Endocrine-enriched stem cell-derived islets improve long-term safety in vivo Article Swipe
Eunike Sawitning Ayu Setyono
,
N Rogers
,
Katharina Scheibner
,
Silvia Schirge
,
H. Reich
,
Michael Sterr
,
Timucin Öztürk
,
Sören Franzenburg
,
Väinö Lithovius
,
Heiko Lickert
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.22.671768
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.22.671768
Fully differentiated stem cell-derived islets (SC-islets) are proven to normalise blood glucose in type 1 diabetic patients. However, the presence of off-target cell types and the immature SC-islet function upon transplantation remain unresolved problems. Here, we established sorting strategies to generate SC-islets with defined glucagon-producing SC-α- and insulin-producing β-cell ratios and assessed their safety and efficacy in vitro and in vivo . Engineering SC-islets is beneficial to the insulin response in vitro , which does not translate to improved glycaemic regulation in vivo . Importantly, hormone-producing endocrine cell enrichment and thus off-target cell type depletion eliminated the risk for unwanted outgrowth in vivo . Single cell analysis defined off-target cells in vitro and in vivo and identified marker genes to assess SC-islet quality and define safety release criteria before graft transplantation. This study highlights the importance of determining the SC-islet composition and establishing rigorous quality controls to ensure long-term safety for β-cell replacement therapy.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.08.22.671768
- https://www.biorxiv.org/content/biorxiv/early/2025/08/23/2025.08.22.671768.full.pdf
- OA Status
- green
- References
- 122
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413446996
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413446996Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.08.22.671768Digital Object Identifier
- Title
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Endocrine-enriched stem cell-derived islets improve long-term safety in vivoWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-23Full publication date if available
- Authors
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Eunike Sawitning Ayu Setyono, N Rogers, Katharina Scheibner, Silvia Schirge, H. Reich, Michael Sterr, Timucin Öztürk, Sören Franzenburg, Väinö Lithovius, Heiko LickertList of authors in order
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https://doi.org/10.1101/2025.08.22.671768Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2025/08/23/2025.08.22.671768.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2025/08/23/2025.08.22.671768.full.pdfDirect OA link when available
- Concepts
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Islet, In vivo, Transplantation, Stem cell, Glucagon, Biology, Cell, Cell sorting, Insulin, Cell biology, Internal medicine, Endocrinology, Medicine, Biochemistry, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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122Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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