Eosinophil and airway nerve interactions in asthma Article Swipe
Matthew G. Drake
,
Katie M. Lebold
,
Quinn R. Roth‐Carter
,
Alexandra Pincus
,
Emily Blum
,
Becky J. Proskocil
,
David B. Jacoby
,
A.D. Fryer
,
Zhenying Nie
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1002/jlb.3mr1117-426r
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1002/jlb.3mr1117-426r
Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons’ activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils’ effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma. Eosinophils are recruited to airway nerves and cause excessive bronchoconstriction in asthma by altering nerve function.
Related Topics
Concepts
Bronchoconstriction
Sensory nerve
Eosinophil
Muscarinic acetylcholine receptor
Sensory system
Parasympathetic nervous system
Airway
Vagus nerve
Reflex
Medicine
Neuroscience
Asthma
Immunology
Biology
Anesthesia
Receptor
Internal medicine
Autonomic nervous system
Stimulation
Blood pressure
Heart rate
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/jlb.3mr1117-426r
- OA Status
- green
- Cited By
- 94
- References
- 108
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2797517655
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2797517655Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jlb.3mr1117-426rDigital Object Identifier
- Title
-
Eosinophil and airway nerve interactions in asthmaWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-04-06Full publication date if available
- Authors
-
Matthew G. Drake, Katie M. Lebold, Quinn R. Roth‐Carter, Alexandra Pincus, Emily Blum, Becky J. Proskocil, David B. Jacoby, A.D. Fryer, Zhenying NieList of authors in order
- Landing page
-
https://doi.org/10.1002/jlb.3mr1117-426rPublisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/6541210Direct OA link when available
- Concepts
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Bronchoconstriction, Sensory nerve, Eosinophil, Muscarinic acetylcholine receptor, Sensory system, Parasympathetic nervous system, Airway, Vagus nerve, Reflex, Medicine, Neuroscience, Asthma, Immunology, Biology, Anesthesia, Receptor, Internal medicine, Autonomic nervous system, Stimulation, Blood pressure, Heart rateTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
94Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 12, 2023: 19, 2022: 13, 2021: 20Per-year citation counts (last 5 years)
- References (count)
-
108Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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