Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex Article Swipe
Chiaki Itami
,
Naofumi Uesaka
,
Jui-Yen Huang
,
Hui‐Chen Lu
,
Kenji Sakimura
,
Masanobu Kano
,
Fumitaka Kimura
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2122700119
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2122700119
Columnar structure is one of the most fundamental morphological features of the cerebral cortex and is thought to be the basis of information processing in higher animals. Yet, how such a topographically precise structure is formed is largely unknown. Formation of columnar projection of layer 4 (L4) axons is preceded by thalamocortical formation, in which type 1 cannabinoid receptors (CB1R) play an important role in shaping barrel-specific targeted projection by operating spike timing-dependent plasticity during development (Itami et al. , J. Neurosci. 36, 7039–7054 [2016]; Kimura & Itami, J. Neurosci. 39, 3784–3791 [2019]). Right after the formation of thalamocortical projections, CB1Rs start to function at L4 axon terminals (Itami & Kimura, J. Neurosci. 32, 15000–15011 [2012]), which coincides with the timing of columnar shaping of L4 axons. Here, we show that the endocannabinoid 2-arachidonoylglycerol (2-AG) plays a crucial role in columnar shaping. We found that L4 axon projections were less organized until P12 and then became columnar after CB1Rs became functional. By contrast, the columnar organization of L4 axons was collapsed in mice genetically lacking diacylglycerol lipase α, the major enzyme for 2-AG synthesis. Intraperitoneally administered CB1R agonists shortened axon length, whereas knockout of CB1R in L4 neurons impaired columnar projection of their axons. Our results suggest that endocannabinoid signaling is crucial for shaping columnar axonal projection in the cerebral cortex.
Related Topics
Concepts
Diacylglycerol lipase
Neuroscience
Axon
Endocannabinoid system
Biology
Axoplasmic transport
Cannabinoid receptor
Anatomy
Monoacylglycerol lipase
Receptor
Biochemistry
Agonist
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2122700119
- OA Status
- green
- Cited By
- 8
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4294844616
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4294844616Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.2122700119Digital Object Identifier
- Title
-
Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortexWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-06Full publication date if available
- Authors
-
Chiaki Itami, Naofumi Uesaka, Jui-Yen Huang, Hui‐Chen Lu, Kenji Sakimura, Masanobu Kano, Fumitaka KimuraList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.2122700119Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/9477236Direct OA link when available
- Concepts
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Diacylglycerol lipase, Neuroscience, Axon, Endocannabinoid system, Biology, Axoplasmic transport, Cannabinoid receptor, Anatomy, Monoacylglycerol lipase, Receptor, Biochemistry, AgonistTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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37Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.formed | 35 |
| abstract_inverted_index.higher | 25 |
| abstract_inverted_index.lipase | 176 |
| abstract_inverted_index.timing | 120 |
| abstract_inverted_index.Kimura, | 110 |
| abstract_inverted_index.[2016]; | 84 |
| abstract_inverted_index.cortex. | 220 |
| abstract_inverted_index.crucial | 137, 211 |
| abstract_inverted_index.lacking | 174 |
| abstract_inverted_index.largely | 37 |
| abstract_inverted_index.length, | 190 |
| abstract_inverted_index.neurons | 197 |
| abstract_inverted_index.precise | 32 |
| abstract_inverted_index.results | 205 |
| abstract_inverted_index.shaping | 65, 123, 213 |
| abstract_inverted_index.suggest | 206 |
| abstract_inverted_index.thought | 16 |
| abstract_inverted_index.whereas | 191 |
| abstract_inverted_index.Columnar | 0 |
| abstract_inverted_index.[2012]), | 115 |
| abstract_inverted_index.[2019]). | 92 |
| abstract_inverted_index.agonists | 187 |
| abstract_inverted_index.animals. | 26 |
| abstract_inverted_index.cerebral | 12, 219 |
| abstract_inverted_index.columnar | 41, 122, 140, 156, 164, 199, 214 |
| abstract_inverted_index.features | 9 |
| abstract_inverted_index.function | 103 |
| abstract_inverted_index.impaired | 198 |
| abstract_inverted_index.knockout | 192 |
| abstract_inverted_index.preceded | 49 |
| abstract_inverted_index.shaping. | 141 |
| abstract_inverted_index.targeted | 67 |
| abstract_inverted_index.unknown. | 38 |
| abstract_inverted_index.Formation | 39 |
| abstract_inverted_index.Neurosci. | 81, 89, 112 |
| abstract_inverted_index.coincides | 117 |
| abstract_inverted_index.collapsed | 170 |
| abstract_inverted_index.contrast, | 162 |
| abstract_inverted_index.formation | 96 |
| abstract_inverted_index.important | 62 |
| abstract_inverted_index.operating | 70 |
| abstract_inverted_index.organized | 150 |
| abstract_inverted_index.receptors | 58 |
| abstract_inverted_index.shortened | 188 |
| abstract_inverted_index.signaling | 209 |
| abstract_inverted_index.structure | 1, 33 |
| abstract_inverted_index.terminals | 107 |
| abstract_inverted_index.formation, | 52 |
| abstract_inverted_index.plasticity | 73 |
| abstract_inverted_index.processing | 23 |
| abstract_inverted_index.projection | 42, 68, 200, 216 |
| abstract_inverted_index.synthesis. | 183 |
| abstract_inverted_index.3784–3791 | 91 |
| abstract_inverted_index.7039–7054 | 83 |
| abstract_inverted_index.cannabinoid | 57 |
| abstract_inverted_index.development | 75 |
| abstract_inverted_index.functional. | 160 |
| abstract_inverted_index.fundamental | 7 |
| abstract_inverted_index.genetically | 173 |
| abstract_inverted_index.information | 22 |
| abstract_inverted_index.projections | 147 |
| abstract_inverted_index.administered | 185 |
| abstract_inverted_index.organization | 165 |
| abstract_inverted_index.projections, | 99 |
| abstract_inverted_index.15000–15011 | 114 |
| abstract_inverted_index.morphological | 8 |
| abstract_inverted_index.diacylglycerol | 175 |
| abstract_inverted_index.barrel-specific | 66 |
| abstract_inverted_index.endocannabinoid | 132, 208 |
| abstract_inverted_index.thalamocortical | 51, 98 |
| abstract_inverted_index.topographically | 31 |
| abstract_inverted_index.timing-dependent | 72 |
| abstract_inverted_index.Intraperitoneally | 184 |
| abstract_inverted_index.2-arachidonoylglycerol | 133 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.70513221 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |