Epidemiology of brain metastases and leptomeningeal disease Article Swipe
Nayan Lamba
,
Patrick Y. Wen
,
Ayal A. Aizer
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noab101
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noab101
Brain metastases affect a significant percentage of patients with advanced extracranial malignancies. Yet, the incidence of brain metastases remains poorly described, largely due to limitations of population-based registries, a lack of mandated reporting of brain metastases to federal agencies, and historical difficulties with delineation of metastatic involvement of individual organs using claims data. However, in 2016, the Surveillance Epidemiology and End Results (SEER) program released data relating to the presence vs absence of brain metastases at diagnosis of oncologic disease. In 2020, studies demonstrating the viability of utilizing claims data for identifying the presence of brain metastases, date of diagnosis of intracranial involvement, and initial treatment approach for brain metastases were published, facilitating epidemiologic investigations of brain metastases on a population-based level. Accordingly, in this review, we discuss the incidence, clinical presentation, prognosis, and management patterns of patients with brain metastases. Leptomeningeal disease is also discussed. Considerations regarding individual tumor types that commonly metastasize to the brain are provided.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1093/neuonc/noab101
- https://academic.oup.com/neuro-oncology/article-pdf/23/9/1447/40352585/noab101.pdf
- OA Status
- bronze
- Cited By
- 321
- References
- 104
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3159719186
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3159719186Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/neuonc/noab101Digital Object Identifier
- Title
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Epidemiology of brain metastases and leptomeningeal diseaseWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-22Full publication date if available
- Authors
-
Nayan Lamba, Patrick Y. Wen, Ayal A. AizerList of authors in order
- Landing page
-
https://doi.org/10.1093/neuonc/noab101Publisher landing page
- PDF URL
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https://academic.oup.com/neuro-oncology/article-pdf/23/9/1447/40352585/noab101.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
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https://academic.oup.com/neuro-oncology/article-pdf/23/9/1447/40352585/noab101.pdfDirect OA link when available
- Concepts
-
Medicine, Epidemiology, Incidence (geometry), Disease, Brain metastasis, Population, Brain tumor, Presentation (obstetrics), Brain disease, Oncology, Pathology, Internal medicine, Radiology, Cancer, Metastasis, Optics, Physics, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
321Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 87, 2024: 100, 2023: 74, 2022: 55, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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104Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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