Engineered AAV13 Variants with Enhanced Transduction and Confined Spread Article Swipe
Nengsong Luo
,
Yuxiang Cai
,
Zengpeng Han
,
Xiao-Kai Sui
,
Wen-Jia Yuan
,
Zilian Zhang
,
Hao-Dong Guo
,
Jie Wang
,
Kunzhang Lin
,
Fuqiang Xu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.24272/j.issn.2095-8137.2023.355
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.24272/j.issn.2095-8137.2023.355
Precise targeting of specific regions within the central nervous system (CNS) is crucial for both scientific research and gene therapy in the context of brain diseases. Adeno-associated virus 13 (AAV13) is known for its restricted diffusion range within the CNS, making it an ideal choice for precise labeling and administration within small brain regions. However, AAV13 mediates relatively low expression of target genes. Here, we introduced specifically engineered modifications to the AAV13 capsid protein to enhance its transduction efficiency. We first constructed AAV13-YF by mutating tyrosine to phenylalanine on the surface of the AAV13 capsid. We then inserted the 7m8 peptide, known to enhance cell transduction, into positions 587/588 and 585/586 of the AAV13 capsid, resulting in two distinct variants named AAV13-587-7m8 and AAV13-585-7m8, respectively. We found that AAV13-YF exhibited superior in vitro infectivity in HEK293T cells compared to AAV13, while AAV13-587-7m8 and AAV13-585-7m8 showed enhanced CNS infection capabilities in C57BL/6 mice, with AAV13-587-7m8 infection retaining a limited spread range. These modified AAV13 variants hold promising potential for applications in gene therapy and neuroscience research.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.24272/j.issn.2095-8137.2023.355
- OA Status
- diamond
- Cited By
- 3
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393021606
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393021606Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.24272/j.issn.2095-8137.2023.355Digital Object Identifier
- Title
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Engineered AAV13 Variants with Enhanced Transduction and Confined SpreadWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-01-01Full publication date if available
- Authors
-
Nengsong Luo, Yuxiang Cai, Zengpeng Han, Xiao-Kai Sui, Wen-Jia Yuan, Zilian Zhang, Hao-Dong Guo, Jie Wang, Kunzhang Lin, Fuqiang XuList of authors in order
- Landing page
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https://doi.org/10.24272/j.issn.2095-8137.2023.355Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.24272/j.issn.2095-8137.2023.355Direct OA link when available
- Concepts
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Transduction (biophysics), Capsid, HEK 293 cells, Context (archaeology), Biology, Gene, Cell biology, Computational biology, Genetics, Biophysics, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 1Per-year citation counts (last 5 years)
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27Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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