Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach Article Swipe
Yisi Liu
,
Meng Wang
,
Yixuan Luo
,
Qianyi Liang
,
Yin Yu
,
Fei Chen
,
Jun Yao
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/gels7040263
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/gels7040263
Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In addition to their multipotency, stem cells possess immunomodulatory effects that can alleviate inflammation and enhance cartilage repair. However, the widely clinical application of stem cell therapy to cartilage repair and osteoarthritis has proven difficult due to challenges in large-scale production, viability maintenance in pathological tissue site and limited therapeutic biological activity. This review aims to provide a perspective from hydrogel-focused approach to address few key challenges in stem cell-based therapy for cartilage repair and highlight recent progress in advanced hydrogels, particularly microgels and dynamic hydrogels systems for improving stem cell survival, retention and regulation of stem cell fate. Finally, progress in hydrogel-assisted gene delivery and genome editing approaches for the development of next generation of stem cell therapy for cartilage repair in osteoarthritis are highlighted.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/gels7040263
- https://www.mdpi.com/2310-2861/7/4/263/pdf?version=1658828742
- OA Status
- gold
- Cited By
- 25
- References
- 78
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200204796
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200204796Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/gels7040263Digital Object Identifier
- Title
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Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused ApproachWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-12-14Full publication date if available
- Authors
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Yisi Liu, Meng Wang, Yixuan Luo, Qianyi Liang, Yin Yu, Fei Chen, Jun YaoList of authors in order
- Landing page
-
https://doi.org/10.3390/gels7040263Publisher landing page
- PDF URL
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https://www.mdpi.com/2310-2861/7/4/263/pdf?version=1658828742Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2310-2861/7/4/263/pdf?version=1658828742Direct OA link when available
- Concepts
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Stem cell, Osteoarthritis, Cartilage, Self-healing hydrogels, Stem-cell therapy, Medicine, Materials science, Biology, Cell biology, Pathology, Anatomy, Polymer chemistry, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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25Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 10, 2023: 5, 2022: 5Per-year citation counts (last 5 years)
- References (count)
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78Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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