Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota Article Swipe
Carolina Serena
,
Victòria Ceperuelo‐Mallafré
,
Noelia Keiran
,
María Isabel Queipo‐Ortuño
,
Rosa Bernal
,
Ricardo Gómez-Huelgas
,
Mireia Urpí-Sardá
,
Mònica Sabater
,
Vicente Pérez‐Brocal
,
Cristina Andrés‐Lacueva
,
Andrés Moyá
,
Francisco J. Tinahones
,
José Manuel Fernández‐Real
,
Joan Vendrell
,
Sonia Fernández‐Veledo
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1038/s41396-018-0068-2
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1038/s41396-018-0068-2
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe–microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41396-018-0068-2
- https://www.nature.com/articles/s41396-018-0068-2.pdf
- OA Status
- hybrid
- Cited By
- 374
- References
- 81
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2790440400
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2790440400Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41396-018-0068-2Digital Object Identifier
- Title
-
Elevated circulating levels of succinate in human obesity are linked to specific gut microbiotaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-02-06Full publication date if available
- Authors
-
Carolina Serena, Victòria Ceperuelo‐Mallafré, Noelia Keiran, María Isabel Queipo‐Ortuño, Rosa Bernal, Ricardo Gómez-Huelgas, Mireia Urpí-Sardá, Mònica Sabater, Vicente Pérez‐Brocal, Cristina Andrés‐Lacueva, Andrés Moyá, Francisco J. Tinahones, José Manuel Fernández‐Real, Joan Vendrell, Sonia Fernández‐VeledoList of authors in order
- Landing page
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https://doi.org/10.1038/s41396-018-0068-2Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41396-018-0068-2.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41396-018-0068-2.pdfDirect OA link when available
- Concepts
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Gut flora, Biology, Metabolite, Microbiome, Obesity, Type 2 diabetes, Overweight, Internal medicine, Endocrinology, Diabetes mellitus, Microbiology, Immunology, Bioinformatics, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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374Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 46, 2024: 57, 2023: 67, 2022: 56, 2021: 63Per-year citation counts (last 5 years)
- References (count)
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81Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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