Endospanin 1 Determines the Balance of Leptin-Regulated Hypothalamic Functions Article Swipe
Clara Roujeau
,
Ralf Jockers
,
Julie Dam
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1159/000494557
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1159/000494557
Endospanin 1 (Endo1), a protein encoded in humans by the same gene than the leptin receptor (ObR), and increased by diet-induced obesity, is an important regulator of ObR trafficking and cell surface exposure, determining leptin signaling strength. Defective intracellular trafficking of the leptin receptor to the neuronal plasma membrane has been proposed as a mechanism underlying the development of leptin resistance observed in human obesity. More recently, Endo1 has emerged as a mediator of “selective leptin resistance.” The underlying mechanisms of the latter are not completely understood, but the possibility of differential activation of leptin signaling pathways was suggested among others. In this respect, the expression level of Endo1 is crucial for the appropriate balance between different leptin signaling pathways and leptin functions in the hypothalamus and is likely participating in selective leptin resistance for the control of energy and glucose homeostasis.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1159/000494557
- https://www.karger.com/Article/Pdf/494557
- OA Status
- bronze
- Cited By
- 12
- References
- 87
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2897074782
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2897074782Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1159/000494557Digital Object Identifier
- Title
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Endospanin 1 Determines the Balance of Leptin-Regulated Hypothalamic FunctionsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-10-16Full publication date if available
- Authors
-
Clara Roujeau, Ralf Jockers, Julie DamList of authors in order
- Landing page
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https://doi.org/10.1159/000494557Publisher landing page
- PDF URL
-
https://www.karger.com/Article/Pdf/494557Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.karger.com/Article/Pdf/494557Direct OA link when available
- Concepts
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Leptin, Leptin receptor, Internal medicine, Endocrinology, Hypothalamus, Mediator, Energy homeostasis, Regulator, Receptor, Biology, Homeostasis, Signal transduction, Obesity, Cell biology, Gene, Medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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12Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 1, 2022: 3, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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87Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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