Eliminating Radioresistance With a Magnetic Ion‐Generator by Simultaneously Augmenting DNA Damage and Diminishing Immunosuppression Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.1002/adma.202406378
Radiotherapy (RT) hinges on DNA damage‐induced cancer cell death and the subsequent anti‐tumor immunity. However, the efficacy of RT is curtailed by cell cycle heterogeneity and an immunosuppressive tumor microenvironment, which foster radioresistance. Here an ion generator‐based RT enhancement strategy is demonstrated in a mouse model of the radioresistant tumor. The ion generator is degraded in the tumor microenvironment, resulting in iron‐triggered ferroptosis that enhanced immunogenic cell death and a manganese‐activated stimulator of interferon gene that reversed the immunosuppressive environment. As a result, the proposed strategy promotes dendritic cells maturity, augmentes CD8 + T cell infiltration of tumors, suppresses intratumoral myeloid‐derived suppressor cells, and limits the M2 macrophages polarization, indicating the formation of an immunoreactive microenvironment. Significantly, this approach impedes the growth of not just primary, but also distal metastatic tumors. It is thus believed that the current ion generator provides a robust and enduring countermeasure to radioresistant cancer and its metastasis, with potential implications for enhancing the efficacy of RT in clinically resistant tumors.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adma.202406378
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202406378
- OA Status
- bronze
- Cited By
- 3
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407945014
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407945014Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/adma.202406378Digital Object Identifier
- Title
-
Eliminating Radioresistance With a Magnetic Ion‐Generator by Simultaneously Augmenting DNA Damage and Diminishing ImmunosuppressionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-25Full publication date if available
- Authors
-
Ruru Zhang, Mei Chen, Hui Zhou, Yan Liu, Yi Wang, Can Chen, Yueping Li, Jianfeng Zeng, Jiabin Cui, Ruixue Duan, Mingyuan GaoList of authors in order
- Landing page
-
https://doi.org/10.1002/adma.202406378Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202406378Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202406378Direct OA link when available
- Concepts
-
Radioresistance, Tumor microenvironment, Cancer research, DNA damage, Immunosuppression, Cancer cell, Biology, Radiation therapy, Cancer, Materials science, Immunology, Medicine, DNA, Tumor cells, Internal medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
51Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.augmentes | 91 |
| abstract_inverted_index.curtailed | 21 |
| abstract_inverted_index.dendritic | 88 |
| abstract_inverted_index.enhancing | 157 |
| abstract_inverted_index.formation | 112 |
| abstract_inverted_index.generator | 53, 140 |
| abstract_inverted_index.immunity. | 14 |
| abstract_inverted_index.maturity, | 90 |
| abstract_inverted_index.potential | 154 |
| abstract_inverted_index.resistant | 164 |
| abstract_inverted_index.resulting | 60 |
| abstract_inverted_index.clinically | 163 |
| abstract_inverted_index.indicating | 110 |
| abstract_inverted_index.interferon | 74 |
| abstract_inverted_index.metastatic | 130 |
| abstract_inverted_index.stimulator | 72 |
| abstract_inverted_index.subsequent | 12 |
| abstract_inverted_index.suppresses | 99 |
| abstract_inverted_index.suppressor | 102 |
| abstract_inverted_index.enhancement | 39 |
| abstract_inverted_index.ferroptosis | 63 |
| abstract_inverted_index.immunogenic | 66 |
| abstract_inverted_index.macrophages | 108 |
| abstract_inverted_index.metastasis, | 152 |
| abstract_inverted_index.Radiotherapy | 1 |
| abstract_inverted_index.anti‐tumor | 13 |
| abstract_inverted_index.demonstrated | 42 |
| abstract_inverted_index.environment. | 80 |
| abstract_inverted_index.implications | 155 |
| abstract_inverted_index.infiltration | 96 |
| abstract_inverted_index.intratumoral | 100 |
| abstract_inverted_index.heterogeneity | 25 |
| abstract_inverted_index.polarization, | 109 |
| abstract_inverted_index.Significantly, | 117 |
| abstract_inverted_index.countermeasure | 146 |
| abstract_inverted_index.immunoreactive | 115 |
| abstract_inverted_index.radioresistant | 49, 148 |
| abstract_inverted_index.damage‐induced | 6 |
| abstract_inverted_index.iron‐triggered | 62 |
| abstract_inverted_index.radioresistance. | 33 |
| abstract_inverted_index.generator‐based | 37 |
| abstract_inverted_index.immunosuppressive | 28, 79 |
| abstract_inverted_index.microenvironment, | 30, 59 |
| abstract_inverted_index.microenvironment. | 116 |
| abstract_inverted_index.myeloid‐derived | 101 |
| abstract_inverted_index.manganese‐activated | 71 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5038154663, https://openalex.org/A5071453706, https://openalex.org/A5034584865 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I3923682, https://openalex.org/I4210124971 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96489922 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |