Encephalitis following COVID-19 Vaccination: A Systematic Review Article Swipe
Mariam Abdelhady
,
Muhammad Ashraf Husain
,
Yousef Hawas
,
Mahmoud Abdelsalam Elazb
,
Lena Said Mansour
,
Mohamed Mohamed
,
Maya Magdy Abdelwahab
,
Ahmed Aljabali
,
Ahmed Negida
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/vaccines11030576
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/vaccines11030576
Background: Since the advent of global COVID-19 vaccination, several studies reported cases of encephalitis with its various subtypes following COVID-19 vaccinations. In this regard, we conducted a systematic review to investigate and characterize the clinical settings of these reported cases to aid in physician awareness and proper care provision. Methods: We systematically searched PubMed, Web of Science, and Scopus and manually searched Google Scholar. Studies published until October 2022 were included. Demographic data, clinical features, vaccine data, treatment lines, and outcomes were extracted. Results: A total of 65 patients from 52 studies were included. The mean age of patients was 46.82 ± 19.25 years, 36 cases (55.4%) were males. AstraZeneca was the most-reported vaccine associated with encephalitis (38.5%) followed by Pfizer (33.8%), Moderna (16.9%), and others. Moat encephalitis cases occurred after the first dose of vaccination in 41/65 (66.1%). The mean time between vaccination and symptom onset was 9.97 ± 7.16 days. Corticosteroids (86.2 %) and immunosuppressants (81.5 %) were the most used lines of treatment. The majority of affected individuals experienced a full recovery. Conclusion: Our study summarizes the current evidence of reported post-vaccination encephalitis, regarding clinical presentation, symptoms onset, management, outcomes, and comorbid conditions; however, it fails to either acknowledge the incidence of occurrence or establish a causal relationship between various COVID-19 vaccines and encephalitis.
Related Topics
Concepts
Coronavirus disease 2019 (COVID-19)
Vaccination
Virology
2019-20 coronavirus outbreak
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Encephalitis
Medicine
Pandemic
Outbreak
Virus
Disease
Pathology
Infectious disease (medical specialty)
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/vaccines11030576
- https://www.mdpi.com/2076-393X/11/3/576/pdf?version=1678075310
- OA Status
- gold
- Cited By
- 20
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4323047570
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4323047570Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/vaccines11030576Digital Object Identifier
- Title
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Encephalitis following COVID-19 Vaccination: A Systematic ReviewWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-03-02Full publication date if available
- Authors
-
Mariam Abdelhady, Muhammad Ashraf Husain, Yousef Hawas, Mahmoud Abdelsalam Elazb, Lena Said Mansour, Mohamed Mohamed, Maya Magdy Abdelwahab, Ahmed Aljabali, Ahmed NegidaList of authors in order
- Landing page
-
https://doi.org/10.3390/vaccines11030576Publisher landing page
- PDF URL
-
https://www.mdpi.com/2076-393X/11/3/576/pdf?version=1678075310Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-393X/11/3/576/pdf?version=1678075310Direct OA link when available
- Concepts
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Coronavirus disease 2019 (COVID-19), Vaccination, Virology, 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Encephalitis, Medicine, Pandemic, Outbreak, Virus, Disease, Pathology, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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20Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 11, 2023: 5Per-year citation counts (last 5 years)
- References (count)
-
38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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