Journal of Applied Physiology • Vol 118 • No 5
Elevation in blood flow and shear rate prevents hyperglycemia-induced endothelial dysfunction in healthy subjects and those with type 2 diabetes
January 2015 • Arno Greyling, Tim H.A. Schreuder, Thijs Landman, Richard Draijer, Rebecca J. H. M. Verheggen, Maria T. E. Hopman, Dick H. J. Thijssen
Hyperglycemia, commonly present after a meal, causes transient impairment in endothelial function. We examined whether increases in blood flow (BF) protect against the hyperglycemia-mediated decrease in endothelial function in healthy subjects and patients with type 2 diabetes mellitus (T2DM). Ten healthy subjects and 10 age- and sex-matched patients with T2DM underwent simultaneous bilateral assessment of brachial artery endothelial function by means of flow-mediated dilation (FMD) using high-resolution echo-Dopp…