Elucidating Methods for Isolation and Quantification of Exosomes: A Review Article Swipe
Talitha Keren Kurian
,
Soumyabrata Banik
,
Dharshini Gopal
,
Shweta Chakrabarti
,
Nirmal Mazumder
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1007/s12033-021-00300-3
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1007/s12033-021-00300-3
Exosomes are the smallest extracellular vesicles present in most of the biological fluids. They are found to play an important role in cell signaling, immune response, tumor metastasis, etc. Studies have shown that these vesicles also have diagnostic and therapeutic roles for which their accurate detection and quantification is essential. Due to the complexity in size and structure of exosomes, even the gold standard methods face challenges. This comprehensive review discusses the various standard methods such as ultracentrifugation, ultrafiltration, size-exclusion chromatography, precipitation, immunoaffinity, and microfluidic technologies for the isolation of exosomes. The principle of isolation of each method is described, as well as their specific advantages and disadvantages. Quantification of exosomes by nanoparticle tracking analysis, flow cytometry, tunable resistive pulse sensing, electron microscopy, dynamic light scattering, and microfluidic devices are also described, along with the applications of exosomes in various biomedical domains.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1007/s12033-021-00300-3
- https://link.springer.com/content/pdf/10.1007/s12033-021-00300-3.pdf
- OA Status
- hybrid
- Cited By
- 165
- References
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W3121325113Canonical identifier for this work in OpenAlex
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https://doi.org/10.1007/s12033-021-00300-3Digital Object Identifier
- Title
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Elucidating Methods for Isolation and Quantification of Exosomes: A ReviewWork title
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reviewOpenAlex work type
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enPrimary language
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2021Year of publication
- Publication date
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2021-01-25Full publication date if available
- Authors
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Talitha Keren Kurian, Soumyabrata Banik, Dharshini Gopal, Shweta Chakrabarti, Nirmal MazumderList of authors in order
- Landing page
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https://doi.org/10.1007/s12033-021-00300-3Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s12033-021-00300-3.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s12033-021-00300-3.pdfDirect OA link when available
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Microvesicles, Isolation (microbiology), Computational biology, Biology, Bioinformatics, microRNA, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
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165Total citation count in OpenAlex
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2025: 50, 2024: 37, 2023: 25, 2022: 29, 2021: 24Per-year citation counts (last 5 years)
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184Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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