eLife Assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish Article Swipe
In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory axons reorganize their terminal arborization patterns to establish precise neural microcircuits around the mechanosensory hair cells. However, a quantitative understanding of the changes in the sensory arbor morphology and the regulators behind the microcircuit assembly remain enigmatic. Here, we report that Semaphorin7A (Sema7A) acts as an important mediator of these processes. Utilizing a semi-automated three-dimensional neurite tracing methodology and computational techniques, we have identified and quantitatively analyzed distinct topological features that shape the network in wild-type and Sema7A loss-of-function mutants. In contrast to those of wild-type animals, the sensory axons in Sema7A mutants display aberrant arborizations with disorganized network topology and diminished contacts to hair cells. Moreover, ectopic expression of a secreted form of Sema7A by non-hair cells induces chemotropic guidance of sensory axons. Our findings propose that Sema7A likely functions both as a juxtracrine and as a secreted cue to pattern neural circuitry during sensory organ development.
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Metadata
- Type
- peer-review
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.89926.3.sa4
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
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https://openalex.org/W4397004208Canonical identifier for this work in OpenAlex
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https://doi.org/10.7554/elife.89926.3.sa4Digital Object Identifier
- Title
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eLife Assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafishWork title
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peer-reviewOpenAlex work type
- Language
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enPrimary language
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2024Year of publication
- Publication date
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2024-05-17Full publication date if available
- Authors
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David W. RaibleList of authors in order
- Landing page
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https://doi.org/10.7554/elife.89926.3.sa4Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.89926.3.sa4Direct OA link when available
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Zebrafish, Line (geometry), Computer science, Artificial intelligence, Biology, Mathematics, Genetics, Geometry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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