Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys Article Swipe
Alexandra S. Piotrowski-Daspit
,
Laura G. Bracaglia
,
David A. Eaton
,
Owen Richfield
,
Thomas C. Binns
,
Claire Albert
,
Jared Gould
,
Ryland D. Mortlock
,
Marie E. Egan
,
Jordan S. Pober
,
W. Mark Saltzman
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-024-48442-7
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-024-48442-7
The in vivo efficacy of polymeric nanoparticles (NPs) is dependent on their pharmacokinetics, including time in circulation and tissue tropism. Here we explore the structure-function relationships guiding physiological fate of a library of poly(amine-co-ester) (PACE) NPs with different compositions and surface properties. We find that circulation half-life as well as tissue and cell-type tropism is dependent on polymer chemistry, vehicle characteristics, dosing, and strategic co-administration of distribution modifiers, suggesting that physiological fate can be optimized by adjusting these parameters. Our high-throughput quantitative microscopy-based platform to measure the concentration of nanomedicines in the blood combined with detailed biodistribution assessments and pharmacokinetic modeling provides valuable insight into the dynamic in vivo behavior of these polymer NPs. Our results suggest that PACE NPs—and perhaps other NPs—can be designed with tunable properties to achieve desired tissue tropism for the in vivo delivery of nucleic acid therapeutics. These findings can guide the rational design of more effective nucleic acid delivery vehicles for in vivo applications.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-024-48442-7
- https://www.nature.com/articles/s41467-024-48442-7.pdf
- OA Status
- gold
- Cited By
- 15
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4397032481
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4397032481Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41467-024-48442-7Digital Object Identifier
- Title
-
Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoysWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-18Full publication date if available
- Authors
-
Alexandra S. Piotrowski-Daspit, Laura G. Bracaglia, David A. Eaton, Owen Richfield, Thomas C. Binns, Claire Albert, Jared Gould, Ryland D. Mortlock, Marie E. Egan, Jordan S. Pober, W. Mark SaltzmanList of authors in order
- Landing page
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https://doi.org/10.1038/s41467-024-48442-7Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41467-024-48442-7.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41467-024-48442-7.pdfDirect OA link when available
- Concepts
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Biodistribution, In vivo, Biophysics, Nanotechnology, Nucleic acid, Dendrimer, Tropism, Chemistry, Rational design, Intravital microscopy, Materials science, Biochemistry, Biology, Virology, Biotechnology, VirusTop concepts (fields/topics) attached by OpenAlex
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15Total citation count in OpenAlex
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-
2025: 14, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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