Enhancing Differential Diagnosis Related to Oxidative Stress, Nitrous Oxide, and Nutrition by Rapid Plasma Homocysteine Measurement Article Swipe
Guillaume Grzych
,
Farid Zerimech
,
Benjamin Touzé
,
Clarence Descamps
,
Marie-Adélaïde Bout
,
Marie Joncquel-Chevalier Curt
,
Claire Douillard
,
Isabelle Kim
,
Céline Tard
,
Thierry Brousseau
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/jox14040075
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/jox14040075
Background: Historically used as a marker for inherited disorders, the current interest in plasma homocysteine measurement lies in its ability to provide valuable information about the metabolic and nutritional status of patients. Specifically, nitrous oxide (N2O) abuse can lead to functional vitamin B12 deficiency by oxidation and increase oxidative stress, resulting in elevated plasma homocysteine levels, which mimic neurological conditions such as Guillain–Barré syndrome. Rapid identification of hyperhomocysteinemia is crucial for timely intervention and avoiding costly, unnecessary treatments. Objective: This study evaluates the performance of a rapid immunoassay technique (Snibe) compared to mass spectrometry (LC-MS/MS) for measuring plasma homocysteine levels in patients with nitrous oxide abuse and non-inherited caused of elevated homocysteine, aiming to enhance differential diagnosis related to oxidative stress. Methods: 235 patients from Lille University Hospital were included. EDTA blood samples were collected and analyzed using both rapid immunoassay (Snibe) and LC-MS/MS. Neurological assessment was performed using the peripheral neuropathy disability (PND) score. Results: Firstly, significant elevations in plasma homocysteine levels were observed in patients abusing nitrous oxide measured by LC-MS/MS. Secondly, the immunoassay provided rapid results, essential for early clinical decision-making, but tended to underestimate high values compared to LC-MS/MS. A good correlation was found between the methods for low and moderate values. Conclusion: The immunoassay tended to underestimate high-value samples compared to LC-MS/MS, which is a common problem with the competitive methodology. The rapid immunoassay technique is effective for initial screening and early intervention, aiding in the differential diagnosis of conditions related to oxidative stress. Therefore, it is recommended to use the CLIA method for initial screening and confirm with mass spectrometry if there are abnormal samples. Integrating both techniques can enhance diagnostic accuracy and improve patient outcomes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jox14040075
- OA Status
- gold
- Cited By
- 2
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402919128
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402919128Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jox14040075Digital Object Identifier
- Title
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Enhancing Differential Diagnosis Related to Oxidative Stress, Nitrous Oxide, and Nutrition by Rapid Plasma Homocysteine MeasurementWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-27Full publication date if available
- Authors
-
Guillaume Grzych, Farid Zerimech, Benjamin Touzé, Clarence Descamps, Marie-Adélaïde Bout, Marie Joncquel-Chevalier Curt, Claire Douillard, Isabelle Kim, Céline Tard, Thierry BrousseauList of authors in order
- Landing page
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https://doi.org/10.3390/jox14040075Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/jox14040075Direct OA link when available
- Concepts
-
Hyperhomocysteinemia, Homocysteine, Immunoassay, Medicine, Oxidative stress, Nitrous oxide, Internal medicine, Gastroenterology, Anesthesia, Immunology, AntibodyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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