Epidemiologic Method Review at Scale: Assessing Charlson Comorbidity Versioning Using a Large Language Model

Exploring foci of: bioRxiv (Cold Spring Harbor Laboratory) Epidemiologic Method Review at Scale: Assessing Charlson Comorbidity Versioning Using a Large Language Model September 2025 • J. Fuchs, Craig R. Johnson, Nathan R. Foster, Peter Leese Abstract The Charlson Comorbidity Index (CCI) is widely used in epidemiologic studies. However, many versions of the CCI have been developed since the original method was published in 1987, and it is unclear which version is used most frequently and how version utilization in research has changed over time. We present an approach using a large language model to extract data from articles by detecting which specific CCI version is employed. We analyzed 31,767 articles published since 2012 to evaluate the landscape … Open Article Page

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