Elevation in blood flow and shear rate prevents hyperglycemia-induced endothelial dysfunction in healthy subjects and those with type 2 diabetes Article Swipe
Arno Greyling
,
Tim H.A. Schreuder
,
Thijs Landman
,
Richard Draijer
,
Rebecca J. H. M. Verheggen
,
Maria T. E. Hopman
,
Dick H. J. Thijssen
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1152/japplphysiol.00936.2014
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1152/japplphysiol.00936.2014
Hyperglycemia, commonly present after a meal, causes transient impairment in endothelial function. We examined whether increases in blood flow (BF) protect against the hyperglycemia-mediated decrease in endothelial function in healthy subjects and patients with type 2 diabetes mellitus (T2DM). Ten healthy subjects and 10 age- and sex-matched patients with T2DM underwent simultaneous bilateral assessment of brachial artery endothelial function by means of flow-mediated dilation (FMD) using high-resolution echo-Doppler. FMD was examined before and 60, 120, and 150 min after a 75-g oral glucose challenge. We unilaterally manipulated BF by heating one arm between minute 30 and minute 60. Oral glucose administration caused a statistically significant, transient increase in blood glucose in both groups ( P < 0.001). Forearm skin temperature, brachial artery BF, and shear rate significantly increased in the heated arm ( P < 0.001), and to a greater extent compared with the nonheated arm in both groups (interaction effect P < 0.001). The glucose load caused a transient decrease in FMD% ( P < 0.05), whereas heating significantly prevented the decline (interaction effect P < 0.01). Also, when correcting for changes in diameter and shear rate, we found that the hyperglycemia-induced decrease in FMD can be prevented by local heating ( P < 0.05). These effects on FMD were observed in both groups. Our data indicate that nonmetabolically driven elevation in BF and shear rate can similarly prevent the hyperglycemia-induced decline in conduit artery endothelial function in healthy volunteers and in patients with type 2 diabetes. Additional research is warranted to confirm that other interventions that increase BF and shear rate equally protect the endothelium when challenged by hyperglycemia.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/japplphysiol.00936.2014
- OA Status
- green
- Cited By
- 24
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2156478672
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2156478672Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1152/japplphysiol.00936.2014Digital Object Identifier
- Title
-
Elevation in blood flow and shear rate prevents hyperglycemia-induced endothelial dysfunction in healthy subjects and those with type 2 diabetesWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2015Year of publication
- Publication date
-
2015-01-16Full publication date if available
- Authors
-
Arno Greyling, Tim H.A. Schreuder, Thijs Landman, Richard Draijer, Rebecca J. H. M. Verheggen, Maria T. E. Hopman, Dick H. J. ThijssenList of authors in order
- Landing page
-
https://doi.org/10.1152/japplphysiol.00936.2014Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://researchonline.ljmu.ac.uk/id/eprint/2690/3/Fig-1_re-sub.pdfDirect OA link when available
- Concepts
-
Brachial artery, Medicine, Internal medicine, Endothelial dysfunction, Endocrinology, Blood flow, Cardiology, Diabetes mellitus, Type 2 diabetes, Endothelium, Artery, Forearm, Type 2 Diabetes Mellitus, Blood pressure, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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24Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2022: 3, 2021: 1, 2020: 4, 2019: 4Per-year citation counts (last 5 years)
- References (count)
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48Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.These | 206 |
| abstract_inverted_index.after | 3, 78 |
| abstract_inverted_index.blood | 17, 108 |
| abstract_inverted_index.found | 189 |
| abstract_inverted_index.local | 200 |
| abstract_inverted_index.meal, | 5 |
| abstract_inverted_index.means | 60 |
| abstract_inverted_index.other | 255 |
| abstract_inverted_index.rate, | 187 |
| abstract_inverted_index.shear | 124, 186, 225, 261 |
| abstract_inverted_index.using | 65 |
| abstract_inverted_index.0.01). | 177 |
| abstract_inverted_index.0.05), | 166 |
| abstract_inverted_index.0.05). | 205 |
| abstract_inverted_index.artery | 56, 121, 235 |
| abstract_inverted_index.before | 71 |
| abstract_inverted_index.caused | 101, 157 |
| abstract_inverted_index.causes | 6 |
| abstract_inverted_index.driven | 220 |
| abstract_inverted_index.effect | 150, 174 |
| abstract_inverted_index.extent | 140 |
| abstract_inverted_index.groups | 112, 148 |
| abstract_inverted_index.heated | 130 |
| abstract_inverted_index.minute | 93, 96 |
| abstract_inverted_index.(T2DM). | 38 |
| abstract_inverted_index.0.001), | 135 |
| abstract_inverted_index.0.001). | 116, 153 |
| abstract_inverted_index.Forearm | 117 |
| abstract_inverted_index.against | 21 |
| abstract_inverted_index.between | 92 |
| abstract_inverted_index.changes | 182 |
| abstract_inverted_index.conduit | 234 |
| abstract_inverted_index.confirm | 253 |
| abstract_inverted_index.decline | 172, 232 |
| abstract_inverted_index.effects | 207 |
| abstract_inverted_index.equally | 263 |
| abstract_inverted_index.glucose | 82, 99, 109, 155 |
| abstract_inverted_index.greater | 139 |
| abstract_inverted_index.groups. | 214 |
| abstract_inverted_index.healthy | 29, 40, 239 |
| abstract_inverted_index.heating | 89, 168, 201 |
| abstract_inverted_index.present | 2 |
| abstract_inverted_index.prevent | 229 |
| abstract_inverted_index.protect | 20, 264 |
| abstract_inverted_index.whereas | 167 |
| abstract_inverted_index.whether | 14 |
| abstract_inverted_index.brachial | 55, 120 |
| abstract_inverted_index.commonly | 1 |
| abstract_inverted_index.compared | 141 |
| abstract_inverted_index.decrease | 24, 160, 193 |
| abstract_inverted_index.diabetes | 36 |
| abstract_inverted_index.diameter | 184 |
| abstract_inverted_index.dilation | 63 |
| abstract_inverted_index.examined | 13, 70 |
| abstract_inverted_index.function | 27, 58, 237 |
| abstract_inverted_index.increase | 106, 258 |
| abstract_inverted_index.indicate | 217 |
| abstract_inverted_index.mellitus | 37 |
| abstract_inverted_index.observed | 211 |
| abstract_inverted_index.patients | 32, 47, 243 |
| abstract_inverted_index.research | 249 |
| abstract_inverted_index.subjects | 30, 41 |
| abstract_inverted_index.bilateral | 52 |
| abstract_inverted_index.diabetes. | 247 |
| abstract_inverted_index.elevation | 221 |
| abstract_inverted_index.function. | 11 |
| abstract_inverted_index.increased | 127 |
| abstract_inverted_index.increases | 15 |
| abstract_inverted_index.nonheated | 144 |
| abstract_inverted_index.prevented | 170, 198 |
| abstract_inverted_index.similarly | 228 |
| abstract_inverted_index.transient | 7, 105, 159 |
| abstract_inverted_index.underwent | 50 |
| abstract_inverted_index.warranted | 251 |
| abstract_inverted_index.Additional | 248 |
| abstract_inverted_index.assessment | 53 |
| abstract_inverted_index.challenge. | 83 |
| abstract_inverted_index.challenged | 268 |
| abstract_inverted_index.correcting | 180 |
| abstract_inverted_index.impairment | 8 |
| abstract_inverted_index.volunteers | 240 |
| abstract_inverted_index.endothelial | 10, 26, 57, 236 |
| abstract_inverted_index.endothelium | 266 |
| abstract_inverted_index.manipulated | 86 |
| abstract_inverted_index.sex-matched | 46 |
| abstract_inverted_index.(interaction | 149, 173 |
| abstract_inverted_index.significant, | 104 |
| abstract_inverted_index.simultaneous | 51 |
| abstract_inverted_index.temperature, | 119 |
| abstract_inverted_index.unilaterally | 85 |
| abstract_inverted_index.echo-Doppler. | 67 |
| abstract_inverted_index.flow-mediated | 62 |
| abstract_inverted_index.interventions | 256 |
| abstract_inverted_index.significantly | 126, 169 |
| abstract_inverted_index.statistically | 103 |
| abstract_inverted_index.Hyperglycemia, | 0 |
| abstract_inverted_index.administration | 100 |
| abstract_inverted_index.hyperglycemia. | 270 |
| abstract_inverted_index.high-resolution | 66 |
| abstract_inverted_index.nonmetabolically | 219 |
| abstract_inverted_index.hyperglycemia-induced | 192, 231 |
| abstract_inverted_index.hyperglycemia-mediated | 23 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5030975081 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I145872427, https://openalex.org/I2802934949, https://openalex.org/I63098007 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.88336592 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |