Entropic barrier of topologically immobilized DNA in hydrogels Article Swipe

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YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1073/pnas.2106380118

Significance Movement of charged macromolecules in crowded aqueous environments is ubiquitous in nature. The omnipresent capacity of macromolecules to adopt differing numbers of conformations in response to local spatiotemporal environments results in their trajectories consisting of conformational entropic barriers. The conformational fluctuations can be so large that even Einstein’s law of diffusion can apparently break down. By directly observing single DNA molecules under such conditions, we show the emergence of a nondiffusive topologically frustrated dynamical state, and measure single-molecule entropic barriers responsible for the resultant extreme metastability. The presented theory–experiment combination offers a general method to measure free energy landscapes required to deliberately navigate single macromolecules through congested aqueous media.

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Self-healing hydrogels DNA Chemistry Biophysics Nanotechnology Polymer science Materials science Polymer chemistry Biology Biochemistry

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Type: article
Language: en
Landing Page: https://doi.org/10.1073/pnas.2106380118
PDF: https://www.pnas.org/content/pnas/118/28/e2106380118.full.pdf
OA Status: bronze
Cited By: 13
References: 52
Related Works: 10
OpenAlex ID: https://openalex.org/W3180317787

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OpenAlex ID: https://openalex.org/W3180317787

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DOI: https://doi.org/10.1073/pnas.2106380118

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Title: Entropic barrier of topologically immobilized DNA in hydrogels

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-07-06

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Authors: Kuo Chen, M. Muthukumar

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Landing page: https://doi.org/10.1073/pnas.2106380118

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PDF URL: https://www.pnas.org/content/pnas/118/28/e2106380118.full.pdf

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OA status: bronze

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Concepts: Self-healing hydrogels, DNA, Chemistry, Biophysics, Nanotechnology, Polymer science, Materials science, Polymer chemistry, Biology, Biochemistry

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Cited by: 13

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Citations by year (recent): 2024: 7, 2023: 3, 2022: 3

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