Engineered MS2 Virus Capsids for Cellular Display of Peptide Antigens Article Swipe
Hannah S. Martin
,
Paul Huang
,
Immanuel Leifer
,
Preeta Pratakshya
,
Matthew B. Francis
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.19.671134
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.19.671134
Our ability to respond to emerging pandemics and pathogen resistance relies critically on our ability to build vaccines quickly and efficiently. In this report we used an efficient enzymatic oxidative coupling reaction to create a viral capsid-based vaccine platform that is modular and quickly adaptable for many different pathogens. Tyrosinase-mediated oxidative coupling was used to conjugate C-terminal tyrosine residues on peptide antigens to cysteine residues installed inside MS2 viral capsids. This strategy is particularly promising because the capsids protect the internally conjugated peptides from protease degradation before they are delivered into cells. The vaccine constructs were tested for MHC presentation followed by T-cell activation. Mutants of the MS2 capsid itself activated DC2.4 cells, serving as an adjuvant to help induce the immune response to delivered antigens. The MS2-peptide constructs were shown to be stable in serum, activate DC2.4 cells, and lead to MHC-presentation of peptide antigens with subsequent activation of antigen-specific T-cell hybridomas. Taken together, these results demonstrate effective activation of the adaptive immune system in vitro . This synthetic platform can be used to build new vaccines for many different diseases for which immunodominant peptide antigens are known because the antigens can be quickly interchanged while the MS2 scaffold remains the same. Additionally, this platform allows for multiple peptide antigens to be delivered simultaneously in each capsid, which could provide enhanced immunity against resistant strains and be useful for cancer vaccine development.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.08.19.671134
- https://www.biorxiv.org/content/biorxiv/early/2025/08/19/2025.08.19.671134.full.pdf
- OA Status
- green
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413365624
All OpenAlex metadata
Raw OpenAlex JSON
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https://doi.org/10.1101/2025.08.19.671134Digital Object Identifier
- Title
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Engineered MS2 Virus Capsids for Cellular Display of Peptide AntigensWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-19Full publication date if available
- Authors
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Hannah S. Martin, Paul Huang, Immanuel Leifer, Preeta Pratakshya, Matthew B. FrancisList of authors in order
- Landing page
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https://doi.org/10.1101/2025.08.19.671134Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2025/08/19/2025.08.19.671134.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2025/08/19/2025.08.19.671134.full.pdfDirect OA link when available
- Concepts
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Capsid, Peptide, Virology, Virus, Antigen, Cell biology, Biology, Immunology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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33Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.while | 197 |
| abstract_inverted_index.T-cell | 103, 152 |
| abstract_inverted_index.allows | 207 |
| abstract_inverted_index.before | 87 |
| abstract_inverted_index.cancer | 231 |
| abstract_inverted_index.capsid | 109 |
| abstract_inverted_index.cells, | 113, 139 |
| abstract_inverted_index.cells. | 92 |
| abstract_inverted_index.create | 34 |
| abstract_inverted_index.immune | 122, 164 |
| abstract_inverted_index.induce | 120 |
| abstract_inverted_index.inside | 67 |
| abstract_inverted_index.itself | 110 |
| abstract_inverted_index.relies | 11 |
| abstract_inverted_index.report | 24 |
| abstract_inverted_index.serum, | 136 |
| abstract_inverted_index.stable | 134 |
| abstract_inverted_index.system | 165 |
| abstract_inverted_index.tested | 97 |
| abstract_inverted_index.useful | 229 |
| abstract_inverted_index.Mutants | 105 |
| abstract_inverted_index.ability | 2, 15 |
| abstract_inverted_index.against | 224 |
| abstract_inverted_index.because | 76, 190 |
| abstract_inverted_index.capsid, | 218 |
| abstract_inverted_index.capsids | 78 |
| abstract_inverted_index.modular | 42 |
| abstract_inverted_index.peptide | 61, 145, 186, 210 |
| abstract_inverted_index.protect | 79 |
| abstract_inverted_index.provide | 221 |
| abstract_inverted_index.quickly | 19, 44, 195 |
| abstract_inverted_index.remains | 201 |
| abstract_inverted_index.respond | 4 |
| abstract_inverted_index.results | 157 |
| abstract_inverted_index.serving | 114 |
| abstract_inverted_index.strains | 226 |
| abstract_inverted_index.vaccine | 38, 94, 232 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.activate | 137 |
| abstract_inverted_index.adaptive | 163 |
| abstract_inverted_index.adjuvant | 117 |
| abstract_inverted_index.antigens | 62, 146, 187, 192, 211 |
| abstract_inverted_index.capsids. | 70 |
| abstract_inverted_index.coupling | 31, 52 |
| abstract_inverted_index.cysteine | 64 |
| abstract_inverted_index.diseases | 182 |
| abstract_inverted_index.emerging | 6 |
| abstract_inverted_index.enhanced | 222 |
| abstract_inverted_index.followed | 101 |
| abstract_inverted_index.immunity | 223 |
| abstract_inverted_index.multiple | 209 |
| abstract_inverted_index.pathogen | 9 |
| abstract_inverted_index.peptides | 83 |
| abstract_inverted_index.platform | 39, 171, 206 |
| abstract_inverted_index.protease | 85 |
| abstract_inverted_index.reaction | 32 |
| abstract_inverted_index.residues | 59, 65 |
| abstract_inverted_index.response | 123 |
| abstract_inverted_index.scaffold | 200 |
| abstract_inverted_index.strategy | 72 |
| abstract_inverted_index.tyrosine | 58 |
| abstract_inverted_index.vaccines | 18, 178 |
| abstract_inverted_index.activated | 111 |
| abstract_inverted_index.adaptable | 45 |
| abstract_inverted_index.antigens. | 126 |
| abstract_inverted_index.conjugate | 56 |
| abstract_inverted_index.delivered | 90, 125, 214 |
| abstract_inverted_index.different | 48, 181 |
| abstract_inverted_index.effective | 159 |
| abstract_inverted_index.efficient | 28 |
| abstract_inverted_index.enzymatic | 29 |
| abstract_inverted_index.installed | 66 |
| abstract_inverted_index.oxidative | 30, 51 |
| abstract_inverted_index.pandemics | 7 |
| abstract_inverted_index.promising | 75 |
| abstract_inverted_index.resistant | 225 |
| abstract_inverted_index.synthetic | 170 |
| abstract_inverted_index.together, | 155 |
| abstract_inverted_index.C-terminal | 57 |
| abstract_inverted_index.activation | 149, 160 |
| abstract_inverted_index.conjugated | 82 |
| abstract_inverted_index.constructs | 95, 129 |
| abstract_inverted_index.critically | 12 |
| abstract_inverted_index.internally | 81 |
| abstract_inverted_index.pathogens. | 49 |
| abstract_inverted_index.resistance | 10 |
| abstract_inverted_index.subsequent | 148 |
| abstract_inverted_index.MS2-peptide | 128 |
| abstract_inverted_index.activation. | 104 |
| abstract_inverted_index.degradation | 86 |
| abstract_inverted_index.demonstrate | 158 |
| abstract_inverted_index.hybridomas. | 153 |
| abstract_inverted_index.capsid-based | 37 |
| abstract_inverted_index.development. | 233 |
| abstract_inverted_index.efficiently. | 21 |
| abstract_inverted_index.interchanged | 196 |
| abstract_inverted_index.particularly | 74 |
| abstract_inverted_index.presentation | 100 |
| abstract_inverted_index.Additionally, | 204 |
| abstract_inverted_index.immunodominant | 185 |
| abstract_inverted_index.simultaneously | 215 |
| abstract_inverted_index.MHC-presentation | 143 |
| abstract_inverted_index.antigen-specific | 151 |
| abstract_inverted_index.Tyrosinase-mediated | 50 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5027760459 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I95457486 |
| citation_normalized_percentile.value | 0.33904485 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |