End-stage heart failure in congenitally corrected transposition of the great arteries: a multicentre study Article Swipe
Alexandra C. van Dissel
,
Alexander R. Opotowsky
,
Luke J. Burchill
,
Jamil Aboulhosn
,
Jasmine Grewal
,
Adam M. Lubert
,
Petra Antonová
,
Sangeeta Shah
,
Timothy B. Cotts
,
Anitha S. John
,
W. Aaron Kay
,
Christopher DeZorzi
,
Anthony Magalski
,
Frank Han
,
David W. Baker
,
Joseph Kay
,
Elizabeth Yeung
,
Isabelle Vonder Muhll
,
Stephen Pylypchuk
,
Marissa C. Kuo
,
Jeremy Nicolarsen
,
Berardo Sarubbi
,
Flavia Fusco
,
Susan M Jameson
,
Jonathan Cramer
,
Tripti Gupta
,
Pastora Gallego
,
Clare O’Donnell
,
Jane Hannah
,
Mikael Dellborg
,
Robert M. Kauling
,
Salil Ginde
,
Eric V. Krieger
,
Fred H. Rodriguez
,
Payam Dehghani
,
Shelby Kutty
,
Joshua Wong
,
William Wilson
,
Carla P. Rodríguez-Monserrate
,
Jolien W. Roos‐Hesselink
,
David S. Celermajer
,
Paul Khairy
,
Craig S. Broberg
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/eurheartj/ehad511
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/eurheartj/ehad511
Background and Aims For patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated with progression to end-stage congestive heart failure (CHF) remain largely unclear. Methods This multicentre, retrospective cohort study included adults with ccTGA seen at a congenital heart disease centre. Clinical data from initial and most recent visits were obtained. The composite primary outcome was mechanical circulatory support, heart transplantation, or death. Results From 558 patients (48% female, age at first visit 36 ± 14.2 years, median follow-up 8.7 years), the event rate of the primary outcome was 15.4 per 1000 person-years (11 mechanical circulatory support implantations, 12 transplantations, and 52 deaths). Patients experiencing the primary outcome were older and more likely to have a history of atrial arrhythmia. The primary outcome was highest in those with both moderate/severe right ventricular (RV) dysfunction and tricuspid regurgitation (n = 110, 31 events) and uncommon in those with mild/less RV dysfunction and tricuspid regurgitation (n = 181, 13 events, P < .001). Outcomes were not different based on anatomic complexity and history of tricuspid valve surgery or of subpulmonic obstruction. New CHF admission or ventricular arrhythmia was associated with the primary outcome. Individuals who underwent childhood surgery had more adverse outcomes than age- and sex-matched controls. Multivariable Cox regression analysis identified older age, prior CHF admission, and severe RV dysfunction as independent predictors for the primary outcome. Conclusions Patients with ccTGA have variable deterioration to end-stage heart failure or death over time, commonly between their fifth and sixth decades. Predictors include arrhythmic and CHF events and severe RV dysfunction but not anatomy or need for tricuspid valve surgery.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/eurheartj/ehad511
- https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehad511/51143186/ehad511.pdf
- OA Status
- bronze
- Cited By
- 33
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385968367
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385968367Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/eurheartj/ehad511Digital Object Identifier
- Title
-
End-stage heart failure in congenitally corrected transposition of the great arteries: a multicentre studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-08-18Full publication date if available
- Authors
-
Alexandra C. van Dissel, Alexander R. Opotowsky, Luke J. Burchill, Jamil Aboulhosn, Jasmine Grewal, Adam M. Lubert, Petra Antonová, Sangeeta Shah, Timothy B. Cotts, Anitha S. John, W. Aaron Kay, Christopher DeZorzi, Anthony Magalski, Frank Han, David W. Baker, Joseph Kay, Elizabeth Yeung, Isabelle Vonder Muhll, Stephen Pylypchuk, Marissa C. Kuo, Jeremy Nicolarsen, Berardo Sarubbi, Flavia Fusco, Susan M Jameson, Jonathan Cramer, Tripti Gupta, Pastora Gallego, Clare O’Donnell, Jane Hannah, Mikael Dellborg, Robert M. Kauling, Salil Ginde, Eric V. Krieger, Fred H. Rodriguez, Payam Dehghani, Shelby Kutty, Joshua Wong, William Wilson, Carla P. Rodríguez-Monserrate, Jolien W. Roos‐Hesselink, David S. Celermajer, Paul Khairy, Craig S. BrobergList of authors in order
- Landing page
-
https://doi.org/10.1093/eurheartj/ehad511Publisher landing page
- PDF URL
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https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehad511/51143186/ehad511.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehad511/51143186/ehad511.pdfDirect OA link when available
- Concepts
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Medicine, Great arteries, Heart failure, Cardiology, Internal medicine, Transposition (logic), Stage (stratigraphy), Heart disease, Biology, Paleontology, Linguistics, PhilosophyTop concepts (fields/topics) attached by OpenAlex
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33Total citation count in OpenAlex
- Citations by year (recent)
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2025: 14, 2024: 17, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.included | 34 |
| abstract_inverted_index.outcome. | 194, 229 |
| abstract_inverted_index.outcomes | 203 |
| abstract_inverted_index.patients | 5, 70 |
| abstract_inverted_index.support, | 62 |
| abstract_inverted_index.surgery. | 270 |
| abstract_inverted_index.unclear. | 27 |
| abstract_inverted_index.uncommon | 147 |
| abstract_inverted_index.variable | 235 |
| abstract_inverted_index.admission | 185 |
| abstract_inverted_index.childhood | 198 |
| abstract_inverted_index.composite | 56 |
| abstract_inverted_index.controls. | 208 |
| abstract_inverted_index.corrected | 8 |
| abstract_inverted_index.different | 168 |
| abstract_inverted_index.end-stage | 20, 238 |
| abstract_inverted_index.follow-up | 82 |
| abstract_inverted_index.mild/less | 151 |
| abstract_inverted_index.obtained. | 54 |
| abstract_inverted_index.tricuspid | 139, 155, 176, 268 |
| abstract_inverted_index.underwent | 197 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Predictors | 252 |
| abstract_inverted_index.admission, | 218 |
| abstract_inverted_index.arrhythmia | 188 |
| abstract_inverted_index.arrhythmic | 254 |
| abstract_inverted_index.associated | 16, 190 |
| abstract_inverted_index.complexity | 172 |
| abstract_inverted_index.congenital | 41 |
| abstract_inverted_index.congestive | 21 |
| abstract_inverted_index.identified | 213 |
| abstract_inverted_index.mechanical | 60, 98 |
| abstract_inverted_index.predictors | 225 |
| abstract_inverted_index.regression | 211 |
| abstract_inverted_index.Conclusions | 230 |
| abstract_inverted_index.Individuals | 195 |
| abstract_inverted_index.arrhythmia. | 123 |
| abstract_inverted_index.circulatory | 61, 99 |
| abstract_inverted_index.dysfunction | 137, 153, 222, 261 |
| abstract_inverted_index.independent | 224 |
| abstract_inverted_index.progression | 18 |
| abstract_inverted_index.sex-matched | 207 |
| abstract_inverted_index.subpulmonic | 181 |
| abstract_inverted_index.ventricular | 135, 187 |
| abstract_inverted_index.congenitally | 7 |
| abstract_inverted_index.experiencing | 108 |
| abstract_inverted_index.multicentre, | 30 |
| abstract_inverted_index.obstruction. | 182 |
| abstract_inverted_index.person-years | 96 |
| abstract_inverted_index.Multivariable | 209 |
| abstract_inverted_index.deterioration | 236 |
| abstract_inverted_index.regurgitation | 140, 156 |
| abstract_inverted_index.retrospective | 31 |
| abstract_inverted_index.transposition | 9 |
| abstract_inverted_index.implantations, | 101 |
| abstract_inverted_index.moderate/severe | 133 |
| abstract_inverted_index.transplantation, | 64 |
| abstract_inverted_index.transplantations, | 103 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 9 |
| institutions_distinct_count | 43 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.98374981 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |