En face OCT: Breakthroughs in understanding the pathoanatomy of retinal disease and clinical applications Article Swipe
Alessandro Feo
,
Prithvi Ramtohul
,
Andrea Govetto
,
Enrico Borrelli
,
Riccardo Sacconi
,
Giulia Corradetti
,
Giuseppe Querques
,
Mario R. Romano
,
Philip J. Rosenfeld
,
Richard F. Spaide
,
K. Bailey Freund
,
SriniVas R. Sadda
,
David Sarraf
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.preteyeres.2025.101351
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.preteyeres.2025.101351
En face optical coherence tomography (OCT) is a practical and informative imaging modality to noninvasively visualize distinct retinal and choroidal layers by providing coronal images using boundary-specific segmentation. Ongoing research with this method is generating breakthroughs in the illustration of new perspectives of retinal disease. The clinical value of en face OCT as an advanced retinal imaging tool is growing steadily and it has unveiled many new insights into the pathoanatomy of retinal disorders. Moreover, this modality can capture various en face OCT biomarkers that correspond to different cell or tissue subtypes, which were previously only identified through histological or electron microscopy methods, underscoring the significance of this technique in providing valuable pathoanatomical information. In this comprehensive review, we will systematically summarize the en face OCT findings across a broad spectrum of retinal diseases, including disorders of the vitreoretinal interface and retinal vascular system (e.g. paracentral acute middle maculopathy or PAMM and diabetic retinopathy), in addition to the en face OCT features of other conditions such as age-related macular degeneration, pachychoroid disease spectrum, myopic degeneration, uveitis and inflammatory disorders, inherited retinal dystrophies, and drug toxicity. We will discuss and highlight the unique clinical and pathoanatomical findings uncovered with en face OCT of each these diseases mentioned above.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.preteyeres.2025.101351
- OA Status
- hybrid
- Cited By
- 11
- References
- 549
- Related Works
- 10
- OpenAlex ID
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- DOI
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https://doi.org/10.1016/j.preteyeres.2025.101351Digital Object Identifier
- Title
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En face OCT: Breakthroughs in understanding the pathoanatomy of retinal disease and clinical applicationsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-05Full publication date if available
- Authors
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Alessandro Feo, Prithvi Ramtohul, Andrea Govetto, Enrico Borrelli, Riccardo Sacconi, Giulia Corradetti, Giuseppe Querques, Mario R. Romano, Philip J. Rosenfeld, Richard F. Spaide, K. Bailey Freund, SriniVas R. Sadda, David SarrafList of authors in order
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https://doi.org/10.1016/j.preteyeres.2025.101351Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.preteyeres.2025.101351Direct OA link when available
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Retinal, Face (sociological concept), Medicine, Ophthalmology, Anatomy, Optometry, Neuroscience, Psychology, Philosophy, LinguisticsTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 11Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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