Emerging roles of non-coding RNAs in fibroblast to myofibroblast transition and fibrotic diseases Article Swipe
Xuewu Xing
,
Scott A. Rodeo
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2024.1423045
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2024.1423045
The transition of fibroblasts to myofibroblasts (FMT) represents a pivotal process in wound healing, tissue repair, and fibrotic diseases. This intricate transformation involves dynamic changes in cellular morphology, gene expression, and extracellular matrix remodeling. While extensively studied at the molecular level, recent research has illuminated the regulatory roles of non-coding RNAs (ncRNAs) in orchestrating FMT. This review explores the emerging roles of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating this intricate process. NcRNAs interface with key signaling pathways, transcription factors, and epigenetic mechanisms to fine-tune gene expression during FMT. Their functions are critical in maintaining tissue homeostasis, and disruptions in these regulatory networks have been linked to pathological fibrosis across various tissues. Understanding the dynamic roles of ncRNAs in FMT bears therapeutic promise. Targeting specific ncRNAs holds potential to mitigate exaggerated myofibroblast activation and tissue fibrosis. However, challenges in delivery and specificity of ncRNA-based therapies remain. In summary, ncRNAs emerge as integral regulators in the symphony of FMT, orchestrating the balance between quiescent fibroblasts and activated myofibroblasts. As research advances, these ncRNAs appear to be prospects for innovative therapeutic strategies, offering hope in taming the complexities of fibrosis and restoring tissue equilibrium.
Related Topics
Concepts
Myofibroblast
microRNA
Epigenetics
Non-coding RNA
Biology
Cell biology
Extracellular matrix
Fibrosis
Transcription factor
Wound healing
Regulation of gene expression
Competing endogenous RNA
Computational biology
Bioinformatics
Long non-coding RNA
Gene
RNA
Genetics
Medicine
Pathology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2024.1423045
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1423045/pdf
- OA Status
- gold
- Cited By
- 9
- References
- 198
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400964198
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400964198Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fphar.2024.1423045Digital Object Identifier
- Title
-
Emerging roles of non-coding RNAs in fibroblast to myofibroblast transition and fibrotic diseasesWork title
- Type
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reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-07-24Full publication date if available
- Authors
-
Xuewu Xing, Scott A. RodeoList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2024.1423045Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1423045/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1423045/pdfDirect OA link when available
- Concepts
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Myofibroblast, microRNA, Epigenetics, Non-coding RNA, Biology, Cell biology, Extracellular matrix, Fibrosis, Transcription factor, Wound healing, Regulation of gene expression, Competing endogenous RNA, Computational biology, Bioinformatics, Long non-coding RNA, Gene, RNA, Genetics, Medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 9Per-year citation counts (last 5 years)
- References (count)
-
198Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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