Epigenetic Activation of Circadian Clock Genes Elicits Inflammation in Experimental Murine Dry Eye Article Swipe
Ruifen Wei
,
Qianqian Chen
,
Qinxiang Zheng
,
Peter S. Reinach
,
Xiying Tan
,
Chengjie Pan
,
Wei Xu
,
Louis Tong
,
Wei Chen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.22796070
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.22796070
To explore whether circadian clock genes contribute to elicit inflammation in experimental dry eye (EDE). RNA sequencing analyzed mRNA expression patterns in EDE model. RT-qPCR and/or Western blot determined the expression of inflammatory factors and circadian genes during EDE. MethylTarget™ assays determined the promoter methylation levels of Per genes in vivo. Per2 or Per3 knockdown assessed their effects on inflammatory factors in vitro. We utilized an intelligently controlled environmental system (ICES) to establish a mouse EDE model. The significant upregulated genes were enriched for circadian rhythms. Therein lied oscillatory and time-dependent upregulation of PER2 and PER3, as well as their promoter hypomethylation during EDE. Silencing PER2 or PER3 significantly decreased inflammatory factor expression and also reversed such increased inflammatory response in azacitidine (AZA) treatment in vitro model. Our findings suggest that DNA methylation mediated the upregulation of PER2 and PER3, leading to inflammatory response in EDE.
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- Title
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Epigenetic Activation of Circadian Clock Genes Elicits Inflammation in Experimental Murine Dry EyeWork title
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datasetOpenAlex work type
- Language
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2023Year of publication
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2023-01-01Full publication date if available
- Authors
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Ruifen Wei, Qianqian Chen, Qinxiang Zheng, Peter S. Reinach, Xiying Tan, Chengjie Pan, Wei Xu, Louis Tong, Wei ChenList of authors in order
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https://doi.org/10.6084/m9.figshare.22796070Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.6084/m9.figshare.22796070Direct OA link when available
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Circadian rhythm, Circadian clock, Inflammation, Epigenetics, CLOCK, Gene, Biology, Cell biology, Neuroscience, Genetics, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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