Elevated glucose alters eicosanoid release from porcine aortic endothelial cells. Article Swipe
Michael L. Brown
,
J.A. Jakubowski
,
Lynn L. Leventis
,
Daniel Deykin
·
YOU?
·
· 1988
· Open Access
·
· DOI: https://doi.org/10.1172/jci113835
YOU?
·
· 1988
· Open Access
·
· DOI: https://doi.org/10.1172/jci113835
Cultured porcine aortic endothelial cells were conditioned through two passages to mimic euglycemic and hyperglycemic conditions (5.2 mM, normal glucose; 15.6 mM, elevated glucose). After incubation with 1 microM [14C]arachidonic acid for 24 h, the cells were stimulated with 1 microM A23187 for times up to 30 min. Uptake of [14C]arachidonic acid and its distribution among cell lipids were unaffected by the increased glucose concentration. The release of eicosanoids from labeled cells and unlabeled cells was measured by reverse-phase HPLC and by RIA, respectively. Compared with cells stimulated in the presence of normal glucose concentrations, cells stimulated in the presence of elevated glucose released 62.6% less free [14C]arachidonic acid, but released 129% more 14C-labeled 15-hydroxyeicosatetraenoic acid (HETE). Increased release of 15-HETE in the presence of elevated glucose in response to A23187, bradykinin, and thrombin was confirmed by RIA. A similar increase in 5-HETE release was observed by RIA after A23187 treatment. The release of both radiolabeled and unlabeled prostanoids was equal at both glucose concentrations. The data indicate that glucose may play an important role in the regulation of release and metabolism of arachidonic acid after agonist stimulation. In the presence of elevated glucose concentrations, such as those associated with diabetes mellitus, the extent and pattern of eicosanoid release from endothelial cells is markedly altered.
Related Topics
Concepts
Arachidonic acid
Eicosanoid
Internal medicine
Endocrinology
Metabolism
Bradykinin
Chemistry
Eicosanoid metabolism
Carbohydrate metabolism
Biology
Biochemistry
Receptor
Enzyme
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci113835
- http://www.jci.org/articles/view/113835/files/pdf
- OA Status
- bronze
- Cited By
- 47
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W1984123478
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W1984123478Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1172/jci113835Digital Object Identifier
- Title
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Elevated glucose alters eicosanoid release from porcine aortic endothelial cells.Work title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
1988Year of publication
- Publication date
-
1988-12-01Full publication date if available
- Authors
-
Michael L. Brown, J.A. Jakubowski, Lynn L. Leventis, Daniel DeykinList of authors in order
- Landing page
-
https://doi.org/10.1172/jci113835Publisher landing page
- PDF URL
-
https://www.jci.org/articles/view/113835/files/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.jci.org/articles/view/113835/files/pdfDirect OA link when available
- Concepts
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Arachidonic acid, Eicosanoid, Internal medicine, Endocrinology, Metabolism, Bradykinin, Chemistry, Eicosanoid metabolism, Carbohydrate metabolism, Biology, Biochemistry, Receptor, Enzyme, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
47Total citation count in OpenAlex
- Citations by year (recent)
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2016: 1Per-year citation counts (last 5 years)
- References (count)
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24Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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