Endoplasmic reticulum patterns insect cuticle nanostructure Article Swipe
Sachi Inagaki
,
Housei Wada
,
Takeshi Itabashi
,
Yuki Itakura
,
Reiko Nakagawa
,
Lin Chen
,
Kazuyoshi Murata
,
Atsuko H. Iwane
,
Shigeo Hayashi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.20.608717
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.20.608717
Insect cuticles with nano-level structures exhibit functional surface properties such as structural color and superhydrophobicity. Despite the enormous influence the cuticle has had on biomimetic industrial applications, molecular and cellular mechanisms of cuticular extracellular matrix (ECM) assembly into nanoscale structures remain poorly understood in insects and other taxa. Ghiradella (1989) described how a crystallin-like lattice of endoplasmic reticulum (ER) prefigures the patterning of the porous cuticle of the butterfly wing scale with structural color 1 . Building on that insight, we show that the nanopore structure of the olfactory (olf) organs, which serve as molecular filters in Drosophila, is built through a novel process in which ER material is trafficked to the plasma membrane mediated by the autophagy pathway. The process is controlled by the insect-specific protein Gore-tex/Osiris23 (Gox) 2 , which is localized to the tubular ER of olf hair cells. Gox recruits Ref(2)P, the fly counterpart of mammalian p62/SQSTM1 3 , to initiate ER scission. The excised ER fragments are processed by autophagy to gain access to the plasma membrane and trigger membrane invagination, which plays a role in remodeling the cuticular envelope layer to the nanopore formation. This repurposing of the ER phagy for machinery to support the fabrication of nanoscale ECM by the Gox protein sheds light on the nanopatterning of insect cuticles and their genetic control.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.08.20.608717
- https://www.biorxiv.org/content/biorxiv/early/2024/08/21/2024.08.20.608717.full.pdf
- OA Status
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- Cited By
- 1
- References
- 36
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401845291Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.08.20.608717Digital Object Identifier
- Title
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Endoplasmic reticulum patterns insect cuticle nanostructureWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-21Full publication date if available
- Authors
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Sachi Inagaki, Housei Wada, Takeshi Itabashi, Yuki Itakura, Reiko Nakagawa, Lin Chen, Kazuyoshi Murata, Atsuko H. Iwane, Shigeo HayashiList of authors in order
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https://doi.org/10.1101/2024.08.20.608717Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2024/08/21/2024.08.20.608717.full.pdfDirect link to full text PDF
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2024/08/21/2024.08.20.608717.full.pdfDirect OA link when available
- Concepts
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Endoplasmic reticulum, Cell biology, Cuticle (hair), Insect, Arthropod cuticle, Extracellular matrix, Biophysics, Nanotechnology, Biology, Chemistry, Materials science, Anatomy, EcologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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