Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury Article Swipe
Shataakshi Dube
,
Tejasvi Matam
,
Jessica Yen
,
Henry Mang
,
Pierre C. Dagher
,
Takashi Hato
,
Timothy A. Sutton
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1155/2017/4609502
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1155/2017/4609502
STAT3 is a transcriptional regulator that plays an important role in coordinating inflammation and immunity. In addition, there is a growing appreciation of the role STAT3 signaling plays in response to organ injury following diverse insults. Acute kidney injury (AKI) from ischemia-reperfusion injury is a common clinical entity with devastating consequences, and the recognition that endothelial alterations contribute to kidney dysfunction in this setting is of growing interest. Consequently, we used a mouse with a genetic deletion of Stat3 restricted to the endothelium to examine the role of STAT3 signaling in the pathophysiology of ischemic AKI. In a mouse model of ischemic AKI, the loss of endothelial STAT3 signaling significantly exacerbated kidney dysfunction, morphologic injury, and proximal tubular oxidative stress. The increased severity of ischemic AKI was associated with more robust endothelial-leukocyte adhesion and increased tissue accumulation of F4/80 + macrophages. Moreover, important proximal tubular adaptive mechanisms to injury were diminished in association with decreased tissue mRNA levels of the epithelial cell survival cytokine IL-22. In aggregate, these findings suggest that the endothelial STAT3 signaling plays an important role in limiting kidney dysfunction in ischemic AKI and that selective pharmacologic activation of endothelial STAT3 signaling could serve as a potential therapeutic target.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2017/4609502
- http://downloads.hindawi.com/journals/jir/2017/4609502.pdf
- OA Status
- gold
- Cited By
- 30
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2765358245
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2765358245Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2017/4609502Digital Object Identifier
- Title
-
Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney InjuryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-01-01Full publication date if available
- Authors
-
Shataakshi Dube, Tejasvi Matam, Jessica Yen, Henry Mang, Pierre C. Dagher, Takashi Hato, Timothy A. SuttonList of authors in order
- Landing page
-
https://doi.org/10.1155/2017/4609502Publisher landing page
- PDF URL
-
https://downloads.hindawi.com/journals/jir/2017/4609502.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://downloads.hindawi.com/journals/jir/2017/4609502.pdfDirect OA link when available
- Concepts
-
Acute kidney injury, Endothelial dysfunction, Ischemia, Medicine, Inflammation, Endothelium, Kidney, STAT3, Reperfusion injury, Endothelial stem cell, Oxidative stress, Signal transduction, Immunology, Cancer research, Biology, Internal medicine, Cell biology, Biochemistry, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 2, 2023: 3, 2022: 7, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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