Embryo morphokinetics derived from fresh and vitrified bovine oocytes predict blastocyst development and nuclear abnormalities Article Swipe
Daniel Angel‐Velez
,
Tine De Coster
,
Nima Azari‐Dolatabad
,
Andrea Fernández-Montoro
,
Camilla Benedetti
,
Krishna Chaitanya Pavani
,
Ann Van Soom
,
Osvaldo Bogado Pascottini
,
Katrien Smits
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-023-31268-6
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-023-31268-6
Embryo development is a dynamic process and critical stages may go unnoticed with the use of traditional morphologic assessments, especially the timing of embryonic divisions and aberrant zygotic cleavage patterns. Bovine embryo development is impaired after oocyte vitrification, but little is known about the underlying morphokinetic behavior. Here, bovine zygotes from fresh (n = 708) and vitrified oocytes (n = 182) were monitored by time-lapse imaging and the timing and nature of early blastomere divisions were modeled to find associations with blastocyst development at day 8. The predictive potential of morphokinetic parameters was analyzed by logistic regression and receiver operating characteristic curve analysis to determine optimal cut-off values. Lag-phase was highly correlated with embryo development. Remarkably, 100% of zygotes that reached the blastocyst stage showed a lag-phase. Fast first cleavage increased the chance of blastocyst development to 30% with a cut-off of 32 h and 22 min. Aberrant zygotic cleavage events, including multipolar division, unequal blastomere sizes, and membrane ruffling resulted in decreased blastocyst development. Multipolar division leads to uneven blastomeres, which was associated with anuclear and multinuclear blastomeres, indicating genome segregation errors. Moreover, we described for the first time morphokinetics of embryos derived from vitrified bovine oocytes. Vitrification severely affected blastocyst development, although lower cryoprotectant concentration in equilibration solutions seems to be less detrimental for embryo yield. Impaired development was linked to slow cleavages, lower lag-phase incidence, and increased early embryonic arrest. Typically, less than 15% of the embryos produced from vitrified oocytes reached more than eight cells. Interestingly, the rate of abnormal first cleavage events was not affected by oocyte vitrification. In conclusion, time to first cleavage, the presence of a lag-phase, and the absence of aberrant zygotic cleavage were the best predictors of bovine blastocyst development for both fresh and vitrified oocytes.
Related Topics
Concepts
Blastocyst
Blastomere
Zygote
Embryo
Vitrification
Andrology
Embryogenesis
Biology
Oocyte
Cleavage (geology)
Cell biology
Medicine
Paleontology
Fracture (geology)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-023-31268-6
- https://www.nature.com/articles/s41598-023-31268-6.pdf
- OA Status
- gold
- Cited By
- 19
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4360603524
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4360603524Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-023-31268-6Digital Object Identifier
- Title
-
Embryo morphokinetics derived from fresh and vitrified bovine oocytes predict blastocyst development and nuclear abnormalitiesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-23Full publication date if available
- Authors
-
Daniel Angel‐Velez, Tine De Coster, Nima Azari‐Dolatabad, Andrea Fernández-Montoro, Camilla Benedetti, Krishna Chaitanya Pavani, Ann Van Soom, Osvaldo Bogado Pascottini, Katrien SmitsList of authors in order
- Landing page
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https://doi.org/10.1038/s41598-023-31268-6Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41598-023-31268-6.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-023-31268-6.pdfDirect OA link when available
- Concepts
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Blastocyst, Blastomere, Zygote, Embryo, Vitrification, Andrology, Embryogenesis, Biology, Oocyte, Cleavage (geology), Cell biology, Medicine, Paleontology, Fracture (geology)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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19Total citation count in OpenAlex
- Citations by year (recent)
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2025: 10, 2024: 6, 2023: 3Per-year citation counts (last 5 years)
- References (count)
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92Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.blastomere | 74, 156 |
| abstract_inverted_index.cleavages, | 225 |
| abstract_inverted_index.correlated | 112 |
| abstract_inverted_index.especially | 20 |
| abstract_inverted_index.incidence, | 228 |
| abstract_inverted_index.indicating | 180 |
| abstract_inverted_index.lag-phase, | 274 |
| abstract_inverted_index.lag-phase. | 127 |
| abstract_inverted_index.multipolar | 153 |
| abstract_inverted_index.parameters | 92 |
| abstract_inverted_index.predictive | 88 |
| abstract_inverted_index.predictors | 285 |
| abstract_inverted_index.regression | 97 |
| abstract_inverted_index.time-lapse | 65 |
| abstract_inverted_index.underlying | 45 |
| abstract_inverted_index.Remarkably, | 116 |
| abstract_inverted_index.conclusion, | 265 |
| abstract_inverted_index.detrimental | 215 |
| abstract_inverted_index.development | 2, 33, 83, 136, 220, 289 |
| abstract_inverted_index.morphologic | 18 |
| abstract_inverted_index.segregation | 182 |
| abstract_inverted_index.traditional | 17 |
| abstract_inverted_index.assessments, | 19 |
| abstract_inverted_index.associations | 80 |
| abstract_inverted_index.blastomeres, | 171, 179 |
| abstract_inverted_index.development, | 203 |
| abstract_inverted_index.development. | 115, 165 |
| abstract_inverted_index.multinuclear | 178 |
| abstract_inverted_index.Vitrification | 199 |
| abstract_inverted_index.concentration | 207 |
| abstract_inverted_index.equilibration | 209 |
| abstract_inverted_index.morphokinetic | 46, 91 |
| abstract_inverted_index.Interestingly, | 250 |
| abstract_inverted_index.characteristic | 101 |
| abstract_inverted_index.cryoprotectant | 206 |
| abstract_inverted_index.morphokinetics | 191 |
| abstract_inverted_index.vitrification, | 38 |
| abstract_inverted_index.vitrification. | 263 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5065867330 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I32597200 |
| citation_normalized_percentile.value | 0.96934937 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |