Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by curbing luminal transport Article Swipe
Tasuku Konno
,
Pierre Parutto
,
David M. Bailey
,
Valentina Davì
,
Cécile C. Crapart
,
Mosab Ali Awadelkareem
,
Colin Hockings
,
Aidan I. Brown
,
Katherine M. Xiang
,
Anamika Agrawal
,
Joseph E. Chambers
,
Molly J Vander Werp
,
Katherine Koning
,
Emmanouil Metzakopian
,
Laura M. Westrate
,
Elena F. Koslover
,
Edward Avezov
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.05.10.441946
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.05.10.441946
Cell and tissue functions rely on an elaborate intracellular transport system responsible for distributing bioactive molecules with high spatiotemporal accuracy. The tubular network of the Endoplasmic Reticulum (ER) constitutes a system for the delivery of luminal solutes it stores, including Ca 2+ , across the cell periphery. The physical nature and factors underlying the ER’s functioning as a fluidics system are unclear. Using an improved ER transport visualisation methodology combined with optogenetic Ca 2+ dynamics imaging, we observed that ER luminal transport is modulated by natural ER tubule narrowing and dilation, directly proportional to the amount of an ER membrane morphogen, Reticulon 4 (RTN4). Consequently, the ER morphoregulatory effect of RTN4 defines ER’s capacity for peripheral Ca 2+ delivery and thus controls axonogenesis. Excess RTN4 limited ER luminal transport, Ca 2+ release and iPSC-derived cortical neurons’ axonal extension, while RTN4 elimination reversed the effects. Summary Intracellular transport through the lumen of the ER network is modulated through narrowing/dilation of ER tubules by a membrane morphogen – RTN4, a process controlling axonogenesis by limiting the delivery of ER-stored Ca 2+ .
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.05.10.441946
- https://www.biorxiv.org/content/biorxiv/early/2021/05/10/2021.05.10.441946.full.pdf
- OA Status
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- Cited By
- 8
- References
- 38
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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https://doi.org/10.1101/2021.05.10.441946Digital Object Identifier
- Title
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Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by curbing luminal transportWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-05-10Full publication date if available
- Authors
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Tasuku Konno, Pierre Parutto, David M. Bailey, Valentina Davì, Cécile C. Crapart, Mosab Ali Awadelkareem, Colin Hockings, Aidan I. Brown, Katherine M. Xiang, Anamika Agrawal, Joseph E. Chambers, Molly J Vander Werp, Katherine Koning, Emmanouil Metzakopian, Laura M. Westrate, Elena F. Koslover, Edward AvezovList of authors in order
- Landing page
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https://doi.org/10.1101/2021.05.10.441946Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2021/05/10/2021.05.10.441946.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2021/05/10/2021.05.10.441946.full.pdfDirect OA link when available
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Endoplasmic reticulum, Cell biology, Regeneration (biology), BiologyTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
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2024: 2, 2023: 4, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
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38Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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