Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation Article Swipe
Lei You
,
Junbo Chen
,
Weiyong Liu
,
Qi Xiang
,
Zhen Luo
,
Wenbiao Wang
,
Wei Xu
,
Kailang Wu
,
Zhang Qi
,
Yingle Liu
,
Jianguo Wu
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1080/21505594.2020.1766790
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1080/21505594.2020.1766790
Enterovirus 71 (EV71) infection causes hand, foot, and mouth disease (HFMD), and even fatal neurological complications. However, the mechanisms underlying EV71 neurological pathogeneses are largely unknown. This study reveals a distinct mechanism by which EV71 induces apoptosis and autophagy in neural cells. EV71 non-structure protein 3D (also known as RNA-dependent RNA polymerase, RdRp) interacts with the peroxisomal protein acyl-CoA oxidase 1 (ACOX1), and contributes to ACOX1 downregulation. Further studies demonstrate that EV71 reduces peroxisome numbers. Additionally, knockdown of ACOX1 or peroxin 19 (PEX19) induces apoptosis and autophagy in neural cells including human neuroblastoma (SK-N-SH) cells and human astrocytoma (U251) cells, and EV71 infection induces neural cell death through attenuating ACOX1 production. Moreover, EV71 infection and ACOX1 knockdown facilitate reactive oxygen species (ROS) production and attenuate the cytoprotective protein deglycase (DJ-1)/Nuclear factor erythroid 2-related factor 2 (NRF2)/Heme oxygenase 1 (HO-1) pathway (DJ-1/NRF2/HO-1), which collectively result in ROS accumulation in neural cells. In conclusion, EV71 downregulates ACOX1 protein expression, reduces peroxisome numbers, enhances ROS generation, and attenuates the DJ-1/NRF2/HO-1 pathway, thereby inducing apoptosis and autophagy in neural cells. These findings provide new insights into the mechanism underlying EV71-induced neural pathogenesis, and suggest potential treatments for EV71-associated diseases.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/21505594.2020.1766790
- https://www.tandfonline.com/doi/pdf/10.1080/21505594.2020.1766790?needAccess=true
- OA Status
- gold
- Cited By
- 74
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3027689746
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3027689746Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/21505594.2020.1766790Digital Object Identifier
- Title
-
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-05-20Full publication date if available
- Authors
-
Lei You, Junbo Chen, Weiyong Liu, Qi Xiang, Zhen Luo, Wenbiao Wang, Wei Xu, Kailang Wu, Zhang Qi, Yingle Liu, Jianguo WuList of authors in order
- Landing page
-
https://doi.org/10.1080/21505594.2020.1766790Publisher landing page
- PDF URL
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https://www.tandfonline.com/doi/pdf/10.1080/21505594.2020.1766790?needAccess=trueDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.tandfonline.com/doi/pdf/10.1080/21505594.2020.1766790?needAccess=trueDirect OA link when available
- Concepts
-
Downregulation and upregulation, Autophagy, Cell biology, Apoptosis, Gene knockdown, Neural cell, Biology, RNA interference, Cancer research, Cell, RNA, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
74Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 13, 2024: 15, 2023: 19, 2022: 14, 2021: 10Per-year citation counts (last 5 years)
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63Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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