Enzymes for dermatological use Article Swipe
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/exd.15008
Skin is the ultimate barrier between body and environment and prevents water loss and penetration of pathogens and toxins. Internal and external stressors, such as ultraviolet radiation (UVR), can damage skin integrity and lead to disorders. Therefore, skin health and skin ageing are important concerns and increased research from cosmetic and pharmaceutical sectors aims to improve skin conditions and provide new anti‐ageing treatments. Biomolecules, compared to low molecular weight drugs and cosmetic ingredients, can offer high levels of specificity. Topically applied enzymes have been investigated to treat the adverse effects of sunlight, pollution and other external agents. Enzymes, with a diverse range of targets, present potential for dermatological use such as antioxidant enzymes, proteases and repairing enzymes. In this review, we discuss enzymes for dermatological applications and the challenges associated in this growing field.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/exd.15008
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.15008
- OA Status
- hybrid
- Cited By
- 7
- References
- 252
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390979639
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4390979639Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/exd.15008Digital Object Identifier
- Title
-
Enzymes for dermatological useWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-01Full publication date if available
- Authors
-
Natália Santos Nascimento, Karin Mariana Torres‐Obreque, Camila Areias de Oliveira, Jheniffer Rabelo, André Rolim Baby, Paul F. Long, Antony R. Young, Carlota de Oliveira Rangel‐YaguiList of authors in order
- Landing page
-
https://doi.org/10.1111/exd.15008Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.15008Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.15008Direct OA link when available
- Concepts
-
Proteases, Enzyme, Dermatological diseases, Ultraviolet radiation, Medicine, Dermatology, Chemistry, Biochemistry, RadiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7Per-year citation counts (last 5 years)
- References (count)
-
252Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4390979639 |
|---|---|
| doi | https://doi.org/10.1111/exd.15008 |
| ids.doi | https://doi.org/10.1111/exd.15008 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38284197 |
| ids.openalex | https://openalex.org/W4390979639 |
| fwci | 5.43798921 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000009 |
| mesh[1].descriptor_ui | D014466 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | adverse effects |
| mesh[1].descriptor_name | Ultraviolet Rays |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D012867 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Skin |
| mesh[3].qualifier_ui | Q000628 |
| mesh[3].descriptor_ui | D012871 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | therapy |
| mesh[3].descriptor_name | Skin Diseases |
| mesh[4].qualifier_ui | Q000009 |
| mesh[4].descriptor_ui | D013472 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | adverse effects |
| mesh[4].descriptor_name | Sunlight |
| mesh[5].qualifier_ui | Q000494 |
| mesh[5].descriptor_ui | D003358 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | pharmacology |
| mesh[5].descriptor_name | Cosmetics |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006801 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Humans |
| mesh[7].qualifier_ui | Q000009 |
| mesh[7].descriptor_ui | D014466 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | adverse effects |
| mesh[7].descriptor_name | Ultraviolet Rays |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D012867 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Skin |
| mesh[9].qualifier_ui | Q000628 |
| mesh[9].descriptor_ui | D012871 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | therapy |
| mesh[9].descriptor_name | Skin Diseases |
| mesh[10].qualifier_ui | Q000009 |
| mesh[10].descriptor_ui | D013472 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | adverse effects |
| mesh[10].descriptor_name | Sunlight |
| mesh[11].qualifier_ui | Q000494 |
| mesh[11].descriptor_ui | D003358 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | pharmacology |
| mesh[11].descriptor_name | Cosmetics |
| type | article |
| title | Enzymes for dermatological use |
| biblio.issue | 1 |
| biblio.volume | 33 |
| biblio.last_page | e15008 |
| biblio.first_page | e15008 |
| grants[0].funder | https://openalex.org/F4320320997 |
| grants[0].award_id | 2020/08129‐6 2022/01138‐5 |
| grants[0].funder_display_name | Fundação de Amparo à Pesquisa do Estado de São Paulo |
| grants[1].funder | https://openalex.org/F4320321091 |
| grants[1].award_id | CAPES‐Brazil process number: 001 |
| grants[1].funder_display_name | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| grants[2].funder | https://openalex.org/F4320322025 |
| grants[2].award_id | # 309953/2020‐0 |
| grants[2].funder_display_name | Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| grants[3].funder | https://openalex.org/F4320331146 |
| grants[3].award_id | extranjero/2020 ‐ 72210489 |
| grants[3].funder_display_name | Agencia Nacional de Investigación y Desarrollo |
| topics[0].id | https://openalex.org/T12856 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9904999732971191 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1305 |
| topics[0].subfield.display_name | Biotechnology |
| topics[0].display_name | Transgenic Plants and Applications |
| topics[1].id | https://openalex.org/T11561 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9822999835014343 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Protein Hydrolysis and Bioactive Peptides |
| topics[2].id | https://openalex.org/T10404 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9815999865531921 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Enzyme Catalysis and Immobilization |
| funders[0].id | https://openalex.org/F4320320997 |
| funders[0].ror | https://ror.org/02ddkpn78 |
| funders[0].display_name | Fundação de Amparo à Pesquisa do Estado de São Paulo |
| funders[1].id | https://openalex.org/F4320321091 |
| funders[1].ror | https://ror.org/00x0ma614 |
| funders[1].display_name | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| funders[2].id | https://openalex.org/F4320322025 |
| funders[2].ror | https://ror.org/03swz6y49 |
| funders[2].display_name | Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| funders[3].id | https://openalex.org/F4320331146 |
| funders[3].ror | |
| funders[3].display_name | Agencia Nacional de Investigación y Desarrollo |
| is_xpac | False |
| apc_list.value | 4740 |
| apc_list.currency | USD |
| apc_list.value_usd | 4740 |
| apc_paid.value | 4740 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4740 |
| concepts[0].id | https://openalex.org/C182220744 |
| concepts[0].level | 3 |
| concepts[0].score | 0.6394480466842651 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q7251226 |
| concepts[0].display_name | Proteases |
| concepts[1].id | https://openalex.org/C181199279 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5526806712150574 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[1].display_name | Enzyme |
| concepts[2].id | https://openalex.org/C2909963953 |
| concepts[2].level | 2 |
| concepts[2].score | 0.504069447517395 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q171171 |
| concepts[2].display_name | Dermatological diseases |
| concepts[3].id | https://openalex.org/C2987742019 |
| concepts[3].level | 2 |
| concepts[3].score | 0.49553167819976807 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11391 |
| concepts[3].display_name | Ultraviolet radiation |
| concepts[4].id | https://openalex.org/C71924100 |
| concepts[4].level | 0 |
| concepts[4].score | 0.3836643099784851 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[4].display_name | Medicine |
| concepts[5].id | https://openalex.org/C16005928 |
| concepts[5].level | 1 |
| concepts[5].score | 0.37452325224876404 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q171171 |
| concepts[5].display_name | Dermatology |
| concepts[6].id | https://openalex.org/C185592680 |
| concepts[6].level | 0 |
| concepts[6].score | 0.30450135469436646 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[6].display_name | Chemistry |
| concepts[7].id | https://openalex.org/C55493867 |
| concepts[7].level | 1 |
| concepts[7].score | 0.15189924836158752 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[7].display_name | Biochemistry |
| concepts[8].id | https://openalex.org/C177322064 |
| concepts[8].level | 1 |
| concepts[8].score | 0.0 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q750955 |
| concepts[8].display_name | Radiochemistry |
| keywords[0].id | https://openalex.org/keywords/proteases |
| keywords[0].score | 0.6394480466842651 |
| keywords[0].display_name | Proteases |
| keywords[1].id | https://openalex.org/keywords/enzyme |
| keywords[1].score | 0.5526806712150574 |
| keywords[1].display_name | Enzyme |
| keywords[2].id | https://openalex.org/keywords/dermatological-diseases |
| keywords[2].score | 0.504069447517395 |
| keywords[2].display_name | Dermatological diseases |
| keywords[3].id | https://openalex.org/keywords/ultraviolet-radiation |
| keywords[3].score | 0.49553167819976807 |
| keywords[3].display_name | Ultraviolet radiation |
| keywords[4].id | https://openalex.org/keywords/medicine |
| keywords[4].score | 0.3836643099784851 |
| keywords[4].display_name | Medicine |
| keywords[5].id | https://openalex.org/keywords/dermatology |
| keywords[5].score | 0.37452325224876404 |
| keywords[5].display_name | Dermatology |
| keywords[6].id | https://openalex.org/keywords/chemistry |
| keywords[6].score | 0.30450135469436646 |
| keywords[6].display_name | Chemistry |
| keywords[7].id | https://openalex.org/keywords/biochemistry |
| keywords[7].score | 0.15189924836158752 |
| keywords[7].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1111/exd.15008 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S158010168 |
| locations[0].source.issn | 0906-6705, 1600-0625 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0906-6705 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Experimental Dermatology |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | other-oa |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.15008 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/other-oa |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Experimental Dermatology |
| locations[0].landing_page_url | https://doi.org/10.1111/exd.15008 |
| locations[1].id | pmid:38284197 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Experimental dermatology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38284197 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5010230456 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1196-912X |
| authorships[0].author.display_name | Natália Santos Nascimento |
| authorships[0].countries | BR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I17974374 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[0].institutions[0].id | https://openalex.org/I17974374 |
| authorships[0].institutions[0].ror | https://ror.org/036rp1748 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I17974374 |
| authorships[0].institutions[0].country_code | BR |
| authorships[0].institutions[0].display_name | Universidade de São Paulo |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Natália Santos Nascimento |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[1].author.id | https://openalex.org/A5072017992 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1911-385X |
| authorships[1].author.display_name | Karin Mariana Torres‐Obreque |
| authorships[1].countries | BR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I17974374 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[1].institutions[0].id | https://openalex.org/I17974374 |
| authorships[1].institutions[0].ror | https://ror.org/036rp1748 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I17974374 |
| authorships[1].institutions[0].country_code | BR |
| authorships[1].institutions[0].display_name | Universidade de São Paulo |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Karin Mariana Torres‐Obreque |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[2].author.id | https://openalex.org/A5038837587 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8574-8936 |
| authorships[2].author.display_name | Camila Areias de Oliveira |
| authorships[2].countries | BR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I52325 |
| authorships[2].affiliations[0].raw_affiliation_string | Laboratory of Analytical Validation and Development, Fundação Oswaldo Cruz – FIOCRUZ Rio de Janeiro Brazil |
| authorships[2].institutions[0].id | https://openalex.org/I52325 |
| authorships[2].institutions[0].ror | https://ror.org/04jhswv08 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I52325 |
| authorships[2].institutions[0].country_code | BR |
| authorships[2].institutions[0].display_name | Fundação Oswaldo Cruz |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Camila Areias Oliveira |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Laboratory of Analytical Validation and Development, Fundação Oswaldo Cruz – FIOCRUZ Rio de Janeiro Brazil |
| authorships[3].author.id | https://openalex.org/A5051730521 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Jheniffer Rabelo |
| authorships[3].countries | BR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I17974374 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[3].institutions[0].id | https://openalex.org/I17974374 |
| authorships[3].institutions[0].ror | https://ror.org/036rp1748 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I17974374 |
| authorships[3].institutions[0].country_code | BR |
| authorships[3].institutions[0].display_name | Universidade de São Paulo |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jheniffer Rabelo |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[4].author.id | https://openalex.org/A5005393041 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-9197-3024 |
| authorships[4].author.display_name | André Rolim Baby |
| authorships[4].countries | BR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I17974374 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pharmacy, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[4].institutions[0].id | https://openalex.org/I17974374 |
| authorships[4].institutions[0].ror | https://ror.org/036rp1748 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I17974374 |
| authorships[4].institutions[0].country_code | BR |
| authorships[4].institutions[0].display_name | Universidade de São Paulo |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | André Rolim Baby |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Pharmacy, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[5].author.id | https://openalex.org/A5013443677 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6698-4602 |
| authorships[5].author.display_name | Paul F. Long |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I183935753 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute of Pharmaceutical Science, King's College London London UK |
| authorships[5].institutions[0].id | https://openalex.org/I183935753 |
| authorships[5].institutions[0].ror | https://ror.org/0220mzb33 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I183935753 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | King's College London |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Paul F. Long |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute of Pharmaceutical Science, King's College London London UK |
| authorships[6].author.id | https://openalex.org/A5064410212 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4163-6772 |
| authorships[6].author.display_name | Antony R. Young |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I183935753 |
| authorships[6].affiliations[0].raw_affiliation_string | St John's Institute of Dermatology, King's College London London UK |
| authorships[6].institutions[0].id | https://openalex.org/I183935753 |
| authorships[6].institutions[0].ror | https://ror.org/0220mzb33 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I183935753 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | King's College London |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Antony R. Young |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | St John's Institute of Dermatology, King's College London London UK |
| authorships[7].author.id | https://openalex.org/A5074680251 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4221-9505 |
| authorships[7].author.display_name | Carlota de Oliveira Rangel‐Yagui |
| authorships[7].countries | BR, GB |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I183935753 |
| authorships[7].affiliations[0].raw_affiliation_string | Institute of Pharmaceutical Science, King's College London London UK |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I17974374 |
| authorships[7].affiliations[1].raw_affiliation_string | Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil |
| authorships[7].institutions[0].id | https://openalex.org/I17974374 |
| authorships[7].institutions[0].ror | https://ror.org/036rp1748 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I17974374 |
| authorships[7].institutions[0].country_code | BR |
| authorships[7].institutions[0].display_name | Universidade de São Paulo |
| authorships[7].institutions[1].id | https://openalex.org/I183935753 |
| authorships[7].institutions[1].ror | https://ror.org/0220mzb33 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I124357947, https://openalex.org/I183935753 |
| authorships[7].institutions[1].country_code | GB |
| authorships[7].institutions[1].display_name | King's College London |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Carlota de Oliveira Rangel‐Yagui |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences University of São Paulo (USP) São Paulo Brazil, Institute of Pharmaceutical Science, King's College London London UK |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.15008 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Enzymes for dermatological use |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12856 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9904999732971191 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1305 |
| primary_topic.subfield.display_name | Biotechnology |
| primary_topic.display_name | Transgenic Plants and Applications |
| related_works | https://openalex.org/W2414472555, https://openalex.org/W2357602378, https://openalex.org/W2061945526, https://openalex.org/W3138728990, https://openalex.org/W2094734839, https://openalex.org/W2100844557, https://openalex.org/W2552013322, https://openalex.org/W2286775035, https://openalex.org/W2033546457, https://openalex.org/W3135706158 |
| cited_by_count | 7 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 7 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1111/exd.15008 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S158010168 |
| best_oa_location.source.issn | 0906-6705, 1600-0625 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0906-6705 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Experimental Dermatology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.15008 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Experimental Dermatology |
| best_oa_location.landing_page_url | https://doi.org/10.1111/exd.15008 |
| primary_location.id | doi:10.1111/exd.15008 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S158010168 |
| primary_location.source.issn | 0906-6705, 1600-0625 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0906-6705 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Experimental Dermatology |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | other-oa |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.15008 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/other-oa |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Experimental Dermatology |
| primary_location.landing_page_url | https://doi.org/10.1111/exd.15008 |
| publication_date | 2024-01-01 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4232803139, https://openalex.org/W2497456934, https://openalex.org/W4238956892, https://openalex.org/W2094513195, https://openalex.org/W2049577874, https://openalex.org/W2554871136, https://openalex.org/W3048094105, https://openalex.org/W1977036728, https://openalex.org/W2515782463, https://openalex.org/W2538925390, https://openalex.org/W1995833707, https://openalex.org/W2789608114, https://openalex.org/W90754507, https://openalex.org/W2154011618, https://openalex.org/W2802694151, https://openalex.org/W2761254119, https://openalex.org/W2981815358, https://openalex.org/W2801960533, https://openalex.org/W2047651258, https://openalex.org/W2791564057, https://openalex.org/W3013352992, https://openalex.org/W2067297015, https://openalex.org/W2765183531, https://openalex.org/W1985087138, https://openalex.org/W2042216485, https://openalex.org/W2170058369, https://openalex.org/W3083327458, https://openalex.org/W3195534234, https://openalex.org/W1993257224, https://openalex.org/W1940436875, https://openalex.org/W1970094644, https://openalex.org/W2108947543, https://openalex.org/W2034290776, https://openalex.org/W2020444493, https://openalex.org/W1970928392, https://openalex.org/W2004400264, https://openalex.org/W2042662902, https://openalex.org/W2464368126, https://openalex.org/W2149278013, https://openalex.org/W2989399429, https://openalex.org/W2059616064, https://openalex.org/W2888704494, https://openalex.org/W2002928259, https://openalex.org/W1966172304, https://openalex.org/W2083007831, https://openalex.org/W2002653327, https://openalex.org/W2026114600, https://openalex.org/W2076058833, https://openalex.org/W1547368494, https://openalex.org/W2897082497, https://openalex.org/W2161854858, https://openalex.org/W2097920936, https://openalex.org/W2132577479, https://openalex.org/W2805330870, https://openalex.org/W2513693180, https://openalex.org/W2163453199, https://openalex.org/W2027452552, https://openalex.org/W2941085296, https://openalex.org/W2071527934, https://openalex.org/W1997684915, https://openalex.org/W2086359978, https://openalex.org/W3012249721, https://openalex.org/W4225152554, https://openalex.org/W2998265928, https://openalex.org/W3012212673, https://openalex.org/W2955695284, https://openalex.org/W1659903845, https://openalex.org/W2315236939, https://openalex.org/W1532356406, https://openalex.org/W2015301923, https://openalex.org/W2168518837, https://openalex.org/W4245364642, https://openalex.org/W1585296580, https://openalex.org/W2091558524, https://openalex.org/W1874889389, https://openalex.org/W2038242145, https://openalex.org/W6705484418, https://openalex.org/W2912583419, https://openalex.org/W1999273878, https://openalex.org/W3011237240, https://openalex.org/W1975274192, https://openalex.org/W347989178, https://openalex.org/W2079305156, https://openalex.org/W2019894619, https://openalex.org/W2951856027, https://openalex.org/W3189283190, https://openalex.org/W2019115257, https://openalex.org/W3112353396, https://openalex.org/W1595716614, https://openalex.org/W2746885334, https://openalex.org/W3088908794, https://openalex.org/W2773356475, https://openalex.org/W3047627655, https://openalex.org/W2039528521, https://openalex.org/W1604304380, https://openalex.org/W2972167367, https://openalex.org/W2081748849, https://openalex.org/W2089818796, https://openalex.org/W3142674258, https://openalex.org/W4234785678, https://openalex.org/W2588359075, https://openalex.org/W2068605515, https://openalex.org/W3165074665, https://openalex.org/W3042776291, https://openalex.org/W2144411286, https://openalex.org/W3160932475, https://openalex.org/W2067420478, https://openalex.org/W2091079012, https://openalex.org/W1970519591, https://openalex.org/W2022561948, https://openalex.org/W2009680132, https://openalex.org/W2011667964, https://openalex.org/W2059519613, https://openalex.org/W2062259573, https://openalex.org/W2089626228, https://openalex.org/W2013342221, https://openalex.org/W2083001284, https://openalex.org/W2001368874, https://openalex.org/W2023419047, https://openalex.org/W2105166054, https://openalex.org/W2066780699, https://openalex.org/W2116747538, https://openalex.org/W1965367366, https://openalex.org/W2110735860, https://openalex.org/W2071246416, https://openalex.org/W2509572019, https://openalex.org/W2144075496, https://openalex.org/W1984549556, https://openalex.org/W2045581971, https://openalex.org/W2914568473, https://openalex.org/W2102628698, https://openalex.org/W2067080192, https://openalex.org/W2605973421, https://openalex.org/W2768652310, https://openalex.org/W2031246464, https://openalex.org/W2130171775, https://openalex.org/W2589836012, https://openalex.org/W3112189859, https://openalex.org/W1971952560, https://openalex.org/W2041768492, https://openalex.org/W1978450510, https://openalex.org/W2090701481, https://openalex.org/W1981847958, https://openalex.org/W1973692331, https://openalex.org/W1990023008, https://openalex.org/W4224301757, https://openalex.org/W1959273472, https://openalex.org/W2170400730, https://openalex.org/W2528618064, https://openalex.org/W2288761601, https://openalex.org/W2030947551, https://openalex.org/W2019170339, https://openalex.org/W2031435087, https://openalex.org/W2114003934, https://openalex.org/W2015116686, https://openalex.org/W1985946546, https://openalex.org/W1557183499, https://openalex.org/W2164153391, https://openalex.org/W1965259386, https://openalex.org/W2130876889, https://openalex.org/W2028365995, https://openalex.org/W2074577965, https://openalex.org/W2566640969, https://openalex.org/W3145978093, https://openalex.org/W3114903295, https://openalex.org/W2115367862, https://openalex.org/W2071928197, https://openalex.org/W2036760301, https://openalex.org/W3137946569, https://openalex.org/W2040329411, https://openalex.org/W2086870274, https://openalex.org/W3037057213, https://openalex.org/W1994074626, https://openalex.org/W2070595030, https://openalex.org/W1984664510, https://openalex.org/W2159489841, https://openalex.org/W2022302688, https://openalex.org/W2054746252, https://openalex.org/W2077735637, https://openalex.org/W1994826608, https://openalex.org/W2016885243, https://openalex.org/W1994972521, https://openalex.org/W3119819287, https://openalex.org/W1980363157, https://openalex.org/W2118240325, https://openalex.org/W2080049979, https://openalex.org/W2609899635, https://openalex.org/W2008963074, https://openalex.org/W2753316804, https://openalex.org/W2752294640, https://openalex.org/W2032500729, https://openalex.org/W2616392523, https://openalex.org/W1998174172, https://openalex.org/W2947737686, https://openalex.org/W2800995450, https://openalex.org/W2151264819, https://openalex.org/W2169877348, https://openalex.org/W2011727990, https://openalex.org/W2603839017, https://openalex.org/W2063863990, https://openalex.org/W2970606978, https://openalex.org/W2069609221, https://openalex.org/W1020670623, https://openalex.org/W2803933693, https://openalex.org/W805844262, https://openalex.org/W2913996444, https://openalex.org/W2055660529, https://openalex.org/W2947955105, https://openalex.org/W1607763700, https://openalex.org/W2472977046, https://openalex.org/W1511645940, https://openalex.org/W2049182662, https://openalex.org/W1752734571, https://openalex.org/W2773547529, https://openalex.org/W2794810223, https://openalex.org/W2057927020, https://openalex.org/W2048719481, https://openalex.org/W166238300, https://openalex.org/W6902311007, https://openalex.org/W2594234168, https://openalex.org/W2081159973, https://openalex.org/W2032972307, https://openalex.org/W1984121549, https://openalex.org/W3134655644, https://openalex.org/W3181866254, https://openalex.org/W2898941045, https://openalex.org/W3096857144, https://openalex.org/W2158829775, https://openalex.org/W1580883143, https://openalex.org/W2958430166, https://openalex.org/W1998515717, https://openalex.org/W2016598044, https://openalex.org/W2027999895, https://openalex.org/W2898165653, https://openalex.org/W3035851989, https://openalex.org/W2161438236, https://openalex.org/W3159271656, https://openalex.org/W2071626214, https://openalex.org/W2143118702, https://openalex.org/W1704033785, https://openalex.org/W1965817500, https://openalex.org/W3153262974, https://openalex.org/W2043445890, https://openalex.org/W2985204671, https://openalex.org/W2124110334, https://openalex.org/W2065342114, https://openalex.org/W1554845001, https://openalex.org/W2005403770, https://openalex.org/W2899745119, https://openalex.org/W2160986283, https://openalex.org/W1969853783, https://openalex.org/W2351363357 |
| referenced_works_count | 252 |
| abstract_inverted_index.a | 100 |
| abstract_inverted_index.In | 118 |
| abstract_inverted_index.as | 25, 111 |
| abstract_inverted_index.in | 131 |
| abstract_inverted_index.is | 2 |
| abstract_inverted_index.of | 16, 78, 91, 103 |
| abstract_inverted_index.to | 35, 55, 66, 86 |
| abstract_inverted_index.we | 121 |
| abstract_inverted_index.and | 8, 10, 14, 18, 21, 33, 40, 46, 51, 59, 71, 94, 115, 127 |
| abstract_inverted_index.are | 43 |
| abstract_inverted_index.can | 29, 74 |
| abstract_inverted_index.for | 107, 124 |
| abstract_inverted_index.low | 67 |
| abstract_inverted_index.new | 61 |
| abstract_inverted_index.the | 3, 88, 128 |
| abstract_inverted_index.use | 109 |
| abstract_inverted_index.Skin | 1 |
| abstract_inverted_index.aims | 54 |
| abstract_inverted_index.been | 84 |
| abstract_inverted_index.body | 7 |
| abstract_inverted_index.from | 49 |
| abstract_inverted_index.have | 83 |
| abstract_inverted_index.high | 76 |
| abstract_inverted_index.lead | 34 |
| abstract_inverted_index.loss | 13 |
| abstract_inverted_index.skin | 31, 38, 41, 57 |
| abstract_inverted_index.such | 24, 110 |
| abstract_inverted_index.this | 119, 132 |
| abstract_inverted_index.with | 99 |
| abstract_inverted_index.drugs | 70 |
| abstract_inverted_index.offer | 75 |
| abstract_inverted_index.other | 95 |
| abstract_inverted_index.range | 102 |
| abstract_inverted_index.treat | 87 |
| abstract_inverted_index.water | 12 |
| abstract_inverted_index.(UVR), | 28 |
| abstract_inverted_index.ageing | 42 |
| abstract_inverted_index.damage | 30 |
| abstract_inverted_index.field. | 134 |
| abstract_inverted_index.health | 39 |
| abstract_inverted_index.levels | 77 |
| abstract_inverted_index.weight | 69 |
| abstract_inverted_index.adverse | 89 |
| abstract_inverted_index.agents. | 97 |
| abstract_inverted_index.applied | 81 |
| abstract_inverted_index.barrier | 5 |
| abstract_inverted_index.between | 6 |
| abstract_inverted_index.discuss | 122 |
| abstract_inverted_index.diverse | 101 |
| abstract_inverted_index.effects | 90 |
| abstract_inverted_index.enzymes | 82, 123 |
| abstract_inverted_index.growing | 133 |
| abstract_inverted_index.improve | 56 |
| abstract_inverted_index.present | 105 |
| abstract_inverted_index.provide | 60 |
| abstract_inverted_index.review, | 120 |
| abstract_inverted_index.sectors | 53 |
| abstract_inverted_index.toxins. | 19 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Enzymes, | 98 |
| abstract_inverted_index.Internal | 20 |
| abstract_inverted_index.compared | 65 |
| abstract_inverted_index.concerns | 45 |
| abstract_inverted_index.cosmetic | 50, 72 |
| abstract_inverted_index.enzymes, | 113 |
| abstract_inverted_index.enzymes. | 117 |
| abstract_inverted_index.external | 22, 96 |
| abstract_inverted_index.prevents | 11 |
| abstract_inverted_index.research | 48 |
| abstract_inverted_index.targets, | 104 |
| abstract_inverted_index.ultimate | 4 |
| abstract_inverted_index.Topically | 80 |
| abstract_inverted_index.important | 44 |
| abstract_inverted_index.increased | 47 |
| abstract_inverted_index.integrity | 32 |
| abstract_inverted_index.molecular | 68 |
| abstract_inverted_index.pathogens | 17 |
| abstract_inverted_index.pollution | 93 |
| abstract_inverted_index.potential | 106 |
| abstract_inverted_index.proteases | 114 |
| abstract_inverted_index.radiation | 27 |
| abstract_inverted_index.repairing | 116 |
| abstract_inverted_index.sunlight, | 92 |
| abstract_inverted_index.Therefore, | 37 |
| abstract_inverted_index.associated | 130 |
| abstract_inverted_index.challenges | 129 |
| abstract_inverted_index.conditions | 58 |
| abstract_inverted_index.disorders. | 36 |
| abstract_inverted_index.stressors, | 23 |
| abstract_inverted_index.antioxidant | 112 |
| abstract_inverted_index.environment | 9 |
| abstract_inverted_index.penetration | 15 |
| abstract_inverted_index.treatments. | 63 |
| abstract_inverted_index.ultraviolet | 26 |
| abstract_inverted_index.applications | 126 |
| abstract_inverted_index.ingredients, | 73 |
| abstract_inverted_index.investigated | 85 |
| abstract_inverted_index.specificity. | 79 |
| abstract_inverted_index.Biomolecules, | 64 |
| abstract_inverted_index.anti‐ageing | 62 |
| abstract_inverted_index.dermatological | 108, 125 |
| abstract_inverted_index.pharmaceutical | 52 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.800000011920929 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.91396621 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |