Engineering of NEMO as calcium indicators with large dynamics and high sensitivity Article Swipe
Jia Li
,
Ziwei Shang
,
Jiahui Chen
,
Wenjia Gu
,
Li Yao
,
Xin Yang
,
Xiaowen Sun
,
Liuqing Wang
,
Tianlu Wang
,
Siyao Liu
,
Jiajing Li
,
Tingting Hou
,
Dajun Xing
,
Donald L. Gill
,
Jiejie Li
,
Shi‐Qiang Wang
,
Lijuan Hou
,
Yubin Zhou
,
Ai‐Hui Tang
,
Xiaohui Zhang
,
Youjun Wang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41592-023-01852-9
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41592-023-01852-9
Genetically encoded calcium indicators (GECIs) are indispensable tools for real-time monitoring of intracellular calcium signals and cellular activities in living organisms. Current GECIs face the challenge of suboptimal peak signal-to-baseline ratio (SBR) with limited resolution for reporting subtle calcium transients. We report herein the development of a suite of calcium sensors, designated NEMO, with fast kinetics and wide dynamic ranges (>100-fold). NEMO indicators report Ca 2+ transients with peak SBRs around 20-fold larger than the top-of-the-range GCaMP6 series. NEMO sensors further enable the quantification of absolution calcium concentration with ratiometric or photochromic imaging. Compared with GCaMP6s, NEMOs could detect single action potentials in neurons with a peak SBR two times higher and a median peak SBR four times larger in vivo, thereby outperforming most existing state-of-the-art GECIs. Given their high sensitivity and resolution to report intracellular Ca 2+ signals, NEMO sensors may find broad applications in monitoring neuronal activities and other Ca 2+ -modulated physiological processes in both mammals and plants.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41592-023-01852-9
- https://www.nature.com/articles/s41592-023-01852-9.pdf
- OA Status
- hybrid
- Cited By
- 49
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4366603018
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4366603018Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41592-023-01852-9Digital Object Identifier
- Title
-
Engineering of NEMO as calcium indicators with large dynamics and high sensitivityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-20Full publication date if available
- Authors
-
Jia Li, Ziwei Shang, Jiahui Chen, Wenjia Gu, Li Yao, Xin Yang, Xiaowen Sun, Liuqing Wang, Tianlu Wang, Siyao Liu, Jiajing Li, Tingting Hou, Dajun Xing, Donald L. Gill, Jiejie Li, Shi‐Qiang Wang, Lijuan Hou, Yubin Zhou, Ai‐Hui Tang, Xiaohui Zhang, Youjun WangList of authors in order
- Landing page
-
https://doi.org/10.1038/s41592-023-01852-9Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41592-023-01852-9.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41592-023-01852-9.pdfDirect OA link when available
- Concepts
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Calcium, Calcium in biology, Calcium imaging, Biophysics, Chemistry, Temporal resolution, Intracellular, Calcium signaling, Biology, Biochemistry, Physics, Optics, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
49Total citation count in OpenAlex
- Citations by year (recent)
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2025: 16, 2024: 25, 2023: 8Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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