=1691579706Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/24/16/12609/pdf?version=1691579706Direct OA link when available
- Concepts
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Medicine, COPD, Cardiology, Endothelial dysfunction, Internal medicine, Heart failure with preserved ejection fraction, Heart failure, Blood pressure, Pulmonary hypertension, Endothelium, Bisoprolol, Ejection fractionTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
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2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
65Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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